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Erschienen in: Wiener klinische Wochenschrift 7-8/2015

01.04.2015 | original article

N-acetylcysteine in patients with COPD exacerbations associated with increased sputum

verfasst von: Zeynep Ayfer Aytemur, Aysegul Baysak, Ozer Ozdemir, Timur Köse, Prof. Abdullah Sayiner

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2015

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Summary

Background

N-acetylcysteine (NAC) has been shown not to alter the clinical outcome in chronic obstructive pulmonary disease (COPD) exacerbations. However, NAC may improve symptoms through its mucolytic effect in the subgroup of patients with increased sputum production. The aims of this study were to determine whether NAC improves symptoms and pulmonary function in patients with COPD exacerbation and increased sputum production.

Methods

This was a placebo-controlled study, where patients with severe COPD and increased sputum production, who were hospitalized for an exacerbation, were included. They were randomized to receive either NAC 200 mg tid or placebo in addition to the usual treatment.

Results

Forty-two patients were included and were equally distributed to NAC and placebo groups. The symptoms, namely, ease of sputum production and dyspnea at rest and on exertion significantly improved in both groups; but there was no difference in improvement between NAC and placebo groups (p = 0.96, 0.62, 0.31, respectively). Similarly, forced expiratory volume-one second (FEV1) and PaO2 levels improved significantly in NAC (964 ± 599–1239 ± 543 ml, p < 0.001, and 57.5 ± 14.5–70.5 ± 16.0 mmHg, p < 0.001, respectively) and placebo groups (981 ± 514–1180 ± 535 ml, p < 0.001 and 57.9 ± 14.3–68.7 ± 19.0 mmHg, p < 0.001, respectively), without any difference between the two groups (p = 0.52 and 0.57). There was no difference in the number of exacerbations during the 6-month follow-up period.

Conclusion

NAC does not have any beneficial effect on clinical outcomes in patients with severe COPD exacerbation associated with increased and/or viscous mucus production.
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Metadaten
Titel
N-acetylcysteine in patients with COPD exacerbations associated with increased sputum
verfasst von
Zeynep Ayfer Aytemur
Aysegul Baysak
Ozer Ozdemir
Timur Köse
Prof. Abdullah Sayiner
Publikationsdatum
01.04.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0692-4

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