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01.04.2014 | case report | Sonderheft 1/2014

Wiener klinische Wochenschrift 1/2014

Toxocarosis and putative DRESS syndrome in an oncological patient: a case report

Zeitschrift:
Wiener klinische Wochenschrift > Sonderheft 1/2014
Autoren:
Nora Wutte, Michael Palfner, Herbert Auer, Gerald Ruckenbauer, Thomas Valentin, Katharina Seeber, Werner Aberer, Ao. Univ. Prof. Dr. Robert Krause, Dr. Martin Hoenigl
Wichtige Hinweise
Nora Wutte and Michael Palfner contributed equally to this work.
Presented in part at the 46th Annual Meeting of the Austrian Society of Tropical Medicine and Parasitology 2012, Innsbruck, Austria and the International Meeting on Emerging Diseases and Surveillance (IMED) 2013, Vienna, Austria.

Summary

Toxocarosis is a parasitic infection caused by Toxocara canis or Toxocara cati. Their definite hosts are the domestic dog and cat, where their adult forms live within the lumen of the small intestine. In humans, infective larvae hatch after ingestion of eggs, but the juvenile stages fail to develop into mature adult worms. Instead, they migrate through the body with the potential to affect virtually every body site. DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a serious cutaneous drug reaction, which also involves other organ systems.
We report on a 45-year-old man who was admitted with fever up to 40 °C, skin rash and pruritus not responding to amoxicillin/clavulanic acid. Laboratory results showed a slightly elevated white blood cell count, with 62 % eosinophils. History revealed contact to roaming cats. Travel history was unremarkable. Extensive diagnostic workup was performed, and the patient was finally diagnosed with DRESS syndrome, responded to systemic corticosteroid therapy and was discharged. Serology for Toxocara came back positive a few days later. Stool was again sent for microscopy and was found positive for Giardia lamblia, which was treated with a 5-day course of metronidazole. The patient had again developed rash and eosinophilia (62 %). Total immunoglobulin (Ig)E was 1,689 U/l (normal limit: < 100 689 U/l). Follow-up serology showed a marked increase of Toxocara TES ELISA IgG (70 U, normal limit: < 20 U), confirming toxocarosis. Antiparasitic treatment with albendazole 400 mg bid for 5 days was initiated; eosinophilia resolved; and the patient had no further complaints.
Although generalized exanthema due to Toxocara has not yet been described in literature, toxocarosis is known to cause a wide spectrum of cutaneous manifestations. Whether our patient had both, a drug reaction with eosinophilia and systemic symptoms and a parasitic infection, or whether a hypersensitivity reaction to Toxocara antigen was mimicking a DRESS syndrome remains unclear.

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