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27.07.2017 | original article

Citicoline in severe traumatic brain injury: indications for improved outcome

A retrospective matched pair analysis from 14 Austrian trauma centers

verfasst von: Helmut Trimmel, Marek Majdan, Andrea Wodak, Guenther Herzer, Daniel Csomor, Alexandra Brazinova

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2018

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Summary

Goal-oriented management of traumatic brain injury (TBI) can save the lives and/or improve the long-term outcome of millions of affected patients worldwide. Additionally, enhancing quality of life will save enormous socio-economic costs; however, promising TBI treatment strategies with neuroprotective agents, such as citicoline (CDP-choline), lacked evidence or produced contradictory results in clinical trials. During a prehospital TBI project to optimize early TBI care within 14 Austrian trauma centers, data on 778 TBI patients were prospectively collected. As preceding evaluations suggested a beneficial outcome in TBI patients treated at the Wiener Neustadt Hospital (WNH), we aimed to investigate the potential role of citicoline administration, solely applied in WNH, in those patients. In a retrospective subgroup analysis we compared 67 patients from WNH with citicoline administration and 67 matched patients from other Austrian centers without citicoline use. Patients with Glasgow Coma Scale score <13 on site and/or Abbreviated Injury Scale of the region “head” >2 were included. Our analysis revealed significantly reduced rates of intensive care unit (ICU) mortality (5% vs. 24%, p < 0.01), in-hospital mortality (9% vs. 24%, p = 0.035) and 6‑month mortality (13% vs. 28%, p = 0.031), as well as of unfavorable outcome (34% vs. 57%, p = 0.015) and observed vs. expected ratio for mortality (0.42 vs. 0.84) in the WNH (citicoline receivers) group. Despite the limitations of a retrospective subgroup analysis our findings suggest a possible correlation between early and consequent citicoline administration and beneficial outcomes. Therefore, we aim to set up an initiative for a prospective, multicenter randomized controlled trial with citicoline in sTBI (severe TBI) patients.
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Literatur
1.
Zurück zum Zitat Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation. 2007;22(5):341–53.PubMed Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation. 2007;22(5):341–53.PubMed
2.
Zurück zum Zitat Mauritz W, Brazinova A, Majdan M, Leitgeb J. Epidemiology of traumatic brain injury in Austria. Wien Klin Wochenschr. 2014;126(1–2):42–52.CrossRefPubMed Mauritz W, Brazinova A, Majdan M, Leitgeb J. Epidemiology of traumatic brain injury in Austria. Wien Klin Wochenschr. 2014;126(1–2):42–52.CrossRefPubMed
3.
Zurück zum Zitat Andriessen TM, Jacobs B, Vos PE. Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury. J Cell Mol Med. 2010;14(10):2381–92.CrossRefPubMedPubMedCentral Andriessen TM, Jacobs B, Vos PE. Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury. J Cell Mol Med. 2010;14(10):2381–92.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Dhillon HS, Dose JM, Scheff SW, Prasad MR. Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. Exp Neurol. 1997;146(1):240–9.CrossRefPubMed Dhillon HS, Dose JM, Scheff SW, Prasad MR. Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. Exp Neurol. 1997;146(1):240–9.CrossRefPubMed
5.
Zurück zum Zitat Baskaya MK, Dogan A, Rao AM, Dempsey RJ. Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg. 2000;92(3):448–52.CrossRefPubMed Baskaya MK, Dogan A, Rao AM, Dempsey RJ. Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg. 2000;92(3):448–52.CrossRefPubMed
6.
Zurück zum Zitat Dixon CE, Bao J, Long DA, Hayes RL. Reduced evoked release of acetylcholine in the rodent hippocampus following traumatic brain injury. Pharmacol Biochem Behav. 1996;53(3):679–86.CrossRefPubMed Dixon CE, Bao J, Long DA, Hayes RL. Reduced evoked release of acetylcholine in the rodent hippocampus following traumatic brain injury. Pharmacol Biochem Behav. 1996;53(3):679–86.CrossRefPubMed
7.
Zurück zum Zitat Dixon CE, Ma X, Marion DW. Reduced evoked release of acetylcholine in the rodent neocortex following traumatic brain injury. Brain Res. 1997;749(1):127–30.CrossRefPubMed Dixon CE, Ma X, Marion DW. Reduced evoked release of acetylcholine in the rodent neocortex following traumatic brain injury. Brain Res. 1997;749(1):127–30.CrossRefPubMed
9.
Zurück zum Zitat Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol. 2011;52(Suppl 2):S1–S62.PubMed Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol. 2011;52(Suppl 2):S1–S62.PubMed
10.
Zurück zum Zitat Blount PJ, Nguyen CD, McDeavitt JT. Clinical use of cholinomimetic agents: a review. J Head Trauma Rehabil. 2002;17(4):314–21.CrossRefPubMed Blount PJ, Nguyen CD, McDeavitt JT. Clinical use of cholinomimetic agents: a review. J Head Trauma Rehabil. 2002;17(4):314–21.CrossRefPubMed
11.
Zurück zum Zitat Lopez GCI, Agut J, Von Borstel R, Wurtman RJ. Metabolism of cytidine (5′)-diphosphocholine (cdp-choline) following oral and intravenous administration to the human and the rat. Neurochem Int. 1987;11(3):293–7.CrossRef Lopez GCI, Agut J, Von Borstel R, Wurtman RJ. Metabolism of cytidine (5′)-diphosphocholine (cdp-choline) following oral and intravenous administration to the human and the rat. Neurochem Int. 1987;11(3):293–7.CrossRef
12.
Zurück zum Zitat Dixon CE, Ma X, Marion DW. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J Neurotrauma. 1997;14(3):161–9.CrossRefPubMed Dixon CE, Ma X, Marion DW. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J Neurotrauma. 1997;14(3):161–9.CrossRefPubMed
13.
Zurück zum Zitat Lopez GCI, Agut J, Ortiz JA, Wurtman RJ. Effects of orally administered cytidine 5′-diphosphate choline on brain phospholipid content. J Nutr Biochem. 1992;3(6):313–5.CrossRef Lopez GCI, Agut J, Ortiz JA, Wurtman RJ. Effects of orally administered cytidine 5′-diphosphate choline on brain phospholipid content. J Nutr Biochem. 1992;3(6):313–5.CrossRef
14.
Zurück zum Zitat G-Coviella I, Wurtman RJ. Enhancement by cytidine of membrane phospholipid synthesis. J Neurochem. 1992;59(1):338–43.CrossRefPubMed G-Coviella I, Wurtman RJ. Enhancement by cytidine of membrane phospholipid synthesis. J Neurochem. 1992;59(1):338–43.CrossRefPubMed
15.
Zurück zum Zitat Dorman RV, Dabrowiecki Z, Horrocks LA. Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. J Neurochem. 1983;40(1):276–9.CrossRefPubMed Dorman RV, Dabrowiecki Z, Horrocks LA. Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. J Neurochem. 1983;40(1):276–9.CrossRefPubMed
16.
17.
Zurück zum Zitat Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J Neurochem. 1995;64(1):378–84.CrossRefPubMed Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J Neurochem. 1995;64(1):378–84.CrossRefPubMed
18.
Zurück zum Zitat Le Poncin-Lafitte M, Duterte D, Lageron A, Rapin JR. CDP choline and experimental cerebrovascular disorder. Agressologie. 1986;27(5):413–6.PubMed Le Poncin-Lafitte M, Duterte D, Lageron A, Rapin JR. CDP choline and experimental cerebrovascular disorder. Agressologie. 1986;27(5):413–6.PubMed
19.
Zurück zum Zitat Ma X, Zhang H, Pan Q, Zhao Y, Chen J, Zhao B, et al. Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. PLOS ONE. 2013;8(12):e82604.CrossRefPubMedPubMedCentral Ma X, Zhang H, Pan Q, Zhao Y, Chen J, Zhao B, et al. Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. PLOS ONE. 2013;8(12):e82604.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Spiers PA, Hochanadel G. Citicoline for traumatic brain injury: report of two cases, including my own. J Int Neuropsychol Soc. 1999;5(3):260–4.CrossRefPubMed Spiers PA, Hochanadel G. Citicoline for traumatic brain injury: report of two cases, including my own. J Int Neuropsychol Soc. 1999;5(3):260–4.CrossRefPubMed
21.
Zurück zum Zitat Lazowski T, Kierul K, Bartnicki M, Mayzner-Zawadzka E, Toczylowska B, Ryba M, et al. Effects of citicoline treatment in patients with isolated head trauma: a randomized trial. Crit Care. 2003;7(2):1. Lazowski T, Kierul K, Bartnicki M, Mayzner-Zawadzka E, Toczylowska B, Ryba M, et al. Effects of citicoline treatment in patients with isolated head trauma: a randomized trial. Crit Care. 2003;7(2):1.
22.
Zurück zum Zitat Zafonte RD, Bagiella E, Ansel BM, Novack TA, Friedewald WT, Hesdorffer DC, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012;308(19):1993–2000.CrossRefPubMed Zafonte RD, Bagiella E, Ansel BM, Novack TA, Friedewald WT, Hesdorffer DC, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012;308(19):1993–2000.CrossRefPubMed
23.
Zurück zum Zitat Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. Altern Med Rev. 2004;9(1):17–31.PubMed Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. Altern Med Rev. 2004;9(1):17–31.PubMed
24.
Zurück zum Zitat Clark WM, Warach SJ, Pettigrew LC, Gammans RE, Sabounjian LA, Citicoline Stroke Study Group. A randomized dose-response trial of citicoline in acute ischemic stroke patients. Neurology. 1997;49(3):671–8. doi:10.1212/wnl.49.3.671.CrossRefPubMed Clark WM, Warach SJ, Pettigrew LC, Gammans RE, Sabounjian LA, Citicoline Stroke Study Group. A randomized dose-response trial of citicoline in acute ischemic stroke patients. Neurology. 1997;49(3):671–8. doi:10.​1212/​wnl.​49.​3.​671.CrossRefPubMed
25.
Zurück zum Zitat Brazinova A, Majdan M, Leitgeb J, Trimmel H, Mauritz W. Factors that may improve outcomes of early traumatic brain injury care: prospective multicenter study in Austria. Scand J Trauma Resusc Emerg Med. 2015;23(1):53.CrossRefPubMedPubMedCentral Brazinova A, Majdan M, Leitgeb J, Trimmel H, Mauritz W. Factors that may improve outcomes of early traumatic brain injury care: prospective multicenter study in Austria. Scand J Trauma Resusc Emerg Med. 2015;23(1):53.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Garthe E, States JD, Mango NK. Abbreviated injury scale unification: the case for a unified injury system for global use. J Trauma. 1999;47(2):309–23.CrossRefPubMed Garthe E, States JD, Mango NK. Abbreviated injury scale unification: the case for a unified injury system for global use. J Trauma. 1999;47(2):309–23.CrossRefPubMed
28.
Zurück zum Zitat Marmarou A, Lu J, Butcher I, McHugh GS, Murray GD, Steyerberg EW, et al. Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis. J Neurotrauma. 2007;24(2):270–80.CrossRefPubMed Marmarou A, Lu J, Butcher I, McHugh GS, Murray GD, Steyerberg EW, et al. Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis. J Neurotrauma. 2007;24(2):270–80.CrossRefPubMed
29.
Zurück zum Zitat Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15(8):573–85.CrossRefPubMed Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15(8):573–85.CrossRefPubMed
30.
Zurück zum Zitat Teasdale GM, Pettigrew LE, Wilson JT, Murray G, Jennett B. Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. J Neurotrauma. 1998;15(8):587–97.CrossRefPubMed Teasdale GM, Pettigrew LE, Wilson JT, Murray G, Jennett B. Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. J Neurotrauma. 1998;15(8):587–97.CrossRefPubMed
31.
Zurück zum Zitat Calatayud Maldonado VC, Calatayud Perez JB, Aso Escario J. Effects of CDP-choline on the recovery of patients with head injury. J Neurol Sci. 1991;103(Suppl):S15–S8.CrossRefPubMed Calatayud Maldonado VC, Calatayud Perez JB, Aso Escario J. Effects of CDP-choline on the recovery of patients with head injury. J Neurol Sci. 1991;103(Suppl):S15–S8.CrossRefPubMed
32.
Zurück zum Zitat Hukkelhoven CW, Steyerberg EW, Rampen AJ, Farace E, Habbema JD, Marshall LF, et al. Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J Neurosurg. 2003;99(4):666–73.CrossRefPubMed Hukkelhoven CW, Steyerberg EW, Rampen AJ, Farace E, Habbema JD, Marshall LF, et al. Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J Neurosurg. 2003;99(4):666–73.CrossRefPubMed
33.
Zurück zum Zitat Maas AI, Hukkelhoven CW, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors. Neurosurgery. 2005;57(6):1173–82, discussion –1182.CrossRefPubMed Maas AI, Hukkelhoven CW, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors. Neurosurgery. 2005;57(6):1173–82, discussion –1182.CrossRefPubMed
34.
Zurück zum Zitat Boyd CR, Tolson MA, Copes WS. Evaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score. J Trauma. 1987;27(4):370–8.CrossRefPubMed Boyd CR, Tolson MA, Copes WS. Evaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score. J Trauma. 1987;27(4):370–8.CrossRefPubMed
35.
Zurück zum Zitat Majdan M, Lingsma HF, Nieboer D, Mauritz W, Rusnak M, Steyerberg EW. Performance of IMPACT, CRASH and Nijmegen models in predicting six month outcome of patients with severe or moderate TBI: an external validation study. Scand J Trauma Resusc Emerg Med. 2014;22:68.CrossRefPubMedPubMedCentral Majdan M, Lingsma HF, Nieboer D, Mauritz W, Rusnak M, Steyerberg EW. Performance of IMPACT, CRASH and Nijmegen models in predicting six month outcome of patients with severe or moderate TBI: an external validation study. Scand J Trauma Resusc Emerg Med. 2014;22:68.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Maas AI, Marmarou A, Murray GD, Teasdale SG, Steyerberg EW. Prognosis and clinical trial design in traumatic brain injury: the IMPACT study. J Neurotrauma. 2007;24(2):232–8.CrossRefPubMed Maas AI, Marmarou A, Murray GD, Teasdale SG, Steyerberg EW. Prognosis and clinical trial design in traumatic brain injury: the IMPACT study. J Neurotrauma. 2007;24(2):232–8.CrossRefPubMed
37.
Zurück zum Zitat Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24(Suppl 1):S1–S106. Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24(Suppl 1):S1–S106.
38.
Zurück zum Zitat Herzer G, Illievich U, Voelckel WG, Trimmel H. Current practice in neurocritical care of patients with subarachnoid haemorrhage and severe traumatic brain injury: results of the Austrian Neurosurvey study. Wien Klin Wochenschr. 2016;128(17–18):649–57.CrossRefPubMed Herzer G, Illievich U, Voelckel WG, Trimmel H. Current practice in neurocritical care of patients with subarachnoid haemorrhage and severe traumatic brain injury: results of the Austrian Neurosurvey study. Wien Klin Wochenschr. 2016;128(17–18):649–57.CrossRefPubMed
39.
Zurück zum Zitat Rusnak M, Janciak I, Majdan M, Wilbacher I, Mauritz W. Severe traumatic brain injury in Austria I: introduction to the study. Wien Klin Wochenschr. 2007;119(1–2):23–8.CrossRefPubMed Rusnak M, Janciak I, Majdan M, Wilbacher I, Mauritz W. Severe traumatic brain injury in Austria I: introduction to the study. Wien Klin Wochenschr. 2007;119(1–2):23–8.CrossRefPubMed
40.
Zurück zum Zitat Rosso A, Brazinova A, Janciak I, Wilbacher I, Rusnak M, Mauritz W. Severe traumatic brain injury in Austria II: epidemiology of hospital admissions. Wien Klin Wochenschr. 2007;119(1–2):29–34.CrossRefPubMed Rosso A, Brazinova A, Janciak I, Wilbacher I, Rusnak M, Mauritz W. Severe traumatic brain injury in Austria II: epidemiology of hospital admissions. Wien Klin Wochenschr. 2007;119(1–2):29–34.CrossRefPubMed
41.
Zurück zum Zitat Lenartova L, Janciak I, Wilbacher I, Rusnak M, Mauritz W. Severe traumatic brain injury in Austria III: prehospital status and treatment. Wien Klin Wochenschr. 2007;119(1–2):35–45.CrossRefPubMed Lenartova L, Janciak I, Wilbacher I, Rusnak M, Mauritz W. Severe traumatic brain injury in Austria III: prehospital status and treatment. Wien Klin Wochenschr. 2007;119(1–2):35–45.CrossRefPubMed
42.
Zurück zum Zitat Mauritz W, Janciak I, Wilbacher I, Rusnak M. Severe traumatic brain injury in Austria IV: intensive care management. Wien Klin Wochenschr. 2007;119(1–2):46–55.CrossRefPubMed Mauritz W, Janciak I, Wilbacher I, Rusnak M. Severe traumatic brain injury in Austria IV: intensive care management. Wien Klin Wochenschr. 2007;119(1–2):46–55.CrossRefPubMed
43.
Zurück zum Zitat Leitgeb J, Erb K, Mauritz W, Janciak I, Wilbacher I, Rusnak M. Severe traumatic brain injury in Austria V: CT findings and surgical management. Wien Klin Wochenschr. 2007;119(1–2):56–63.CrossRefPubMed Leitgeb J, Erb K, Mauritz W, Janciak I, Wilbacher I, Rusnak M. Severe traumatic brain injury in Austria V: CT findings and surgical management. Wien Klin Wochenschr. 2007;119(1–2):56–63.CrossRefPubMed
44.
Zurück zum Zitat Rusnak M, Janciak I, Majdan M, Wilbacher I, Mauritz W. Severe traumatic brain injury in Austria VI: effects of guideline-based management. Wien Klin Wochenschr. 2007;119(1–2):64–71.CrossRefPubMed Rusnak M, Janciak I, Majdan M, Wilbacher I, Mauritz W. Severe traumatic brain injury in Austria VI: effects of guideline-based management. Wien Klin Wochenschr. 2007;119(1–2):64–71.CrossRefPubMed
45.
Zurück zum Zitat Adibhatla RM, Hatcher JF. Citicoline mechanisms and clinical efficacy in cerebral ischemia. J Neurosci Res. 2002;70(2):133–9.CrossRefPubMed Adibhatla RM, Hatcher JF. Citicoline mechanisms and clinical efficacy in cerebral ischemia. J Neurosci Res. 2002;70(2):133–9.CrossRefPubMed
46.
Zurück zum Zitat Bustamante A, Giralt D, Garcia-Bonilla L, Campos M, Rosell A, Montaner J. Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem. 2012;123(2):217–25.CrossRefPubMed Bustamante A, Giralt D, Garcia-Bonilla L, Campos M, Rosell A, Montaner J. Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem. 2012;123(2):217–25.CrossRefPubMed
47.
Zurück zum Zitat Tayebati SK, Amenta F. Choline-containing phospholipids: relevance to brain functional pathways. Clin Chem Lab Med. 2013;51(3):513–21.CrossRefPubMed Tayebati SK, Amenta F. Choline-containing phospholipids: relevance to brain functional pathways. Clin Chem Lab Med. 2013;51(3):513–21.CrossRefPubMed
48.
Zurück zum Zitat Lozano R. CDP-choline in the treatment of cranio-encephalic traumata. J Neurol Sci. 1991;103(Suppl):S43–S7.CrossRefPubMed Lozano R. CDP-choline in the treatment of cranio-encephalic traumata. J Neurol Sci. 1991;103(Suppl):S43–S7.CrossRefPubMed
49.
Zurück zum Zitat Leon-Carrion J, Dominguez-Roldan JM, Murillo-Cabezas F, del Rosario Dominguez-Morales M, Munoz-Sanchez MA. The role of citicholine in neuropsychological training after traumatic brain injury. NeuroRehabilitation. 2000;14(1):33–40.PubMed Leon-Carrion J, Dominguez-Roldan JM, Murillo-Cabezas F, del Rosario Dominguez-Morales M, Munoz-Sanchez MA. The role of citicholine in neuropsychological training after traumatic brain injury. NeuroRehabilitation. 2000;14(1):33–40.PubMed
50.
Zurück zum Zitat Levin HS. Treatment of postconcussional symptoms with CDP-choline. J Neurol Sci. 1991;103(Suppl):S39–S42.CrossRefPubMed Levin HS. Treatment of postconcussional symptoms with CDP-choline. J Neurol Sci. 1991;103(Suppl):S39–S42.CrossRefPubMed
51.
Zurück zum Zitat Secades JJ. Probably role of citicoline in stroke rehabilitation: review of the literature. Rev Neurol. 2012;54(3):173–9.PubMed Secades JJ. Probably role of citicoline in stroke rehabilitation: review of the literature. Rev Neurol. 2012;54(3):173–9.PubMed
52.
Zurück zum Zitat Secades JJ. Citicoline for the treatment of head injury: a systematic review and meta-analysis of controlled clinical trials. J Trauma Treat. 2014;4(1):4.CrossRef Secades JJ. Citicoline for the treatment of head injury: a systematic review and meta-analysis of controlled clinical trials. J Trauma Treat. 2014;4(1):4.CrossRef
53.
54.
Zurück zum Zitat Ruff RL, Riechers RG. Effective treatment of traumatic brain injury: learning from experience. JAMA. 2012;308(19):2032–3.CrossRefPubMed Ruff RL, Riechers RG. Effective treatment of traumatic brain injury: learning from experience. JAMA. 2012;308(19):2032–3.CrossRefPubMed
55.
Zurück zum Zitat Fresta M, Wehrli E, Puglisi G. Enhanced therapeutic effect of cytidine-5′-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model. Pharm Res. 1995;12(11):1769–74.CrossRefPubMed Fresta M, Wehrli E, Puglisi G. Enhanced therapeutic effect of cytidine-5′-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model. Pharm Res. 1995;12(11):1769–74.CrossRefPubMed
56.
Zurück zum Zitat Horn SD, Corrigan JD, Bogner J, Hammond FM, Seel RT, Smout RJ, et al. Traumatic brain injury-practice based evidence study: design and patients, centers, treatments, and outcomes. Arch Phys Med Rehabil. 2015;96(8 Suppl):S178–S196.e15.CrossRefPubMedPubMedCentral Horn SD, Corrigan JD, Bogner J, Hammond FM, Seel RT, Smout RJ, et al. Traumatic brain injury-practice based evidence study: design and patients, centers, treatments, and outcomes. Arch Phys Med Rehabil. 2015;96(8 Suppl):S178–S196.e15.CrossRefPubMedPubMedCentral
57.
Zurück zum Zitat Phillips JP, Devier DJ, Feeney DM. Rehabilitation pharmacology: bridging laboratory work to clinical application. J Head Trauma Rehabil. 2003;18(4):342–56.CrossRefPubMed Phillips JP, Devier DJ, Feeney DM. Rehabilitation pharmacology: bridging laboratory work to clinical application. J Head Trauma Rehabil. 2003;18(4):342–56.CrossRefPubMed
Metadaten
Titel
Citicoline in severe traumatic brain injury: indications for improved outcome
A retrospective matched pair analysis from 14 Austrian trauma centers
verfasst von
Helmut Trimmel
Marek Majdan
Andrea Wodak
Guenther Herzer
Daniel Csomor
Alexandra Brazinova
Publikationsdatum
27.07.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1240-9

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