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Erschienen in: European Surgery 2/2016

01.05.2016 | ICS congress 2015

Predictive factors of non-sentinel lymph node involvement in breast cancer patients with positive sentinel lymph nodes; a 5‑year single centre experience

verfasst von: D. Dyttert, P. Chvalný, M. Sabol, I. Waczulíková, V. Rekeň, L. Arciniegas, Š. Nemergut, Š. Durdík

Erschienen in: European Surgery | Sonderheft 2/2016

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Abstract

Background

The aim of our study was to determine the number of sentinel nodes (SN) and non-sentinel nodes (NSN) involved and to identify predictive factors of non-sentinel lymph node involvement in breast cancer patients.

Methods

The analysis was performed retrospectively on 1350 patients referred for sentinel lymph node biopsy (SLNB) during the 5-year period 2010–2014.

Results

Metastatic involvement of SN was found in 286 patients (21 %). A subgroup of 274 (96 %) patients, of whom 90 (33 %) had NSN involvement, underwent axillary lymph node dissection (ALND). A prediction model was developed using the significant predictors detected by the univariate analysis.

Conclusion

The most important predictive factors of NSN involvement were the ratio of positive-to-removed SN, size of metastases and a tumour lympho-vascular invasion (LVI). The model may serve to optimize treatment strategies for patients presenting more of the identified risk factors for NSN involvement.
Literatur
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Zurück zum Zitat Lyman GH, Temin S, Edge SB, Newman LA, Turner RR, Weaver DL, et al. Sentinel lymph node biopsy for patients with early-stage breast cancer: american society of clinical oncology clinical practice guideline update. J Clin Oncol. 2014;32(13):1365–1383. CrossRefPubMed Lyman GH, Temin S, Edge SB, Newman LA, Turner RR, Weaver DL, et al. Sentinel lymph node biopsy for patients with early-stage breast cancer: american society of clinical oncology clinical practice guideline update. J Clin Oncol. 2014;32(13):1365–1383. CrossRefPubMed
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Zurück zum Zitat Šťastný K, Červinka V, Šiller J, Havlíček K, Gatěk J, Vachtová M, et al. Predictive factors for non-sentinel lymph nodes affection in breast carcinoma–outcomes of a Czech multicenter study of sentinel lymph nodes. Rozhl Chir. 2011;90(6):348–351, http://​europepmc.​org/​abstract/​MED/​22026102. Accessed 2 June 2015. Šťastný K, Červinka V, Šiller J, Havlíček K, Gatěk J, Vachtová M, et al. Predictive factors for non-sentinel lymph nodes affection in breast carcinoma–outcomes of a Czech multicenter study of sentinel lymph nodes. Rozhl Chir. 2011;90(6):348–351, http://​europepmc.​org/​abstract/​MED/​22026102. Accessed 2 June 2015.
Metadaten
Titel
Predictive factors of non-sentinel lymph node involvement in breast cancer patients with positive sentinel lymph nodes; a 5‑year single centre experience
verfasst von
D. Dyttert
P. Chvalný
M. Sabol
I. Waczulíková
V. Rekeň
L. Arciniegas
Š. Nemergut
Š. Durdík
Publikationsdatum
01.05.2016
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe Sonderheft 2/2016
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-016-0400-x

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