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Chemotherapies and future directions in metastatic colorectal cancer

Zeitschrift:: memo - Magazine of European Medical Oncology > Ausgabe 3/2017

Autor:: PhD PD Dr. Thomas Winder

Summary

Substantial progress has been achieved in the management of metastatic colorectal cancer (mCRC) over the last two decades. The overall survival has increased from 10 months to more than 30 months. These improvements are due to the integration of multiple cytotoxic agents and targeted therapies, as well as individualized treatment strategies using molecular and clinical factors. More specific, molecular characteristics such as RAS mutation status and clinical factors such as performance status, tumor burden, tumor-related symptoms and comorbidities are crucial in selecting treatment strategies. Here I review the landscape of cytotoxic chemotherapy for mCRC, regional chemotherapy strategies to accumulate cytotoxics within the tumor and reflect on future directions for treatment of mCRC.

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Titel: Chemotherapies and future directions in metastatic colorectal cancer
Autor:: PhD PD Dr. Thomas Winder
Publikationsdatum: 01.09.2017
DOI: https://doi.org/10.1007/s12254-017-0351-3
Verlag: Springer Vienna
Zeitschrift: memo - Magazine of European Medical Oncology An International Journal for Oncology and Haematology Professionals
Ausgabe 3/2017
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076

Springer Medizin Österreich

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