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04.10.2017 | original article

Blood pressure profile is associated with microalbuminuria and retinopathy in hypertensive nondiabetic patients

verfasst von: Assoc. Prof. Dr. Berrin Karadag, MD, Assoc. Prof. Dr. Tolga Ozyigit, MD, Dr. Zeliha Serindag, MD, Dr. Aysegul Ilhan, MD, Assoc. Prof. Dr. Beste Ozben, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2018

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Summary

Background

Target organ damage is important for global cardiovascular risk assessment. The aim of this study was to explore the association between the blood pressure profile and end-organ damage in a hypertensive non-diabetic cohort.

Methods

A total of 560 consecutive hypertensive nondiabetic patients (mean age: 58.2 ± 13.3 years, 221 men) were included in the study. All patients underwent thorough physical examination including fundoscopic examination. First morning urine samples were obtained from each patient and measurement of the albumin-to-creatinine ratio in first morning urine collection samples was used for diagnosis of microalbuminuria. All patients underwent a 24-h ambulatory blood pressure monitoring and were grouped as dippers and non-dippers according to the presence or absence of >10% decrease in blood pressure during the night, respectively.

Results

The non-dipper group consisted of 247 patients with a non-dipper blood pressure profile, 31 patients with reverse dipping and 4 patients with extreme dipping. Non-dipper patients were significantly older. Coronary artery disease, cerebrovascular disease, hypertensive retinopathy and microalbuminuria were significantly more prevalent in the non-dipper patients. Non-dipping hypertension increased the risk of hypertensive retinopathy by 1.89 times (95% confidence interval, CI:1.35–2.65, p < 0.001) and the risk of microalbuminuria by 2.23 times (95% CI:1.49–3.33, p < 0.001). Non-dipping hypertension was still significantly associated with hypertensive retinopathy and microalbuminuria when adjusted by age and sex.

Conclusion

Non-dipping hypertension was associated with increased risk of hypertensive retinopathy and microalbuminuria. Blood pressure profiles should also be considered in assessing the risk for hypertensive patients.

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Titel: Blood pressure profile is associated with microalbuminuria and retinopathy in hypertensive nondiabetic patients
verfasst von: Assoc. Prof. Dr. Berrin Karadag, MD
Assoc. Prof. Dr. Tolga Ozyigit, MD
Dr. Zeliha Serindag, MD
Dr. Aysegul Ilhan, MD
Assoc. Prof. Dr. Beste Ozben, MD
Publikationsdatum: 04.10.2017
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 5-6/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-017-1270-3

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusion

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