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Erschienen in: Wiener klinische Wochenschrift 7-8/2016

01.04.2016 | short report

Use of nonsteroidal anti-inflammatory drugs and renal failure in nursing home residents—results of the study “Inappropriate Medication in Patients with Renal Insufficiency in Nursing Homes”

verfasst von: Dr. rer. nat. Michael Dörks, Prof. Dr. med. Stefan Herget-Rosenthal, MPH PD. Dr. med. Guido Schmiemann, MPH Prof. Dr. P.H. Falk Hoffmann

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2016

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Summary

Background

Use of potentially inappropriate medications may result in increased morbidity, mortality and resource utilisation. Due to polypharmacy and age-related decline in renal function the elderly population is at particular risk. Therefore, the Beers Criteria include use of nonsteroidal anti-inflammatory drugs in chronic renal failure stage 4 and 5 as these drugs may worsen renal function. According to the summary of product characteristics, the nonsteroidal anti-inflammatory drugs ibuprofen and diclofenac are contraindicated in these patients.
Objective was to assess the extent of nonsteroidal anti-inflammatory drug use in nursing homes with a focus on residents with severe renal failure.

Methods

Multi-centre cross-sectional study in 21 German nursing homes. The study population comprised residents for whom at least one serum creatinine value and information about sex were available, so that creatinine clearance rate could be estimated.

Results

In all, 685 of 852 residents were included as they fulfilled the abovementioned criteria. Renal failure was severe (estimated creatinine clearance rate < 30 ml/min) in 106 residents (15.5 %). Approximately one-fifth was treated with at least one nonsteroidal anti-inflammatory drug in both the total study population (20.3 %) and that with severe renal failure (20.8 %). With one exception, all residents prescribed nonsteroidal anti-inflammatory drugs with severe renal failure were treated with at least one nonsteroidal anti-inflammatory drug that was contraindicated due to the underlying renal function.

Conclusions

Notwithstanding their classification as potentially inappropriate medications and underlying contraindications, use of nonsteroidal anti-inflammatory drugs is common among nursing home residents with severe renal failure.
Literatur
1.
Zurück zum Zitat Colloca G, Tosato M, Vetrano DL, et al. Inappropriate drugs in elderly patients with severe cognitive impairment: results from the shelter study. PLoS One. 2012;7: e46669. CrossRefPubMedPubMedCentral Colloca G, Tosato M, Vetrano DL, et al. Inappropriate drugs in elderly patients with severe cognitive impairment: results from the shelter study. PLoS One. 2012;7: e46669. CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Mann E, Haastert B, Böhmdorfer B, et al. Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study. Wien Klin Wochenschr. 2013;125:180–8. CrossRefPubMed Mann E, Haastert B, Böhmdorfer B, et al. Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study. Wien Klin Wochenschr. 2013;125:180–8. CrossRefPubMed
3.
Zurück zum Zitat Stafford AC, Alswayan MS, Tenni PC. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther. 2011;36:33–44. CrossRefPubMed Stafford AC, Alswayan MS, Tenni PC. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther. 2011;36:33–44. CrossRefPubMed
4.
Zurück zum Zitat Hefner G, Stieffenhofer V, Gabriel S, et al. Side effects related to potentially inappropriate medications in elderly psychiatric patients under everyday pharmacotherapy. Eur J Clin Pharmacol. 2015;71:165–72. CrossRefPubMed Hefner G, Stieffenhofer V, Gabriel S, et al. Side effects related to potentially inappropriate medications in elderly psychiatric patients under everyday pharmacotherapy. Eur J Clin Pharmacol. 2015;71:165–72. CrossRefPubMed
5.
Zurück zum Zitat Jones SA, Bhandari S. The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease. Postgrad Med J. 2013;89:247–50. CrossRefPubMed Jones SA, Bhandari S. The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease. Postgrad Med J. 2013;89:247–50. CrossRefPubMed
6.
Zurück zum Zitat Campanelli CM; The American Geriatrics Society 2012 Beers Criteria Update Expert Panel. Updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60:616–31. CrossRefPubMedCentral Campanelli CM; The American Geriatrics Society 2012 Beers Criteria Update Expert Panel. Updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60:616–31. CrossRefPubMedCentral
7.
Zurück zum Zitat Modig S, Lannering C, Ostgren CJ, et al. The assessment of renal function in relation to the use of drugs in elderly in nursing homes; a cohort study. BMC Geriatr. 2011;11:1. CrossRefPubMedPubMedCentral Modig S, Lannering C, Ostgren CJ, et al. The assessment of renal function in relation to the use of drugs in elderly in nursing homes; a cohort study. BMC Geriatr. 2011;11:1. CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Joseph J, Koka M, Aronow WS. Prevalence of moderate and severe renal insufficiency in older persons with hypertension, diabetes mellitus, coronary artery disease, peripheral arterial disease, ischemic stroke, or congestive heart failure in an academic nursing home. J Am Med Dir Assoc. 2008;9:257–9. CrossRefPubMed Joseph J, Koka M, Aronow WS. Prevalence of moderate and severe renal insufficiency in older persons with hypertension, diabetes mellitus, coronary artery disease, peripheral arterial disease, ischemic stroke, or congestive heart failure in an academic nursing home. J Am Med Dir Assoc. 2008;9:257–9. CrossRefPubMed
9.
Zurück zum Zitat Garg AX, Papaioannou A, Ferko N, et al. Estimating the prevalence of renal insufficiency in seniors requiring long-term care. Kidney Int. 2004;65:649–53. CrossRefPubMed Garg AX, Papaioannou A, Ferko N, et al. Estimating the prevalence of renal insufficiency in seniors requiring long-term care. Kidney Int. 2004;65:649–53. CrossRefPubMed
10.
Zurück zum Zitat Ingrasciotta Y, Sultana J, Giorgianni F, et al. The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy. PLoS One 2014;9:e89072. CrossRefPubMedPubMedCentral Ingrasciotta Y, Sultana J, Giorgianni F, et al. The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy. PLoS One 2014;9:e89072. CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Ingrasciotta Y, Sultana J, Giorgianni F, et al. Association of individual non-steroidal anti-inflammatory drugs and chronic kidney disease: a population-based case control study. PLoS One. 2015;10:e0122899. CrossRefPubMedPubMedCentral Ingrasciotta Y, Sultana J, Giorgianni F, et al. Association of individual non-steroidal anti-inflammatory drugs and chronic kidney disease: a population-based case control study. PLoS One. 2015;10:e0122899. CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Hanlon JT, Wang X, Handler SM, et al. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients. J Am Med Dir Assoc. 2011;12:377–83. CrossRefPubMedPubMedCentral Hanlon JT, Wang X, Handler SM, et al. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients. J Am Med Dir Assoc. 2011;12:377–83. CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Papaioannou A, Clarke JA, Campbell G, et al. Assessment of adherence to renal dosing guidelines in long-term care facilities. J Am Geriatr Soc. 2000;48:1470–3. CrossRefPubMed Papaioannou A, Clarke JA, Campbell G, et al. Assessment of adherence to renal dosing guidelines in long-term care facilities. J Am Geriatr Soc. 2000;48:1470–3. CrossRefPubMed
14.
Zurück zum Zitat Rahimi AR, Kennedy K, Thomason M, et al. Improper renal dosing in long-term care facilities. South Med J. 2008;101:802–5. CrossRefPubMed Rahimi AR, Kennedy K, Thomason M, et al. Improper renal dosing in long-term care facilities. South Med J. 2008;101:802–5. CrossRefPubMed
15.
Zurück zum Zitat Schneider V, Lévesque LE, Zhang B, et al. Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: a population-based, nested case-control analysis. Am J Epidemiol. 2006;164:881–9. CrossRefPubMed Schneider V, Lévesque LE, Zhang B, et al. Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: a population-based, nested case-control analysis. Am J Epidemiol. 2006;164:881–9. CrossRefPubMed
16.
Zurück zum Zitat Schubert I, Küpper-Nybelen J, Ihle P, et al. Prescribing potentially inappropriate medication (PIM) in Germany’s elderly as indicated by the PRISCUS list. An analysis based on regional claims data. Pharmacoepidemiol Drug Saf. 2013;22:719–27. CrossRefPubMed Schubert I, Küpper-Nybelen J, Ihle P, et al. Prescribing potentially inappropriate medication (PIM) in Germany’s elderly as indicated by the PRISCUS list. An analysis based on regional claims data. Pharmacoepidemiol Drug Saf. 2013;22:719–27. CrossRefPubMed
17.
Zurück zum Zitat Barnett K, McCowan C, Evans JMM, et al. Prevalence and outcomes of use of potentially inappropriate medicines in older people: cohort study stratified by residence in nursing home or in the community. BMJ Qual Saf. 2011;20:275–81. CrossRefPubMed Barnett K, McCowan C, Evans JMM, et al. Prevalence and outcomes of use of potentially inappropriate medicines in older people: cohort study stratified by residence in nursing home or in the community. BMJ Qual Saf. 2011;20:275–81. CrossRefPubMed
Metadaten
Titel
Use of nonsteroidal anti-inflammatory drugs and renal failure in nursing home residents—results of the study “Inappropriate Medication in Patients with Renal Insufficiency in Nursing Homes”
verfasst von
Dr. rer. nat. Michael Dörks
Prof. Dr. med. Stefan Herget-Rosenthal
MPH PD. Dr. med. Guido Schmiemann
MPH Prof. Dr. P.H. Falk Hoffmann
Publikationsdatum
01.04.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0919-z

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