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01.08.2013 | original article | Ausgabe 15-16/2013

Wiener klinische Wochenschrift 15-16/2013

A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 15-16/2013
Autoren:
MD Bahadir Ceylan, Bilgül Mete, Muzaffer Fincanci, Turan Aslan, Yasemin Akkoyunlu, Nail Ozguneş, Onur Colak, Alper Gunduz, Ebubekir Senates, Resat Ozaras, Ayşe İnci, Fehmi Tabak

Summary

Background

We aimed to investigate whether mean platelet volume (MPV) and platelet distribution width (PDW) are variables determining the severity of liver fibrosis in patients with chronic HBV infection.

Methods

Patients were divided into two groups with fibrosis scores of 0–2 and 3–6 (according to Ishac scoring system). Whether MPV and PDW were independent variables determining the severity of liver fibrosis score or not was investigated by comparing these groups.

Results

Of the 111 cases, 74 (66.7 %) were male (mean age 37.7 ± 11.6 years). Twenty-two of the cases (19.8 %) were HBeAg-positive. Fibrosis scores of 42 cases (37.8 %) were ≥ 3 and the remaining 69 cases had fibrosis scores < 3 (62.2 %). Independent variables determining the severity of fibrosis score were low levels of albumin and mean platelet volume, and high levels of prothrombin time and PDW (Odds ratio (95 % confidence interval) and p values were 0.105 (0.018–0.605) and 0.012 for albumin, 0.402 (0.234–0.692) and 0.001 for mean platelet volume, 1.529 (1.183–1.975) and 0.001 for PDW, and 0.924 (0.875–0.976) and 0.005 for prothrombin time, respectively). The sensitivity, specificity, positive predictive value and negative predictive value of regression model that is established using above mentioned parameters were 88.1, 75.3, 68.5, and 91.7 %, respectively (AUC = 0.886, p = 0.0001).

Conclusions

MPV and PDW are independent variables determining the severity of liver fibrosis, and the regression model that is established using these parameters along with other markers, may give more information about the severity of liver fibrosis.

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