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Erschienen in: Wiener klinische Wochenschrift 11-12/2015

01.06.2015 | original article

Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis

verfasst von: Ramazan Esen, Dr. Mehmet Aslan, Mehmet Emin Kucukoglu, Aytekin Cıkman, Umit Yakan, Mahmut Sunnetcioglu, Sahbettin Selek

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2015

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Summary

It is well known that paraoxonase-1 (PON1) activity may decrease during the course of infection and inflammation. The aim of this study was to investigate serum PON1 activity, oxidative status, and thiols levels in patients with acute brucellosis. In addition, we investigated the PON1 phenotype in patients with acute brucellosis. Thirty patients with acute brucellosis and 35 healthy controls were enrolled. Serum paraoxonase and arylesterase activities, thiols levels, lipid hydroperoxide levels, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Serum basal and salt-stimulated paraoxonase–arylesterase activities, TAC levels and thiols levels were significantly lower in patients with acute brucellosis than controls (for all, p < 0.05), while LOOH levels, TOS levels, and OSI values were significantly higher (for all, p < 0.05). We concluded that oxidative stress is increased, while serum PON1 activity is decreased in patients with acute brucellosis. These results indicate that lower PON1 activity is associated with oxidant–antioxidant imbalance.
Literatur
1.
Zurück zum Zitat Ertek M, Yazgı H, Kadanalı A, Özden K, Ta¸syaran MA. Complications of Brucella infection among adults: an 18-year retrospective evaluation. Turk J Med Sci. 2006;36:377–81. Ertek M, Yazgı H, Kadanalı A, Özden K, Ta¸syaran MA. Complications of Brucella infection among adults: an 18-year retrospective evaluation. Turk J Med Sci. 2006;36:377–81.
2.
Zurück zum Zitat Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352:2325–36. PubMedCrossRef Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352:2325–36. PubMedCrossRef
3.
Zurück zum Zitat Colmenero JD, Reguera JM, Martos F, et al. Complications associated with brucella melitensis infection: a study of 530 Cases. Medicine (Baltimore). 1996;75:195–211. CrossRef Colmenero JD, Reguera JM, Martos F, et al. Complications associated with brucella melitensis infection: a study of 530 Cases. Medicine (Baltimore). 1996;75:195–211. CrossRef
4.
Zurück zum Zitat Gantt KR, Goldman TL, McCormick ML, et al. Oxidative response of human and murine macrophages during phagocytosis of Leishmania chagasi. J Immunol. 2001;167:893–901. PubMedCrossRef Gantt KR, Goldman TL, McCormick ML, et al. Oxidative response of human and murine macrophages during phagocytosis of Leishmania chagasi. J Immunol. 2001;167:893–901. PubMedCrossRef
5.
Zurück zum Zitat Dieffenbach CW, Tramont EC. Innate (general or nonspecific) host defense mechanisms. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6. ed. Philadelphia: Elsevier Churchill Livingstone; 2005;34–42. Dieffenbach CW, Tramont EC. Innate (general or nonspecific) host defense mechanisms. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6. ed. Philadelphia: Elsevier Churchill Livingstone; 2005;34–42.
6.
Zurück zum Zitat Melek IM, Erdogan S, Celik S, Aslantas O, Duman T. Evaluation of oxidative stress and inflammation in long term Brucella melitensis infection. Mol Cell Biochem. 2006;293:203–9. PubMedCrossRef Melek IM, Erdogan S, Celik S, Aslantas O, Duman T. Evaluation of oxidative stress and inflammation in long term Brucella melitensis infection. Mol Cell Biochem. 2006;293:203–9. PubMedCrossRef
7.
Zurück zum Zitat Jiang X, Baldwin CL. Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide. Cell Immunol. 1993;151:309–19. PubMedCrossRef Jiang X, Baldwin CL. Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide. Cell Immunol. 1993;151:309–19. PubMedCrossRef
8.
Zurück zum Zitat Serefhanoglu K, Taskin A, Turan H, Timurkaynak FE, Arslan H, Erel O. Evaluation of oxidative status in patients with brucellosis. Braz J Infect Dis. 2009;13(4):249–51. PubMedCrossRef Serefhanoglu K, Taskin A, Turan H, Timurkaynak FE, Arslan H, Erel O. Evaluation of oxidative status in patients with brucellosis. Braz J Infect Dis. 2009;13(4):249–51. PubMedCrossRef
9.
Zurück zum Zitat Blatter MC, James RW, Messmer S, Barja F, Pometta D. Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase. Eur J Biochem. 1993;211:871–9. PubMedCrossRef Blatter MC, James RW, Messmer S, Barja F, Pometta D. Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase. Eur J Biochem. 1993;211:871–9. PubMedCrossRef
10.
Zurück zum Zitat Kosaka T, Yamaguchi M, Motomura T, Mizuno K. Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay. Clin Chim Acta. 2005;359:156–62. PubMedCrossRef Kosaka T, Yamaguchi M, Motomura T, Mizuno K. Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay. Clin Chim Acta. 2005;359:156–62. PubMedCrossRef
11.
Zurück zum Zitat Ng CJ, Shih DM, Hama SY, Villa N, NavabM, Reddy ST. The paraoxonase gene family and atherosclerosis. Free Radical Biol Med. 2005;38:153–63. CrossRef Ng CJ, Shih DM, Hama SY, Villa N, NavabM, Reddy ST. The paraoxonase gene family and atherosclerosis. Free Radical Biol Med. 2005;38:153–63. CrossRef
12.
Zurück zum Zitat Rozenberg O, Rosenblat M, Coleman R, Shih DM, Aviram M. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knock out mice. Free Radical Biol Med. 2003;34:774–84. CrossRef Rozenberg O, Rosenblat M, Coleman R, Shih DM, Aviram M. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knock out mice. Free Radical Biol Med. 2003;34:774–84. CrossRef
13.
Zurück zum Zitat Kotur-Stevuljevic J, Spasic S, Jelic-Ivanovic Z, et al. PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. Clin Biochem. 2008;41:1067–73. PubMedCrossRef Kotur-Stevuljevic J, Spasic S, Jelic-Ivanovic Z, et al. PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. Clin Biochem. 2008;41:1067–73. PubMedCrossRef
14.
Zurück zum Zitat Kabaroglu C, Mutaf I, Boydak B, et al. Association between serum paraoxonase activity and oxidative stress in acute coronary syndromes. Acta Cardiol. 2004;59(6):606–11. PubMedCrossRef Kabaroglu C, Mutaf I, Boydak B, et al. Association between serum paraoxonase activity and oxidative stress in acute coronary syndromes. Acta Cardiol. 2004;59(6):606–11. PubMedCrossRef
15.
Zurück zum Zitat Cabana VG, Reardon CA, Feng N, Neath S, Lukens J, Getz GS. Serum paraoxonase: effect of the apolipoprotein composition of HDL and the acute phase response. J Lipid Res. 2003;44:780–92. PubMedCrossRef Cabana VG, Reardon CA, Feng N, Neath S, Lukens J, Getz GS. Serum paraoxonase: effect of the apolipoprotein composition of HDL and the acute phase response. J Lipid Res. 2003;44:780–92. PubMedCrossRef
16.
Zurück zum Zitat Karakucuk S, Baskol G, Oner AO, Baskol M, Mirza E, Ustdal M. Serum paraoxonase activity is decreased in the active stage of Behcet’s disease. Br J Ophthalmol. 2004;88:1256–8. PubMedCentralPubMedCrossRef Karakucuk S, Baskol G, Oner AO, Baskol M, Mirza E, Ustdal M. Serum paraoxonase activity is decreased in the active stage of Behcet’s disease. Br J Ophthalmol. 2004;88:1256–8. PubMedCentralPubMedCrossRef
17.
Zurück zum Zitat Demirpence O, Sevim B, Yıldırım M, Ayan Nurlu N, Mert D, Evliyaoglu O. Serum paraoxonase, TAS, TOS and ceruloplasmin in brucellosis. Int J Clin Exp Med. 2014;7(6):1592–7. PubMedCentralPubMed Demirpence O, Sevim B, Yıldırım M, Ayan Nurlu N, Mert D, Evliyaoglu O. Serum paraoxonase, TAS, TOS and ceruloplasmin in brucellosis. Int J Clin Exp Med. 2014;7(6):1592–7. PubMedCentralPubMed
18.
Zurück zum Zitat Apostolou F, Gazi IF, Kostoula A, et al. Persistence of an atherogenic lipid profile after treatment of acute infection with brucella. J Lipid Res. 2009;50:2532–9. PubMedCentralPubMedCrossRef Apostolou F, Gazi IF, Kostoula A, et al. Persistence of an atherogenic lipid profile after treatment of acute infection with brucella. J Lipid Res. 2009;50:2532–9. PubMedCentralPubMedCrossRef
19.
Zurück zum Zitat Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radicalcation. Clin Biochem. 2004;37:277–85. PubMedCrossRef Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radicalcation. Clin Biochem. 2004;37:277–85. PubMedCrossRef
20.
Zurück zum Zitat Sodergren E, Nourooz-Zadeh J, Berglund L, Vessby B. Re-evaluation of the ferrous oxidation in xylenol orange assay for the measurement of plasma lipid hydroperoxides. J Biochem Biophys Methods. 1998;37(3):137–46. PubMedCrossRef Sodergren E, Nourooz-Zadeh J, Berglund L, Vessby B. Re-evaluation of the ferrous oxidation in xylenol orange assay for the measurement of plasma lipid hydroperoxides. J Biochem Biophys Methods. 1998;37(3):137–46. PubMedCrossRef
21.
Zurück zum Zitat Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37:112–9. PubMedCrossRef Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37:112–9. PubMedCrossRef
22.
Zurück zum Zitat Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103–11. PubMedCrossRef Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103–11. PubMedCrossRef
23.
Zurück zum Zitat Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis. 2005;5:95–101. PubMedCentralPubMedCrossRef Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis. 2005;5:95–101. PubMedCentralPubMedCrossRef
24.
Zurück zum Zitat Eckerson HW, Wyte MC, La Du BN. The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet. 1983;35:1126–38. PubMedCentralPubMed Eckerson HW, Wyte MC, La Du BN. The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet. 1983;35:1126–38. PubMedCentralPubMed
25.
Zurück zum Zitat Haagen L, Brock A. A new automated method for phenotyping arylesterase (E.C. 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clim Biochem. 1992;30:391–5. Haagen L, Brock A. A new automated method for phenotyping arylesterase (E.C. 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clim Biochem. 1992;30:391–5.
26.
Zurück zum Zitat Nourooz Zadeh J. Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma. Methods Enzymol. 1999;300:58–62. PubMed Nourooz Zadeh J. Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma. Methods Enzymol. 1999;300:58–62. PubMed
27.
Zurück zum Zitat Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol. 1994;233:381–5. Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol. 1994;233:381–5.
28.
Zurück zum Zitat Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6. ed. Philadelphia: Elsevier Churchill Livingstone; 2005;2669–74. Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6. ed. Philadelphia: Elsevier Churchill Livingstone; 2005;2669–74.
29.
Zurück zum Zitat Niemela S, Karttunen T, Korhonen T, et al. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart. 1996;75:573–5. PubMedCentralPubMedCrossRef Niemela S, Karttunen T, Korhonen T, et al. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart. 1996;75:573–5. PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Hoffmeister A, Rothenbacher D, Bode G, et al. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arterioscler Thromb Vasc Biol. 2001;21:427–32. PubMedCrossRef Hoffmeister A, Rothenbacher D, Bode G, et al. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arterioscler Thromb Vasc Biol. 2001;21:427–32. PubMedCrossRef
31.
Zurück zum Zitat Altintas E, Ucbilek E, Ulu O, Sezgin O, Uzer C. Helicobacter pylori associated atrophic gastritis and carotid intima-media thickness, is there a link? Int Clin Pract. 2007;61(5):810–4. CrossRef Altintas E, Ucbilek E, Ulu O, Sezgin O, Uzer C. Helicobacter pylori associated atrophic gastritis and carotid intima-media thickness, is there a link? Int Clin Pract. 2007;61(5):810–4. CrossRef
32.
Zurück zum Zitat Van Leeuwen, HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med. 2003;31:1359–66. PubMedCrossRef Van Leeuwen, HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med. 2003;31:1359–66. PubMedCrossRef
33.
Zurück zum Zitat Aslan M, Nazligul Y, Horoz M, et al. Serum paraoxonase-1 activity in Helicobacter pylori infected subjects. Atherosclerosis. 2008;196:270–4. PubMedCrossRef Aslan M, Nazligul Y, Horoz M, et al. Serum paraoxonase-1 activity in Helicobacter pylori infected subjects. Atherosclerosis. 2008;196:270–4. PubMedCrossRef
34.
Zurück zum Zitat Mackness B, Mackness MI, Arrol S, et al. Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus. Atherosclerosis. 1998;139:341–9. PubMedCrossRef Mackness B, Mackness MI, Arrol S, et al. Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus. Atherosclerosis. 1998;139:341–9. PubMedCrossRef
35.
Zurück zum Zitat Quemeneur T, Martin-Nizard F, Kandoussi A, et al. PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis. Semin Arthritis Rheum. 2007;37:149–55. PubMedCrossRef Quemeneur T, Martin-Nizard F, Kandoussi A, et al. PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis. Semin Arthritis Rheum. 2007;37:149–55. PubMedCrossRef
36.
Zurück zum Zitat Mackness MI, Harty D, Bhatnagar D, et al. Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus. Atherosclerosis. 1991;86:193–9. PubMedCrossRef Mackness MI, Harty D, Bhatnagar D, et al. Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus. Atherosclerosis. 1991;86:193–9. PubMedCrossRef
37.
Zurück zum Zitat Rizzo M, Kotur-Stevuljevic J, Berneis K, Spasojevic- Kalimanovska V, Vekic J. Atherogenic dyslipidemia and oxidative stress: a new look. Transl Res. 2009;153:217–23. PubMedCrossRef Rizzo M, Kotur-Stevuljevic J, Berneis K, Spasojevic- Kalimanovska V, Vekic J. Atherogenic dyslipidemia and oxidative stress: a new look. Transl Res. 2009;153:217–23. PubMedCrossRef
38.
39.
Zurück zum Zitat La Du BN, Aviram M, Billecke S, et al. On the physiological role(s) of the paraoxonases. Chem Biol Interact. 1999;119–120:379–88. PubMedCrossRef La Du BN, Aviram M, Billecke S, et al. On the physiological role(s) of the paraoxonases. Chem Biol Interact. 1999;119–120:379–88. PubMedCrossRef
40.
Zurück zum Zitat Ali EM, Shehata HH, Ali-Labib R, Esmail Zahra LM. Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus. Clin Biochem. 2009;42:1394–1400. PubMedCrossRef Ali EM, Shehata HH, Ali-Labib R, Esmail Zahra LM. Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus. Clin Biochem. 2009;42:1394–1400. PubMedCrossRef
41.
Zurück zum Zitat Ates O, Azizi S, Alp HH, Kiziltunc A, Kocer I, Baykal O. Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Tohoku J Exp Med. 2009;217:17–22. PubMedCrossRef Ates O, Azizi S, Alp HH, Kiziltunc A, Kocer I, Baykal O. Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Tohoku J Exp Med. 2009;217:17–22. PubMedCrossRef
42.
Zurück zum Zitat Kilic SS, Aydin S, Kilic N, Erman F, Aydin S, Celik I. Serum arylesterase and paraoxonase activity in patients with chronic hepatitis. World J Gastroenterol. 2005;11:7351–4. PubMed Kilic SS, Aydin S, Kilic N, Erman F, Aydin S, Celik I. Serum arylesterase and paraoxonase activity in patients with chronic hepatitis. World J Gastroenterol. 2005;11:7351–4. PubMed
43.
Zurück zum Zitat Parra S, Alonso-Villaverde C, Coll B, et al. Serum paraoxonase-1 activity and concentration are infl uenced by human immunodefi ciency virus infection. Atherosclerosis. 2007;194:175–81. PubMedCrossRef Parra S, Alonso-Villaverde C, Coll B, et al. Serum paraoxonase-1 activity and concentration are infl uenced by human immunodefi ciency virus infection. Atherosclerosis. 2007;194:175–81. PubMedCrossRef
44.
Zurück zum Zitat Aviram M, Rosenblat M, Billecke S, et al. Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radical Biol Med. 1999;26:892–904. CrossRef Aviram M, Rosenblat M, Billecke S, et al. Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radical Biol Med. 1999;26:892–904. CrossRef
45.
Zurück zum Zitat Dirican M, Akca R, Sarandol E, Dilek K. Serum paraoxonase activity in uremic predialysis and hemodialysis patients. J Nephrol. 2004;17:813–8. PubMed Dirican M, Akca R, Sarandol E, Dilek K. Serum paraoxonase activity in uremic predialysis and hemodialysis patients. J Nephrol. 2004;17:813–8. PubMed
46.
Zurück zum Zitat Mackness B, Durington P, McElduff P, et al. Low paraoxonase activity predicts coronary events in the caterphilly prospective study. Circulation. 2003;107:2775–9. PubMedCrossRef Mackness B, Durington P, McElduff P, et al. Low paraoxonase activity predicts coronary events in the caterphilly prospective study. Circulation. 2003;107:2775–9. PubMedCrossRef
47.
Zurück zum Zitat Sutherland WHF, Walker RJ, de Jong SA, van Rij AM, Phillips V, Walker HL. Reduced postprandial serum paraoxonase activity after meal rich in used cooking fat. Arterioscler Thromb Vasc Biol. 1999;19:1340–7. PubMedCrossRef Sutherland WHF, Walker RJ, de Jong SA, van Rij AM, Phillips V, Walker HL. Reduced postprandial serum paraoxonase activity after meal rich in used cooking fat. Arterioscler Thromb Vasc Biol. 1999;19:1340–7. PubMedCrossRef
48.
Zurück zum Zitat Van der Gaag MS, van Tol A, Scheek LM, et al. Daily moderate alcohol consumption increases serum paraoxonase activity; a diet controlled, randomized intervention study in middle-aged men. Atherosclerosis. 1999;147:405–10. Van der Gaag MS, van Tol A, Scheek LM, et al. Daily moderate alcohol consumption increases serum paraoxonase activity; a diet controlled, randomized intervention study in middle-aged men. Atherosclerosis. 1999;147:405–10.
49.
Zurück zum Zitat Chandra M, Chandra N, Agrawal R, Kumar A, Ghatak A, Pandey VC. The free radical system in ischemic heart disease. Int J Cardiol. 1994;43:121–5. PubMedCrossRef Chandra M, Chandra N, Agrawal R, Kumar A, Ghatak A, Pandey VC. The free radical system in ischemic heart disease. Int J Cardiol. 1994;43:121–5. PubMedCrossRef
50.
Zurück zum Zitat Jarvik GP, Tsai NT, McKinstry LA, et al. Vitamin C and E intake is associated with increased paraoxonase activity. Arterioscler Thromb Vasc Biol. 2004;22:1329–33. CrossRef Jarvik GP, Tsai NT, McKinstry LA, et al. Vitamin C and E intake is associated with increased paraoxonase activity. Arterioscler Thromb Vasc Biol. 2004;22:1329–33. CrossRef
51.
Zurück zum Zitat Kakafika AI, Xenofontos S, Tsimihodimos V, et al. The PON1 M55 L gene polymorphism is associated with reduced HDL-associated PAF-AH activity. J Lipid Res. 2003;44:1919–26. PubMedCrossRef Kakafika AI, Xenofontos S, Tsimihodimos V, et al. The PON1 M55 L gene polymorphism is associated with reduced HDL-associated PAF-AH activity. J Lipid Res. 2003;44:1919–26. PubMedCrossRef
52.
Zurück zum Zitat Aslan M, Kosecik M, Horoz M, Selek S, Celik H, Erel O. Assessment of paraoxonase and arylesterase activities in patientswith iron deficiency anemia. Atherosclerosis. 2007;191:397–402. PubMedCrossRef Aslan M, Kosecik M, Horoz M, Selek S, Celik H, Erel O. Assessment of paraoxonase and arylesterase activities in patientswith iron deficiency anemia. Atherosclerosis. 2007;191:397–402. PubMedCrossRef
53.
Zurück zum Zitat Li HL, Liu DP, Liang CC. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med. 2003;81(12):766–79. PubMedCrossRef Li HL, Liu DP, Liang CC. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med. 2003;81(12):766–79. PubMedCrossRef
54.
Zurück zum Zitat Sepahvand F, Shafiei M, Ghaffari SM, Rahimi-Moghaddam P, Mahmoudian M. Paraoxonase phenotype distribution in a healthy Iranian population. Basic Clin Pharmacol Toxicol. 2007;101:104–7. PubMedCrossRef Sepahvand F, Shafiei M, Ghaffari SM, Rahimi-Moghaddam P, Mahmoudian M. Paraoxonase phenotype distribution in a healthy Iranian population. Basic Clin Pharmacol Toxicol. 2007;101:104–7. PubMedCrossRef
55.
Zurück zum Zitat Mackness B, Davies GK, Turkie W, et al. Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?. Arterioscler Thromb Vasc Biol. 2001;21:1451–7. PubMedCrossRef Mackness B, Davies GK, Turkie W, et al. Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?. Arterioscler Thromb Vasc Biol. 2001;21:1451–7. PubMedCrossRef
Metadaten
Titel
Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis
verfasst von
Ramazan Esen
Dr. Mehmet Aslan
Mehmet Emin Kucukoglu
Aytekin Cıkman
Umit Yakan
Mahmut Sunnetcioglu
Sahbettin Selek
Publikationsdatum
01.06.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0720-z