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Gastroenterologie 24. Juni 2016

Esophageal squamous papillomatosis

Dear editor,

Squamous papillomas of the esophagus are epithelial tumors considered to be benign. They are rare, occurring in 0.01 % of individuals at autopsy and 0.07 % of individuals in an endoscopy series. Development of extensive esophageal squamous papillomas, otherwise known as squamous papillomatosis of the esophagus (ESP) is even less common. We herein report a case with esophageal squamous papillomatosis.


A 39 year-old woman was admitted to hospital because of pyrosis and regurgitation. Her complaints started 4 days before hospitalization. She had no systemic disease on admission. She had no history of cigarette smoking and alcohol consumption. Her physical examination and laboratory test results were unremarkable. She had a history of ESP for 4 years. She had dyspeptic symptoms, unresponsive to proton pump inhibitor treatment prior to the diagnosis of ESP. She had no previous follow-up. Esophagoscopy revealed multiple verrucous lesions ranging between 2–12 mm, which was consistent with papillomatosis. Multiple biopsies were taken. The diagnosis of ESP was made. All tissue samples were negative for Human Papilloma Virus (HPV)-DNA and carcinoma. Due to the extensive lesions, no endoscopic and surgical treatment was performed. After 6 months, although lesions remained same as previous endoscopic findings, new lesions appeared on the posterior surface of the epiglottis. New biopsies were taken and no dysplasia or carcinoma were observed in histological specimens.

Assistant Prof. Şehmus Ölmez, Assoc. Prof. Mehmet Aslan, Assoc. Prof. Hüseyin Güdücüoğlu, Specialist Remzi Erten, Assoc. Prof. Adnan Taş, Specialist Bünyamin Sarıtaş, Wiener klinische Wochenschrift 11/12/2016

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