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Erschienen in: Wiener klinische Wochenschrift 1-2/2017

01.01.2017 | original article

Cilastatin does not affect Carba NP test performance for detection of carbapenemase production in Enterobacteriaceae

verfasst von: Dr. Rainer Hartl, Sarah Widhalm, Dr. Heidrun Kerschner, Univ. Prof. Petra Apfalter, Dr. Rainer Gattringer

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2017

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Summary

The Carba NP test is a simple confirmation method for carbapenemase-producing Enterobacteriaceae (CPE) but reagents have to be freshly prepared as imipenem sodium salt is unstable. We evaluated the Carba NP test performance based on a commercially available 10-fold cheaper drug formulation containing cilastatin against 217 CPE and 78 non-CPE isolates with reduced meropenem susceptibility. Specificity and sensitivity were 100 % and 98.6 %, respectively and 3 false negative results of blaVIM-1-producing Proteus mirabilis were reproducible with the RAPIDEC® Carba NP test. Cilastatin does not disturb test performance provided that the imipenem drug quantity is doubled.
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Metadaten
Titel
Cilastatin does not affect Carba NP test performance for detection of carbapenemase production in Enterobacteriaceae
verfasst von
Dr. Rainer Hartl
Sarah Widhalm
Dr. Heidrun Kerschner
Univ. Prof. Petra Apfalter
Dr. Rainer Gattringer
Publikationsdatum
01.01.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1106-6