nach oben

Erschienen in:

01.08.2013 | original article

Evaluation of arterial stiffness and hemodynamics by oscillometric method in patients with systemic sclerosis

verfasst von: Murat Sunbul, MD, Assoc. Prof. Kursat Tigen, MD, Gulsen Ozen, MD, Erdal Durmus, MD, Tarik Kivrak, MD, Altug Cincin, MD, Alper Kepez, MD, Halil Atas, MD, Prof. Haner Direskeneli, MD, Prof. Yelda Basaran, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2013

Einloggen, um Zugang zu erhalten

Summary

Objectives

Arterial stiffness and its hemodynamic consequences are associated with adverse cardiovascular events. Pulse wave velocity (PWV) and augmentation index (AIx) are noninvasive markers of arterial stiffness. Systemic sclerosis (SSc) is a systemic, autoimmune disease affecting mainly the small vessels. The aim of this study was to evaluate the arterial stiffness parameters and hemodynamics by oscillometric method in patients with SSc.

Methods

Thirty-five consecutive patients with diagnosed SSc and 35 age- and sex-matched healthy controls were included in the study. Measurements of arterial stiffness were carried out by using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery.

Results

While hemodynamic parameters were not statistically significant between SSc and control groups, heart rate was significantly higher in SSc group (84 ± 12 and 72 ± 7 bpm, p = 0.001). SSc patients had significantly higher AIx and PWV values compared with controls (27.9 ± 12.4 versus 21.0 ± 11.4 %, p = 0.019 and 6.56 ± 1.5 versus 5.04 ± 0.17 m/s, p < 0.001, respectively). PWV was significantly associated with SSc when adjusted by heart rate (p = 0.001, Odds ratio (OR): 17.304, 95 % confidence interval (CI): 3.225–92.832).

Conclusions

PWV and AIx were significantly higher in patients with SSc. Measurement of arterial stiffness parameters using oscillometric method was reliable, reproducible and easy in patients with SSc.

Vorheriger Artikel A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection

Nächster Artikel Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section

Greenland P, Alpert JS, Beller GA, et al. “2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American college of cardiology foundation/American heart association task force on practice guidelines”. J Am Coll Cardiol. 2010;56:e50–103.

Mattace-Raso F, Hofman A, Verwoert GC, et al. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: “establishing normal and reference values”. Eur Heart J. 2010;31:2338–50.CrossRef

Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham heart study. Circulation. 2010;121:505–11.PubMedCrossRef

Franklin SS. Beyond blood pressure: arterial stiffness as a new biomarker of cardiovascular disease. J Am Soc Hypertens. 2008;2:140–51.

Payne RA, Wilkinson IB, Webb DJ. Arterial stiffness and hypertension: emerging concepts. Hypertension. 2010;55:9–14.PubMedCrossRef

Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol. 2003;23:554–66.PubMedCrossRef

Liu CS, Li CI, Shih CM, et al. Arterial stiffness measured as pulse wave velocity is highly correlated with coronary atherosclerosis in asymptomatic patients. J Atheroscler Thromb. 2011;18:652–8.PubMedCrossRef

Sherer Y, Shoenfeld Y. Mechanisms of disease: atherosclerosis in autoimmune diseases. Nat Clin Pract Rheumatol. 2006;2:1–8.CrossRef

Shoenfeld Y, Gerli R, Doria A, et al. Accelerated atherosclerosis in autoimmune rheumatic diseases. Circulation. 2005;112:3337–47.PubMedCrossRef

10.

Veale DJ, Collidge TA, Belch JJ. Increased prevalence of symptomatic macrovascular disease in systemic sclerosis. Ann Rheum Dis. 1995;54:853–5.PubMedCrossRef

11.

Gosse P, Taillard J, Constans J, and the ERAMS Study Investigators. Evolution of ambulatory measurement of blood pressure and parameters of arterial stiffness over a 1-year period in patients with systemic sclerosis: ERAMS study. J Hum Hypertens. 2002;16:627–30.PubMedCrossRef

12.

Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 1980;23:581–90.

13.

Van Bortel LM, Duprez D, Starmans-Kool MJ, et al. Clinical applications of arterial stiffness, Task Force III: recommendations for user procedures. Am J Hypertens. 2002;15:445–52.PubMedCrossRef

14.

Zeng Y, Li M, Xu D, et al. Macrovascular involvement in systemic sclerosis: evidence of correlation with disease activity. Clin Exp Rheumatol. 2012;30:76–80.

15.

Celik A, Ozçetin M, Yerli Y, Damar IH, Kadι H, Koç F, Ceyhan K. Increased aortic pulse wave velocity in obese children. Turk Kardiyol Dern Ars. 2011;39:557–62.PubMedCrossRef

16.

Yeboah J, Crouse JR, Hsu FC, et al. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the cardiovascular health study. Circulation. 2007;115:2390–7.PubMedCrossRef

17.

Rollando D, Bezante GP, Sulli A, et al. Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment. J Rheumatol. 2010;37:1168–73.PubMedCrossRef

18.

Piccione MC, Bagnato G, Zito C, et al. Early identification of vascular damage in patients with systemic sclerosis. Angiology. 2011;62:338–43.PubMedCrossRef

19.

Timár O, Soltész P, Szamosi S, et al. Increased arterial stiffness as the marker of vascular involvement in systemic sclerosis. J Rheumatol. 2008;35:1329–33.PubMed

20.

Cypiene A, Laucevicius A, Venalis A, et al. The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function. Clin Rheumatol. 2008;27:1517–22.PubMedCrossRef

21.

Tomiyama H, Yamashina A. Non-invasive vascular function tests: their pathophysiological background and clinical application. Circ J. 2010;74(1):24–33.PubMedCrossRef

22.

Andersen GN, Mincheva-Nilsson L, Kazzam E, et al. Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production. Arthritis Rheum. 2002;46(5):1324–32.PubMedCrossRef

23.

Pannier B, Guerin AP, Marchais SJ, et al. Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients. Hypertension. 2005;45:592–6.PubMedCrossRef

24.

Karamanoglu M, Gallagher DE, Avolio AP, et al. Pressure wave propagation in a multibranched model of the human upper limb. Am J Physiol. 1995;269:H1363–9

25.

Pannier B, Avolio AP, Hoeks A, et al. Methods and devices for measuring arterial compliance in humans. Am J Hypertens. 2002;15:743–53.PubMedCrossRef

26.

Baulmann J, Schillings U, Rickert S, et al. New oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods. J Hypertens. 2008;26:523–8.PubMedCrossRef

27.

O Hartaigh B, Bosch JA, Carroll D, et al. Evidence of a synergistic association between heart rate, inflammation, and cardiovascular mortality in patient undergoing coronary angiography. Eur Heart J. 2013;34(12):932–41.

28.

Di Franco M, Paradiso M, Riccieri V, et al. Autonomic dysfunction and microvascular damage in systemic sclerosis. Clin Rheumatol. 2007;26:1278–83.PubMedCrossRef

29.

Villa-Forte A, Mandell BF. Cardiovascular disorders and rheumatic disease. Rev Esp Cardiol. 2011;64:809–17.PubMedCrossRef

30.

Meune C, Vignaux O, Kahan A, Allanore Y. Heart involvement in systemic sclerosis: evolving concept and diagnostic methodologies. Arch Cardiovasc Dis. 2010;103(1):46–52.PubMedCrossRef

31.

Au K, Singh MK, Bodukam V, et al. Atherosclerosis in systemic sclerosis: a systematic review and meta-analysis. Arthritis Rheum. 2011;63(7):2078–90.PubMedCrossRef

Titel: Evaluation of arterial stiffness and hemodynamics by oscillometric method in patients with systemic sclerosis
verfasst von: Murat Sunbul, MD
Assoc. Prof. Kursat Tigen, MD
Gulsen Ozen, MD
Erdal Durmus, MD
Tarik Kivrak, MD
Altug Cincin, MD
Alper Kepez, MD
Halil Atas, MD
Prof. Haner Direskeneli, MD
Prof. Yelda Basaran, MD
Publikationsdatum: 01.08.2013
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 15-16/2013
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-013-0396-1

Springer Medizin Österreich

Summary

Objectives

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 15-16/2013

A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection

A rare cause of acute coronary syndrome: electrical shock

Nachruf Prof. Dr. Walter H. Hörl 11.7.1945 – 25.6.2013

Preisverleihung

Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section

Unmeasured anions are associated with short-term mortality in patients with hypoxic hepatitis