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Erschienen in: Wiener klinische Wochenschrift 7-8/2015

01.04.2015 | original article

Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis?

verfasst von: MD Emrah Posul, MD Bulent Yilmaz, MD Gulali Aktas, MD Assoc. Prof. Mevlut Kurt

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2015

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Summary

Background

Inflammatory markers have been studied in ulcerative colitis (UC) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some malignancies and coronary artery disease. Blood N/L ratio is a simple sign of clinical inflammation. In this study, we examined N/L ratio in recurrent patients suffering from UC.

Methods

The aim of the present study was to analyze N/L ratios in serum samples of UC patients in remission and active phases. Patients’ age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for patients. C-reactive protein, erythrocyte sedimentation rate, and complete blood count were determined for patients.

Results

Forty-nine UC patients were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive UC patients (p < 0.05). The cut-off value for N/L ratio for the detection of active UC patients was calculated as ≥ 2.3 using receiver operating characteristic analysis [sensitivity: 61.2 %, specificity: 66.7 %, AUC: 0.650 (0.540–0.760), p = 0.01].

Conclusions

Present study shows that in patients with UC, the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in UC.
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Metadaten
Titel
Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis?
verfasst von
MD Emrah Posul
MD Bulent Yilmaz
MD Gulali Aktas
MD Assoc. Prof. Mevlut Kurt
Publikationsdatum
01.04.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0683-5

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