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Cilastatin does not affect Carba NP test performance for detection of carbapenemase production in Enterobacteriaceae

Zeitschrift:: Wiener klinische Wochenschrift > Ausgabe 1-2/2017

Autoren:: Dr. Rainer Hartl, Sarah Widhalm, Dr. Heidrun Kerschner, Univ. Prof. Petra Apfalter, Dr. Rainer Gattringer

Summary

The Carba NP test is a simple confirmation method for carbapenemase-producing Enterobacteriaceae (CPE) but reagents have to be freshly prepared as imipenem sodium salt is unstable. We evaluated the Carba NP test performance based on a commercially available 10-fold cheaper drug formulation containing cilastatin against 217 CPE and 78 non-CPE isolates with reduced meropenem susceptibility. Specificity and sensitivity were 100 % and 98.6 %, respectively and 3 false negative results of blaVIM-1-producing Proteus mirabilis were reproducible with the RAPIDEC® Carba NP test. Cilastatin does not disturb test performance provided that the imipenem drug quantity is doubled.

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Titel: Cilastatin does not affect Carba NP test performance for detection of carbapenemase production in Enterobacteriaceae
Autoren:: Dr. Rainer Hartl
Sarah Widhalm
Dr. Heidrun Kerschner
Univ. Prof. Petra Apfalter
Dr. Rainer Gattringer
Publikationsdatum: 01.01.2017
DOI: https://doi.org/10.1007/s00508-016-1106-6
Verlag: Springer Vienna
Zeitschrift: Wiener klinische Wochenschrift The Central European Journal of Medicine
Ausgabe 1-2/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671

Springer Medizin Österreich

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