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memo - Magazine of European Medical Oncology

Erschienen in:

23.05.2018 | short review

ASH 2017: highlights in chronic myeloid leukemia

verfasst von: Klaus Geissler

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2018

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Summary

Despite remarkable achievements in the management of chronic myeloid leukemia (CML), there remain a number of challenges in the field. At the American Society of Hematology (ASH) Meeting 2017 several presentations addressed current problems around the topics CML stem cells, progression of CML into blast crisis (BC), and personalized treatment.

Vorheriger Artikel Update of clinical highlights presented at the 2017 American Society of Hematology Meeting

Nächster Artikel Acute myeloid leukemia—current data from the 2017 American Society of Hematology meeting

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Branford S, Wang P, Yeung D, et al. Integrative genomics reveals cancer associated mutations are common at diagnosis of CML in patients with poor response to TKI therapy. Blood. 2017;130(suppl1):abstr251.

Awad AS, Kankainen M, Eldfors S, et al. Identification of progression-associated mutations in Chronic Myeloid Leukemia (CML) by comparative genomic analysis. Blood. 2017;130(suppl1):abstr250.

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Mancini M, De Santis S, Monaldi C, et al. SETD2 loss of function is a recurrent event in advanced-phase chronic myeloid leukemia. Blood. 2017;130(suppl1):abstr43.

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Magistroni V, Piazza R, Mauri M, et al. De novo UBE2A mutations are recurrently acquired during CML progression and interfere with myeloid differentiation pathways. Blood. 2017;130(suppl1):abstr44.

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Hehlmann R, Lauseker M, Saussele S, et al. Final evaluation of randomized CML-study IV: 10-year survival and evolution of terminal phase. Blood. 2017;130(suppl1):abstr897.

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Cortes JE, Gambacorti-Passerini C, Deininger MW, et al. Bosutinib versus imatinib for newly diagnosed Chronic Myeloid Leukemia: 12-month patient-reported outcomes from the BFORE trial. Blood. 2017;130(suppl1):abstr2895.

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Turkina AG, Shukhov O, Chelysheva E, et al. PF-114 mesylate, a novel third generation ATP-competitive BCR-ABL tyrosine kinase inhibitor: first safety and efficacy data from a phase I study in patients with CML with failure of prior TKI therapy. Blood. 2017;130(suppl1):abstr895.

16.

Saussele S, Richter J, Guilhot J, et al. “Duration of Deep Molecular Response” Has Most Impact on the Success of Cessation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukemia—Results from the EURO-SKI Trial. Blood. 2017;130(suppl1):abstr313.

Titel: ASH 2017: highlights in chronic myeloid leukemia
verfasst von: Klaus Geissler
Publikationsdatum: 23.05.2018
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 2/2018
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-018-0406-0

Springer Medizin Österreich

Summary

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