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Embryologie und Teratologie

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Die Geburtshilfe

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Zusammenfassung

Die intrauterine menschliche Entwicklung durchläuft Stadien unterschiedlicher Empfindlichkeit gegenüber äußeren Einflüssen. Während sich die Reaktion auf exogene Noxen in den ersten beiden Wochen nach Konzeption weitgehend auf die Alternativen „vollständige Regeneration“ oder „Abort“ („Alles-oderNichts-Gesetz“) beschränkt, können Einflüsse in Woche 3–8 nach Konzeption zu Störungen der Organogenese und damit zu schweren morphologischen und funktionellen angeborenen Anomalien führen.

Schädigende äußere Einflüsse in der Fetalperiode ab Entwicklungswoche 9 resultieren eher in Wachstums- und Funktionsstörungen.

Nach der Thalidomid-Katastrophe zwischen 1958 und 1961 mit ca. 10.000 betroffenen Kindern (u. a. mit oft schweren Gliedmaßendefekten), gibt es bei der pharmazeutischen Industrie, Ärzten und Patientinnen Vorbehalte gegenüber dem Einsatz von Arzneimitteln in der Schwangerschaft. Ein therapeutischer Nihilismus bei chronisch kranken Schwangeren kann jedoch sowohl zu einer dramatischen Verschlechterung der Grunderkrankung der Schwangeren als auch zu einer erheblichen direkten und indirekten Gefährdung der fetalen Entwicklung führen.

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Authors and Affiliations

  1. Beratungssstelle für Reproduktionstoxikologie, Universitätsfrauenklinik Ulm, Ulm, Deutschland

    Wolfgang E. Paulus

  2. Lehrstuhl für Zellbiologie, Histologie und Embryologie, Medizinische Universität Graz, Graz, Österreich

    Herbert Juch

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  1. Wolfgang E. Paulus
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  2. Herbert Juch
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Correspondence to Wolfgang E. Paulus .

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Editors and Affiliations

  1. Frauenklinik, Medizinische Hochschule Hannover, Hannover, Niedersachsen, Deutschland

    Constantin von Kaisenberg

  2. Klinische Abteilung für Geburtshilfe, Medizinische Universität Graz, Graz, Steiermark, Österreich

    Philipp Klaritsch

  3. Geburtshilfe, Universitätsspital Basel, Basel Universitätsspital, Basel Stadt, Schweiz

    Irene Hösli-Krais

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Paulus, W.E., Juch, H. (2024). Embryologie und Teratologie. In: von Kaisenberg, C., Klaritsch, P., Hösli-Krais, I. (eds) Die Geburtshilfe. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44369-9_6-2

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  • DOI: https://doi.org/10.1007/978-3-662-44369-9_6-2

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Chapter history

  1. Latest

    Embryologie und Teratologie
    Published:
    15 February 2024

    DOI: https://doi.org/10.1007/978-3-662-44369-9_6-2

  2. Original

    Embryologie und Teratologie
    Published:
    18 March 2015

    DOI: https://doi.org/10.1007/978-3-662-44369-9_6-1

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