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01.04.2015 | review | Ausgabe 1/2015

memo - Magazine of European Medical Oncology 1/2015

Predicting drug sensitivity by 3D cell culture models

Zeitschrift:
memo - Magazine of European Medical Oncology > Ausgabe 1/2015
Autoren:
MD Arno Amann, MD Gabriele Gamerith, PhD Julia M. Huber, MD Marit Zwierzina, MD Wolfgang Hilbe, MD Heinz Zwierzina

Abstract

Because of recent failures of novel drugs in phase II and III trials innovative in vitro models are needed that may predict drug efficacy in patients. Although, numerous modifications of traditional cell culture and animal models were undertaken significant improvements in cell culture- based drug development have not been achieved. Three-dimensional (3D) cell culture may represents an modern alternative to bridge the gap between 2D cell cultures and animal models.

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