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01.08.2013 | original article | Ausgabe 15-16/2013

Wiener klinische Wochenschrift 15-16/2013

Evaluation of arterial stiffness and hemodynamics by oscillometric method in patients with systemic sclerosis

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 15-16/2013
Autoren:
MD Murat Sunbul, MD Assoc. Prof. Kursat Tigen, MD Gulsen Ozen, MD Erdal Durmus, MD Tarik Kivrak, MD Altug Cincin, MD Alper Kepez, MD Halil Atas, MD Prof. Haner Direskeneli, MD Prof. Yelda Basaran

Summary

Objectives

Arterial stiffness and its hemodynamic consequences are associated with adverse cardiovascular events. Pulse wave velocity (PWV) and augmentation index (AIx) are noninvasive markers of arterial stiffness. Systemic sclerosis (SSc) is a systemic, autoimmune disease affecting mainly the small vessels. The aim of this study was to evaluate the arterial stiffness parameters and hemodynamics by oscillometric method in patients with SSc.

Methods

Thirty-five consecutive patients with diagnosed SSc and 35 age- and sex-matched healthy controls were included in the study. Measurements of arterial stiffness were carried out by using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery.

Results

While hemodynamic parameters were not statistically significant between SSc and control groups, heart rate was significantly higher in SSc group (84 ± 12 and 72 ± 7 bpm, p = 0.001). SSc patients had significantly higher AIx and PWV values compared with controls (27.9 ± 12.4 versus 21.0 ± 11.4 %, p = 0.019 and 6.56 ± 1.5 versus 5.04 ± 0.17 m/s, p < 0.001, respectively). PWV was significantly associated with SSc when adjusted by heart rate (p = 0.001, Odds ratio (OR): 17.304, 95 % confidence interval (CI): 3.225–92.832).

Conclusions

PWV and AIx were significantly higher in patients with SSc. Measurement of arterial stiffness parameters using oscillometric method was reliable, reproducible and easy in patients with SSc.

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