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01.05.2016 | ICS congress 2015 | Sonderheft 2/2016

European Surgery 2/2016

Predictive factors of non-sentinel lymph node involvement in breast cancer patients with positive sentinel lymph nodes; a 5‑year single centre experience

Zeitschrift:
European Surgery > Sonderheft 2/2016
Autoren:
D. Dyttert, P. Chvalný, M. Sabol, I. Waczulíková, V. Rekeň, L. Arciniegas, Š. Nemergut, Š. Durdík
Wichtige Hinweise
The supplement is dedicated to Jubilee World congress of International College of Surgeons 2015.
The publishing was sponsored by the Ministry of Health of the Czech Republic.

Abstract

Background

The aim of our study was to determine the number of sentinel nodes (SN) and non-sentinel nodes (NSN) involved and to identify predictive factors of non-sentinel lymph node involvement in breast cancer patients.

Methods

The analysis was performed retrospectively on 1350 patients referred for sentinel lymph node biopsy (SLNB) during the 5-year period 2010–2014.

Results

Metastatic involvement of SN was found in 286 patients (21 %). A subgroup of 274 (96 %) patients, of whom 90 (33 %) had NSN involvement, underwent axillary lymph node dissection (ALND). A prediction model was developed using the significant predictors detected by the univariate analysis.

Conclusion

The most important predictive factors of NSN involvement were the ratio of positive-to-removed SN, size of metastases and a tumour lympho-vascular invasion (LVI). The model may serve to optimize treatment strategies for patients presenting more of the identified risk factors for NSN involvement.

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