The purpose of the study was to compare our experience to recent trends of multimodal treatment of patients with locally advanced rectal cancer.
Patients and methods
209 patients with histologically proven adenocarcinoma of the rectum were treated for 3 years by a multimodal approach in a single center. Patients were evaluated for clinical and pathologic response. The type of surgical procedure and the number of retrieved lymph nodes and postoperative complications were recorded.
Neoadjuvant Chemoradiotherapy (CRT) had a downstaging effect in more than half of our patients (50.61 %), and about one quarter of them achieved a complete pathologic response (22.22 %).
Preoperative CRT produced an encouraging down-staging effect with acceptable toxicity and perioperative complications.