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01.06.2016 | original article | Ausgabe 11-12/2016

Wiener klinische Wochenschrift 11-12/2016

Crizotinib-induced toxicity in an experimental rat model

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 11-12/2016
Autoren:
MD Ozge Gumusay, Guldal Esendagli-Yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet Ozet

Summary

Aim

The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model.

Methods

Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively.

Results

Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas.

Conclusion

This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.

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