Zusammenfassung
Hypertensive Erkrankungen (HES) gehören zu den häufigsten Komplikationen in der Schwangerschaft. Auch in den industrialisierten Ländern bleibt die Präeklampsie eine der wichtigsten Ursachen für die maternale Mortalität.
Die Definition der Präeklampsie wurde hinsichtlich ihrer Pathophysiologie von vielen Gesellschaften verfeinert. Es gilt, zwischen früher und später Manifestation sowie plazentarer und maternaler Genese zu unterscheiden.
Der Fortschritt in der Forschung bezüglich angiogener Faktoren hat in einigen Leitlinien zu adaptierten Empfehlungen zum Screening im 1. Trimenon sowie der Diagnose und Kurzzeitprädiktion der Präeklampsie geführt. Die Kombination von Angiogenesefaktoren zusammen mit anamnestisch bestehenden Risikofaktoren, der Dopplersonografie der Aa. uterinae und dem mittleren arteriellen Blutdruck hat die Risikostratifizierung wesentlich verbessert (siehe Abschn. 6).
Nach wie vor ist die einzige kausale Therapie der Präeklampsie die Entbindung. Modernes Management berücksichtigt von der Früherkennung mit der Erfassung von Risikofaktoren über ein individualisiertes Betreuungskonzept in der Schwangerschaft und einer zeitgerechten Entbindung auch die postnatale Versorgung, insbesondere die Beratung bezüglich Langzeitkomplikationen für Mutter und Kind.
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Literatur
Abalos E, Cuesta C, Grosso AL, Chou D, Say L (2013) Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1–7
Abalos E, Duley L, Steyn DW (2014) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 2:CD002252
Abalos E, Duley L, Steyn DW, Gialdini C (2018) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 10:CD002252
Abildgaard U, Heimdal K (2013) Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol 166(2):117–123
Adams DH, Clark RA, Davies MJ, de Lacey S (2016) A meta-analysis of neonatal health outcomes from oocyte donation. J Dev Orig Health Dis 7(3):257–272
Ahmed A, Williams DJ, Cheed V, Middleton LJ, Ahmad S, Wang K, Vince AT, Hewett P, Spencer K, Khan KS, Daniels JP, Stam PTCG (2020) Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial. BJOG 127(4):478–488
Akolekar R, Bower S, Flack N, Bilardo CM, Nicolaides KH (2011) Prediction of miscarriage and stillbirth at 11–13 weeks and the contribution of chorionic villus sampling. Prenat Diagn 31(1):38–45
Akolekar R, Syngelaki A, Poon L, Wright D, Nicolaides KH (2013) Competing risks model in early screening for preeclampsia by biophysical and biochemical markers. Fetal Diagn Ther 33(1):8–15
Allen AM, Kim WR, Larson JJ, Rosedahl JK, Yawn BP, McKeon K, Hay JE (2016) The epidemiology of liver diseases unique to pregnancy in a US community: a population-based study. Clin Gastroenterol Hepatol 14(2):287–294. e281–282
Allotey J, Marlin N, Mol BW, Von Dadelszen P, Ganzevoort W, Akkermans J, Ahmed A, Daniels J, Deeks J, Ismail K, Barnard AM, Dodds J, Kerry S, Moons C, Khan KS, Riley RD, Thangaratinam S (2017) Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study. Diagn Progn Res 1:6
Alsnes IV, Vatten LJ, Fraser A, Bjorngaard JH, Rich-Edwards J, Romundstad PR, Asvold BO (2017) Hypertension in pregnancy and offspring cardiovascular risk in young adulthood: prospective and sibling studies in the HUNT Study (Nord-Trondelag Health Study) in Norway. Hypertension 69(4):591–598
Altinkaya SO, Nergiz S, Kucuk M, Yuksel H, Dayanir Y (2014) Posterior reversible encephalopathy syndrome in obstetric patients. Report of three cases with literature review. Clin Exp Obstet Gynecol 41(6):730–733
Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, Smith D, Group MTC (2002) Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 359(9321):1877–1890
Altmann J, Kummer J, Herse F, Hellmeyer L, Schlembach D, Henrich W, Weichert A (2022) Lifting the veil of secrecy: maternal and neonatal outcome of oocyte donation pregnancies in Germany. Arch Gynecol Obstet 306(1):59–69
American College of Obstetricians and Gynecologists Committee on Practice Bulletins (2019) ACOG practice bulletin no. 203: chronic hypertension in pregnancy. Obstet Gynecol 133(1):e26–e50
American College of Obstetricians and Gynecologists Committee on Practice Bulletins (2020) Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. Obstet Gynecol 135(6):e237–e260
Amro FH, Moussa HN, Ashimi OA, Sibai BM (2016) Treatment options for hypertension in pregnancy and puerperium. Expert Opin Drug Saf 15(12):1635–1642
Ananth CV, Duzyj CM, Yadava S, Schwebel M, Tita ATN, Joseph KS (2019) Changes in the prevalence of chronic hypertension in pregnancy, United States, 1970 to 2010. Hypertension 74(5):1089–1095
Anderson GD, Carr DB (2009) Effect of pregnancy on the pharmacokinetics of antihypertensive drugs. Clin Pharmacokinet 48(3):159–168
Ankichetty SP, Chin KJ, Chan VW, Sahajanandan R, Tan H, Grewal A, Perlas A (2013) Regional anesthesia in patients with pregnancy induced hypertension. J Anaesthesiol Clin Pharmacol 29(4):435–444
Ankumah NE, Sibai BM (2017) Chronic hypertension in pregnancy: diagnosis, management, and outcomes. Clin Obstet Gynecol 60(1):206–214
Aracki-Trenkić A, Stojanov D, Trenkić M, Radovanović Z, Ignjatović J, Ristić S, Trenkić-Bozinović M (2016) Atypical presentation of posterior reversible encephalopathy syndrome: clinical and radiological characteristics in eclamptic patients. Bosn J Basic Med Sci 16(3):180–186
Association of Ontario Midwives (2023) Hypertensive Disorders of Pregnancy. (Clinical Practice Guideline No. 15). https://www.ontariomidwives.ca/sites/default/files/2023-05/CPG-HDP-2023-PUB.pdf. Zugegriffen am 13.07.2023
Audibert F, Friedman SA, Frangieh AY, Sibai BM (1996) Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 175(2):460–464
Audibert F, Boucoiran I, An N, Aleksandrov N, Delvin E, Bujold E, Rey E (2010) Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women. Am J Obstet Gynecol 203(4):383. e381–388.
Aya AG, Ondze B, Ripart J, Cuvillon P (2016) Seizures in the peripartum period: epidemiology, diagnosis and management. Anaesth Crit Care Pain Med 35(Suppl 1):S13–S21
Ayala DE, Ucieda R, Hermida RC (2013) Chronotherapy with low-dose aspirin for prevention of complications in pregnancy. Chronobiol Int 30(1–2):260–279
Bahado-Singh RO, Jodicke C (2010) Uterine artery Doppler in first-trimester pregnancy screening. Clin Obstet Gynecol 53(4):879–887
Ballantyne JW (1892) The diseases and deformities of the foetus: an attempt towards a system of antenatal pathology. Oliver and Boyd, Edinburgh
Barton JR, Sibai BM (1992) Acute life-threatening emergencies in preeclampsia – eclampsia. Clin Obstet Gynecol 35(2):402–413
Barton JR, Sibai BM (2008) Prediction and prevention of recurrent preeclampsia. Obstet Gynecol 112(2 Pt 1):359–372
Barton JR, O’Brien JM, Bergauer NK, Jacques DL, Sibai BM (2001) Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol 184(5):979–983
Bartynski WS (2008) Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. AJNR Am J Neuroradiol 29(6):1036–1042
Bastos MH, Furuta M, Small R, McKenzie-Mcharg K, Bick D (2015) Debriefing interventions for the prevention of psychological trauma in women following childbirth. Cochrane Database Syst Rev 4:CD007194
Bauchat J, Weiniger C, Sultan P, Habib A, Ando K, Kowalczyk J, Kato R, George R, Palmer C, Carvalho B (2019) Society for Obstetric Anesthesia and Perinatology consensus statement: monitoring recommendations for prevention and detection of respiratory depression associated with administration of neuraxial morphine for cesarean delivery analgesia. Anesth Analg 129(2):458–474
Bauer ST, Cleary KL (2009) Cardiopulmonary complications of pre-eclampsia. Semin Perinatol 33(3):158–165
Bello N, Rendon ISH, Arany Z (2013) The relationship between pre-eclampsia and peripartum cardiomyopathy: a systematic review and meta-analysis. J Am Coll Cardiol 62:1715–1723
Bello NA, Miller E, Cleary K, Wapner R, Shimbo D, Tita AT (2018) Out of office blood pressure measurement in pregnancy and the postpartum period. Curr Hypertens Rep 20(12):101
Bello NA, Zhou H, Cheetham TC, Miller E, Getahun DT, Fassett MJ, Reynolds K (2021) Prevalence of hypertension among pregnant women when using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines and Association With Maternal and Fetal Outcomes. JAMA Netw Open 4(3):e213808
Bellos I, Pergialiotis V, Papapanagiotou A, Loutradis D, Daskalakis G (2020) Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. Am J Obstet Gynecol 223(4):525–537
Benedetti TJ, Kates R, Williams V (1985) Hemodynamic observations in severe preeclampsia complicated by pulmonary edema. Am J Obstet Gynecol 152(3):330–334
Benko Z, Chaveeva P, de Paco Matallana C, Zingler E, Wright A, Wright D, Nicolaides KH (2019a) Validation of competing-risks model in screening for pre-eclampsia in twin pregnancy by maternal factors. Ultrasound Obstet Gynecol 53(5):649–654
Benko Z, Chaveeva P, de Paco Matallana C, Zingler E, Wright D, Nicolaides KH (2019b) Revised competing-risks model in screening for pre-eclampsia in twin pregnancy by maternal characteristics and medical history. Ultrasound Obstet Gynecol 54(5):617–624
Benko Z, Wright A, Rehal A, Cimpoca B, Syngelaki A, Delgado JL, Tsokaki T, de Alvarado M, Vojtassakova D, Malligiannis Ntalianis K, Chaveeva P, Del Campo A, de Ganzo T, Resta C, Atanasova V, Accurti V, Villalain C, Aguilera J, Dojcinovska D, O’Gorman N, Plasencia W, Zingler E, Dutemeyer V, Alvar B, Casanova MC, Nicolaides KH (2021) Prediction of pre-eclampsia in twin pregnancy by maternal factors and biomarkers at 11–13 weeks’ gestation: data from EVENTS trial. Ultrasound Obstet Gynecol 57(2):257–265
Bereczki D Jr, Szegedi N, Szakacs Z, Gubucz I, May Z (2016) Cryptogenic postpartum stroke. Neurol Neurochir Pol 50(5):370–373
Bergink V, Laursen TM, Johannsen BM, Kushner SA, Meltzer-Brody S, Munk-Olsen T (2015) Pre-eclampsia and first-onset postpartum psychiatric episodes: a Danish population-based cohort study. Psychol Med 45(16):3481–3489
Berhan Y, Berhan A (2015) Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. J Obstet Gynaecol Res 41(6):831–842
Bonifacino E, Schwartz EB, Jun H, Wessel CB, Corbelli JA (2018) Effect of lactation on maternal hypertension: a systematic review. Breastfeed Med 13(9):578–588
Booker WA, Gyamfi-Bannerman C, Sheen JJ, Wright JD, Siddiq Z, D’Alton ME, Friedman AM (2018) Maternal outcomes by race for women aged 40 years or older. Obstet Gynecol 132(2):404–413
Bouter AR, Duvekot JJ (2020) Evaluation of the clinical impact of the revised ISSHP and ACOG definitions on preeclampsia. Pregnancy Hypertens 19:206–211
Brady CW (2020) Liver disease in pregnancy: what’s new. Hepatol Commun 4(2):145–156
Bramham K, Nelson-Piercy C, Brown MJ, Chappell LC (2013) Postpartum management of hypertension. BMJ 346(f894):f894
Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC (2014) Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ 348:g2301
Broekhuijsen K, Van Baaren G-J, Van Pampus MG, Ganzevoort W, Sikkema JM, Woiski MD, Oudijk MA, Bloemenkamp KWM, Scheepers HCJ, Bremer HA, Rijnders RJP, Van Loon AJ, Perquin DAM, Sporken JMJ, Papatsonis DNM, Van Huizen ME, Vredevoogd CB, Brons JTJ, Kaplan M, Van Kaam AH, Groen H, Porath MM, Van den Berg PP, Mol BWJ, Franssen MTM, Langenveld J (2015) Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial. Lancet 385(9986):2492–2501
Brown MA, Mangos G, Davis G, Homer C (2005) The natural history of white coat hypertension during pregnancy. BJOG 112(5):601–606
Brown MA, Mackenzie C, Dunsmuir W, Roberts L, Ikin K, Matthews J, Mangos G, Davis G (2007) Can we predict recurrence of pre-eclampsia or gestational hypertension? BJOG 114(8):984–993
Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, Hall DR, Warren CE, Adoyi G, Ishaku S, International Society for the Study of Hypertension In, P (2018) Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension 72(1):24–43
Brown MA, Roberts L, Hoffman A, Henry A, Mangos G, O’Sullivan A, Pettit F, Youssef G, Xu L, Davis GK (2020) Recognizing cardiovascular risk after preeclampsia: the P4 study. J Am Heart Assoc 9(22):e018604
Brown MC, Best KE, Pearce MS, Waugh J, Robson SC, Bell R (2013) Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur J Epidemiol 28(1):1–19
Browning MF, Levy HL, Wilkins-Haug LE, Larson C, Shih VE (2006) Fetal fatty acid oxidation defects and maternal liver disease in pregnancy. Obstet Gynecol 107(1):115–120
Buchbinder A, Sibai BM, Caritis S, Macpherson C, Hauth J, Lindheimer MD, Klebanoff M, Vandorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G, National Institute of Child, H, Human Development Network of Maternal-Fetal Medicine, U (2002) Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol 186(1):66–71
Bujold E, Morency AM, Roberge S, Lacasse Y, Forest JC, Giguere Y (2009) Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis. J Obstet Gynaecol Can 31(9):818–826
Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, Forest JC, Giguere Y (2010) Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol 116(2 Pt 1):402–414
Bujold E, Roberge S, Nicolaides KH (2014) Low-dose aspirin for prevention of adverse outcomes related to abnormal placentation. Prenat Diagn 34(7):642–648
Campbell DM, Macgillivray I, Carr-Hill R (1985) Pre-eclampsia in second pregnancy. Br J Obstet Gynaecol 92(2):131–140
Carpentier C, Guerby P, Camire B, Tapp S, Boutin A, Bujold E (2022) Aspirin responsiveness at a dose of 80 mg and its impact on birth weight when used in twin pregnancies: the GAP pilot randomized trial. Am J Perinatol 39(13):1396–1400
Castleman JS, Ganapathy R, Taki F, Lip GY, Steeds RP, Kotecha D (2016) Echocardiographic structure and function in hypertensive disorders of pregnancy: a systematic review. Circ Cardiovasc Imaging 9(9):e004888
Cerdeira AS, O’Sullivan J, Ohuma EO, Harrington D, Szafranski P, Black R, Mackillop L, Impey L, Greenwood C, James T, Smith I, Papageorghiou AT, Knight M, Vatish M (2019) Randomized interventional study on prediction of preeclampsia/eclampsia in women with suspected preeclampsia: INSPIRE. Hypertension 74(4):983–990
Ch’ng CL, Morgan M, Hainsworth I, Kingham JG (2002) Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut 51(6):876–880
Chaemsaithong P, Sahota DS, Poon LC (2022) First trimester preeclampsia screening and prediction. Am J Obstet Gynecol 226(2S):S1071–S1097. e1072
Chappell LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny LC, Redman CW, Shennan AH (2013) Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation 128(19):2121–2131
Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG, Group PS (2019a) Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet 394(10201):849–860
Chappell LC, Brocklehurst P, Green ME, Hunter R, Hardy P, Juszczak E, Linsell L, Chiocchia V, Greenland M, Placzek A, Townend J, Marlow N, Sandall J, Shennan A, Group PS (2019b) Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet 394(10204):1181–1190
Charles C, Gafni A, Whelan T (1997) Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango). Soc Sci Med 44(5):681–692
Chen BA, Parviainen K, Jeyabalan A (2008) Correlation of catheterized and clean catch urine protein/creatinine ratios in preeclampsia evaluation. Obstet Gynecol 112(3):606–610
Cheng YKY, Poon LCY, Shennan A, Leung TY, Sahota DS (2019) Inter-manufacturer comparison of automated immunoassays for the measurement of soluble FMS-like tyrosine kinase-1 and placental growth factor. Pregnancy Hypertens 17:165–171
Churchill D, Beevers GD, Meher S, Rhodes C (2007) Diuretics for preventing pre-eclampsia. Cochrane Database Syst Rev 1:CD004451
Cines DB, Levine LD (2017) Thrombocytopenia in pregnancy. Blood 130(21):2271–2277
Cleary KL, Siddiq Z, Ananth CV, Wright JD, Too G, D’Alton ME, Friedman AM (2018) Use of antihypertensive medications during delivery hospitalizations complicated by preeclampsia. Obstet Gynecol 131(3):441–450
Cnossen JS, Morris RK, Ter Riet G, Mol BW, Van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178(6):701–711
Cnossen JS, Ter Riet G, Mol BW, Van der Post JA, Leeflang MM, Meads CA, Hyde C, Khan KS (2009) Are tests for predicting pre-eclampsia good enough to make screening viable? A review of reviews and critical appraisal. Acta Obstet Gynecol Scand 88(7):758–765
Coetzee EJ, Dommisse J, Anthony J (1998) A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia. Br J Obstet Gynaecol 105(3):300–303
Conde-Agudelo A, Villar J, Lindheimer M (2004) World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol 104(6):1367–1391
Cote AM, Brown MA, Lam E, Von Dadelszen P, Firoz T, Liston RM, Magee LA (2008) Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review. BMJ 336(7651):1003–1006
Cozzolino M, Bianchi C, Mariani G, Marchi L, Fambrini M, Mecacci F (2015) Therapy and differential diagnosis of posterior reversible encephalopathy syndrome (PRES) during pregnancy and postpartum. Arch Gynecol Obstet 292(6):1217–1223
Creanga AA, Berg CJ, Syverson C, Seed K, Bruce FC, Callaghan WM (2015) Pregnancy-related mortality in the United States, 2006–2010. Obstet Gynecol 125(1):5–12
Crispi F, Hernandez-Andrade E, Pelsers MM, Plasencia W, Benavides-Serralde JA, Eixarch E, Le Noble F, Ahmed A, Glatz JF, Nicolaides KH, Gratacos E (2008) Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol 199(3):254. e251–258
Crispi F, Miranda J, Gratacos E (2018) Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease. Am J Obstet Gynecol 218(2S):S869–S879
Crovetto F, Somigliana E, Peguero A, Figueras F (2013) Stroke during pregnancy and pre-eclampsia. Curr Opin Obstet Gynecol 25(6):425–432
Cruz MO, Gao W, Hibbard JU (2012) What is the optimal time for delivery in women with gestational hypertension? Am J Obstet Gynecol 207(3):214. e211–216
Cruz-Lemini M, Vazquez JC, Ullmo J, Llurba E (2022) Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis. Am J Obstet Gynecol 226(2S):S1126–S1144. e1117
Cuckle H (2004) Principles of screening. Obstet Gynecol 6(1):21–25
Cuckle H (2020) Strategies for prescribing aspirin to prevent preeclampsia: a cost-effectiveness analysis. Obstet Gynecol 135(1):217
Cuero MR, Varelas PN (2016) Neurologic complications in pregnancy. Crit Care Clin 32(1):43–59
Dadelszen P von, Magee LA (2002) Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: an updated metaregression analysis. J Obstet Gynaecol Can 24(12):941–945
Dadelszen P von, Ornstein MP, Bull SB, Logan AG, Koren G Magee LA (2000) Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet 355(9198):87–92
Dadelszen P von, Payne B, Li J, Ansermino JM, Broughton Pipkin F, Cote AM, Douglas MJ, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, WalleyKR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA, Group PS (2011) Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet 377(9761):219–227
Danielli M, Gillies C, Thomas RC, Melford SE, Baker PN, Yates T, Khunti K, Tan BK (2022) Effects of supervised exercise on the development of hypertensive disorders of pregnancy: a systematic review and meta-analysis. J Clin Med 11(3):793
Dathan-Stumpf A, Lia M (2022) Pharmakotherapie. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 175–184
Dathan-Stumpf A, Stepan H (2022) Differentialdiagnosen. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 145–164
De Schepper S, Vercauteren T, Tersago J, Jacquemyn Y, Raes F, Franck E (2016) Post-Traumatic Stress Disorder after childbirth and the influence of maternity team care during labour and birth: a cohort study. Midwifery 32:87–92
De Vries JI, Van Pampus MG, Hague WM, Bezemer PD, Joosten JH, Investigators F (2012) Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. J Thromb Haemost 10(1):64–72
Dennis AT (2012) Management of pre-eclampsia: issues for anaesthetists. Anaesthesia 67(9):1009–1020
Deruelle P, Coudoux E, Ego A, Houfflin-Debarge V, Codaccioni X, Subtil D (2006) Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome. A study in 453 consecutive pregnancies. Eur J Obstet Gynecol Reprod Biol 125(1):59–65
Desai DK, Moodley J, Naidoo DP, Bhorat I (1996) Cardiac abnormalities in pulmonary oedema associated with hypertensive crises in pregnancy. Br J Obstet Gynaecol 103(6):523–528
Dipietro L, Evenson KR, Bloodgood B, Sprow K, Troiano RP, Piercy KL, Vaux-Bjerke A, Powell KE, Physical Activity Guidelines Advisory, C (2019) Benefits of physical activity during pregnancy and postpartum: an umbrella review. Med Sci Sports Exerc 51(6):1292–1302
Dixon PH, Williamson C (2016) The pathophysiology of intrahepatic cholestasis of pregnancy. Clin Res Hepatol Gastroenterol 40(2):141–153
Dougall G, Franssen M, Tucker KL, Yu LM, Hinton L, Rivero-Arias O, Abel L, Allen J, Band RJ, Chisholm A, Crawford C, Green M, Greenfield S, Hodgkinson J, Leeson P, McCourt C, Mackillop L, Nickless A, Sandall J, Santos M, Tarassenko L, Velardo C, Wilson H, Yardley L, Chappell L, McManus RJ (2020) Blood pressure monitoring in high-risk pregnancy to improve the detection and monitoring of hypertension (the BUMP 1 and 2 trials): protocol for two linked randomised controlled trials. BMJ Open 10(1):e034593
Douglas KA, Redman CW (1994) Eclampsia in the United Kingdom. BMJ 309(6966):1395–1400
Droege LA, Verlohren S (2022) Prädiktion. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 127–144
Droege LA, Perschel FH, Stutz N, Gafron A, Frank L, Busjahn A, Henrich W, Verlohren S (2021) Prediction of preeclampsia-related adverse outcomes with the sFlt-1 (soluble fms-Like Tyrosine Kinase 1)/PlGF (placental growth factor)-ratio in the clinical routine: a real-world study. Hypertension 77(2):461–471
Duhig KE, Myers J, Seed PT, Sparkes J, Lowe J, Hunter RM, Shennan AH, Chappell LC, Group PT (2019) Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial. Lancet 393(10183):1807–1818
Duley L (2011) Pre-eclampsia, eclampsia, and hypertension. BMJ Clin Evid 2011:1402
Duley L, Henderson-Smart D, Meher S (2005) Altered dietary salt for preventing pre-eclampsia, and its complications. Cochrane Database Syst Rev 4:CD005548
Duley L, Gulmezoglu AM, Chou D (2010a) Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev 9:CD002960
Duley L, Gulmezoglu AM, Henderson-Smart DJ, Chou D (2010b) Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 11:CD000025
Duley L, Henderson-Smart DJ, Chou D (2010c) Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev 10:CD000128
Duley L, Henderson-Smart DJ, Walker GJ, Chou D (2010d) Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev 12:CD000127
Duley L, Meher S, Hunter KE, Seidler AL, Askie LM (2019) Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2019(10):CD004659
Duvekot JJ, Cheriex EC, Pieters FA, Menheere PP, Peeters LH (1993) Early pregnancy changes in hemodynamics and volume homeostasis are consecutive adjustments triggered by a primary fall in systemic vascular tone. Am J Obstet Gynecol 169(6):1382–1392
Eastabrook G, Brown M, Sargent I (2011) The origins and end-organ consequence of pre-eclampsia. Best Pract Res Clin Obstet Gynaecol 25(4):435–447
Easterling T, Mundle S, Bracken H, Parvekar S, Mool S, Magee LA, Von Dadelszen P, Shochet T, Winikoff B (2019) Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. Lancet 394(10203):1011–1021
Easterling TR (2016) Post-control of hypertension in pregnancy study (CHIPS): what is the optimal strategy to manage hypertension during pregnancy? Hypertension 68(1):36–38
Edlow AG, Edlow BL, Edlow JA (2016) Diagnosis of acute neurologic emergencies in pregnant and postpartum women. Emerg Med Clin North Am 34(4):943–965
Egerman RS, Witlin AG, Friedman SA, Sibai BM (1996) Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome in pregnancy: review of 11 cases. Am J Obstet Gynecol 175(4 Pt 1):950–956
Eleanor MFRD, Giorgione DV, Stevens MO, Thilaganathan PB (2022) Low-dose aspirin for the prevention of superimposed pre-eclampsia in women with chronic hypertension: a systematic review and meta-analysis. Am J Obstet Gynecol 228:395–408
European Society of Gynecology, Association for European Paediatric Cardiology, German Society for Gender Medicine, Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, Cifkova R, Ferreira R, Foidart JM, Gibbs JS, Gohlke-Baerwolf C, Gorenek B, Iung B, Kirby M, Maas AH, Morais J, Nihoyannopoulos P, Pieper PG, Presbitero P, Roos-Hesselink JW, Schaufelberger M, Seeland U, Torracca L, Guidelines, E. S. C. C. F. P (2011) ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 32(24):3147–3197
Euser AG, Metz TD, Allshouse AA, Heyborne KD (2016) Low-dose aspirin for pre-eclampsia prevention in twins with elevated human chorionic gonadotropin. J Perinatol 36(8):601–605
Faupel-Badger JM, Mcelrath TF, Lauria M, Houghton LC, Lim KH, Parry S, Cantonwine D, Lai G, Karumanchi SA, Hoover RN, Troisi R (2015) Maternal circulating angiogenic factors in twin and singleton pregnancies. Am J Obstet Gynecol 212(5):636. e631–638
Ferrari N, Graf C (2017) Körperliche Aktivität und Schwangerschaft. Frauenarzt 58(9):736–740
Filipecka-Tyczka D, Pokropek A, Kajdy A, Modzelewski J, Rabijewski M (2021) Uterine artery Doppler reference ranges in a twin caucasian population followed longitudinally from 17 to 37 weeks gestation compared to that of singletons. J Ultrasound Med 40(11):2421–2429
Fisher SJ (2015) Why is placentation abnormal in preeclampsia? Am J Obstet Gynecol 213(4 Suppl):S115–s122
Fitzpatrick KE, Hinshaw K, Kurinczuk JJ, Knight M (2014) Risk factors, management, and outcomes of hemolysis, elevated liver enzymes, and low platelets syndrome and elevated liver enzymes, low platelets syndrome. Obstet Gynecol 123(3):618–627
Fong A, Chau CT, Pan D, Ogunyemi DA (2013) Clinical morbidities, trends, and demographics of eclampsia: a population-based study. Am J Obstet Gynecol 209(3):229. e221–227
Ford ND, Cox S, Ko JY, Ouyang L, Romero L, Colarusso T, Ferre CD, Kroelinger CD, Hayes DK, Barfield WD (2022) Hypertensive disorders in pregnancy and mortality at delivery hospitalization – United States, 2017–2019. MMWR Morb Mortal Wkly Rep 71(17):585–591
Francisco C, Wright D, Benko Z, Syngelaki A, Nicolaides KH (2017a) Competing-risks model in screening for pre-eclampsia in twin pregnancy according to maternal factors and biomarkers at 11–13 weeks’ gestation. Ultrasound Obstet Gynecol 50(5):589–595
Francisco C, Wright D, Benko Z, Syngelaki A, Nicolaides KH (2017b) Competing-risks model in screening for pre-eclampsia in twin pregnancy by maternal characteristics and medical history. Ultrasound Obstet Gynecol 50(4):501–506
Francisco C, Gamito M, Reddy M, Rolnik DL (2022) Screening for preeclampsia in twin pregnancies. Best Pract Res Clin Obstet Gynaecol 84:55–65
Frontera JA, Ahmed W (2014) Neurocritical care complications of pregnancy and puerperum. J Crit Care 29(6):1069–1081
Gallo DM, Wright D, Casanova C, Campanero M, Nicolaides KH (2016) Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 19–24 weeks’ gestation. Am J Obstet Gynecol 214(5):619 e611–619 e617
Gangaram R, Ojwang PJ, Moodley J, Maharaj D (2005) The accuracy of urine dipsticks as a screening test for proteinuria in hypertensive disorders of pregnancy. Hypertens Pregnancy 24(2):117–123
Geipel A, Hennemann F, Fimmers R, Willruth A, Lato K, Gembruch U, Berg C (2011) Reference ranges for Doppler assessment of uterine artery resistance and pulsatility indices in dichorionic twin pregnancies. Ultrasound Obstet Gynecol 37(6):663–667
George JN, Nester CM, McIntosh JJ (2015) Syndromes of thrombotic microangiopathy associated with pregnancy. Hematology Am Soc Hematol Educ Program 2015:644–648
Goel A, Ramakrishna B, Zachariah U, Ramachandran J, Eapen CE, Kurian G, Chandy G (2011) How accurate are the Swansea criteria to diagnose acute fatty liver of pregnancy in predicting hepatic microvesicular steatosis? Gut 60(1):138–139; author reply 139–140
Goffin SM, Derraik JGB, Groom KM, Cutfield WS (2018) Maternal pre-eclampsia and long-term offspring health: Is there a shadow cast? Pregnancy Hypertens 12:11–15
Gofton EN, Capewell V, Natale R, Gratton RJ (2001) Obstetrical intervention rates and maternal and neonatal outcomes of women with gestational hypertension. Am J Obstet Gynecol 185(4):798–803
Gonzalez-Quintero VH, Luke B, O’Sullivan MJ, Misiunas R, Anderson E, Nugent C, Witter F, Mauldin J, Newman R, D’Alton M, Grainger D, Saade G, Hankins G, Macones G (2003) Antenatal factors associated with significant birth weight discordancy in twin gestations. Am J Obstet Gynecol 189(3):813–817
Gorgui J, Gorshkov M, Khan N, Daskalopoulou SS (2014) Hypertension as a risk factor for ischemic stroke in women. Can J Cardiol 30(7):774–782
Groeneveld E, Lambers MJ, Lambalk CB, Broeze KA, Haapsamo M, De Sutter P, Schoot BC, Schats R, Mol BW, Hompes PG (2013) Preconceptional low-dose aspirin for the prevention of hypertensive pregnancy complications and preterm delivery after IVF: a meta-analysis with individual patient data. Hum Reprod 28(6):1480–1488
Grotegut CA (2016) Prevention of preeclampsia. J Clin Invest 126(12):4396–4398
Guillen U, Suh S, Munson D, Posencheg M, Truitt E, Zupancic JA, Gafni A, Kirpalani H (2012) Development and pretesting of a decision-aid to use when counseling parents facing imminent extreme premature delivery. J Pediatr 160(3):382–387
Gupta M, Feinberg BB, Burwick RM (2018a) Thrombotic microangiopathies of pregnancy: differential diagnosis. Pregnancy Hypertens 12:29–34
Gupta M, Greene N, Kilpatrick SJ (2018b) Timely treatment of severe maternal hypertension and reduction in severe maternal morbidity. Pregnancy Hypertens 14:55–58
Hackenberg H, Rappe N, Wohlers S, Meyer-Wittkopf M, Schulz KD (1998) Wertigkeit des C-reaktiven Proteins (CRP) beim HELLP-Syndrom. Geburtshilfe Frauenheilkd 58(9):253–265
Hagenbeck C, Pecks U, Lammert F, Hutten MAC, Borgmeier F, Fehm T, Schleussner E, Maul H, Kehl S, Hamza A, Keitel V (2021) [Intrahepatic cholestasis of pregnancy]. Gynäkologe 54(5):341–356.
Haram K, Svendsen E, Abildgaard U (2009) The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth 9:8
Hassan S, Westwood JP, Ellis D, Laing C, Mc Guckin S, Benjamin S, Scully M (2015) The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry. Br J Haematol 171(5):830–835
Hauth J (2000) Pregnancy outcomes in healthy nulliparas who developed hypertension. Obstet Gynecol 95(1):24–28
Hayes-Ryan D, Hemming K, Breathnach F, Cotter A, Devane D, Hunter A, McAuliffe FM, Morrison JJ, Murphy DJ, Khashan A, McElroy B, Murphy A, Dempsey E, O’Donoghue K, Kenny LC (2019) PARROT Ireland: Placental growth factor in Assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a Stepped Wedge Cluster Randomised Control Trial Research Study Protocol. BMJ Open 9(2):e023562
Henry DE, Mcelrath TF, Smith NA (2013) Preterm severe preeclampsia in singleton and twin pregnancies. J Perinatol 33(2):94–97
Hermida RC, Ayala DE, Iglesias M, Mojon A, Silva I, Ucieda R, Fernandez JR (1997) Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women. Hypertension 30(3 Pt 2):589–595
Hermida RC, Ayala DE, Fernandez JR, Mojon A, Alonso I, Silva I, Ucieda R, Codesido J, Iglesias M (1999) Administration time-dependent effects of aspirin in women at differing risk for preeclampsia. Hypertension 34(4 Pt 2):1016–1023
Hermida RC, Ayala DE, Calvo C, Lopez JE (2005) Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J Am Coll Cardiol 46(6):975–983
Hermida RC, Ayala DE, Mojon A, Fernandez JR (2009) Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension. Am J Hypertens 22(8):896–903
Hernandez-Diaz S, Toh S, Cnattingius S (2009) Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ 338:b2255
Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334(8):494–500
Hjartardottir S, Leifsson BG, Geirsson RT, Steinthorsdottir V (2006) Recurrence of hypertensive disorder in second pregnancy. Am J Obstet Gynecol 194(4):916–920
Hofmeyr GJ, Lawrie TA, Atallah AN, Torloni MR (2018) Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 10:CD001059
Hofmeyr GJ, Betrán AP, Singata-Madliki M, Cormick G, Munjanja SP, Fawcus S, Mose S, Hall D, Ciganda A, Seuc AH, Lawrie TA, Bergel E, Roberts JM, Von Dadelszen P, Belizán JM, Althabe F, Belizán JM, Bergel E, Ciganda A, Cormick G, Sawchuck D, Vidler M, Allie S, Anthony J, Frank K, de Greeff A, Fawcus S, Hall D, Hofmeyr J, Kovane M, Kovane P, Lawrie T, Mose S, Mshweshwe N, Mqikela V, Njikelana P, Novikova N, Oyebajo A, Parker C, Phuti A, Singata-Madliki M, Van Papendorp E, Williams X, Betrán AP, Dannemann T, Seuc A, Magee L, Von Dadelszen P, Donnay F, Drebit S, Roberts J, Guzha B, Makaza E, Manyame S, Munjanja S, Tahuringana E (2019) Prepregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 393(10169):330–339
Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL (2011) Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26(10):2341–2357
Huang WY, Saver JL, Wu YL, Lin CJ, Lee M, Ovbiagele B (2019) Frequency of intracranial hemorrhage with low-dose aspirin in individuals without symptomatic cardiovascular disease: a systematic review and meta-analysis. JAMA Neurol 76(8):906–914
Huppertz B (2018) The critical role of abnormal trophoblast development in the etiology of preeclampsia. Curr Pharm Biotechnol 19(10):771–780
Huppertz B (2022) Ätiologie und Pathophysiologie: Plazenta. In: Holger S, Stefan V (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 37–60
Isler CM, Rinehart BK, Terrone DA, Martin RW, Magann EF, Martin JN Jr (1999) Maternal mortality associated with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 181(4):924–928
Italian Association for the Study of the Liver (AISF) (2016) AISF position paper on liver disease and pregnancy. Dig Liver Dis 48(2):120–137
Jaatinen N, Ekholm E (2016) Eclampsia in Finland; 2006 to 2010. Acta Obstet Gynecol Scand 95(7):787–792
Jain K, Grover V, Mahajan R, Batra Y (2004) Effect of varying doses of fentanyl with low dose spinal bupivacaine for caesarean delivery in patients with pregnancy-induced hypertension. Int J Obstet Anesth 13(4):215–220
Judy AE, McCain CL, Lawton ES, Morton CH, Main EK, Druzin ML (2019) Systolic hypertension, preeclampsia-related mortality, and stroke in California. Obstet Gynecol 133(6):1151–1159
Kalafat E, Thilaganathan B (2017) Cardiovascular origins of preeclampsia. Curr Opin Obstet Gynecol 29(6):383–389
Kalafat E, Shirazi A, Thilaganathan B, Khalil A (2020) The role of aspirin in prevention of preeclampsia in twin pregnancies: does the dose matter? Am J Obstet Gynecol 223(3):457–458
Kaufman M, McConnell KJ, Carmichael SL, Rodriguez MI, Richardson D, Snowden JM (2023) Postpartum hostipal readmissions with and without severe maternal morbidity within 1 year of birth, Oregon, 2012–2017. Am J Epidemiol 192(2):158–170
Kehl S, Dotsch J, Hecher K, Schlembach D, Schmitz D, Stepan H, Gembruch U (2017) Intrauterine growth restriction. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry No. 015/080, October 2016). Geburtshilfe Frauenheilkd 77(11):1157–1173
Khan N, Andrade W, De Castro H, Wright A, Wright D, Nicolaides KH (2020) Impact of new definitions of pre-eclampsia on incidence and performance of first-trimester screening. Ultrasound Obstet Gynecol 55(1):50–57
Khashu M, Narayanan M, Bhargava S, Osiovich H (2009) Perinatal outcomes associated with preterm birth at 33 to 36 weeks’ gestation: a population-based cohort study. Pediatrics 123(1):109–113
Khosla K, Heimberger S, Nieman KM, Tung A, Shahul S, Staff AC, Rana S (2021) Long-term cardiovascular disease risk in women after hypertensive disorders of pregnancy: recent advances in hypertension. Hypertension 78(4):927–935
Kirkegaard H, Bliddal M, Stovring H, Rasmussen KM, Gunderson EP, Kober L, Sorensen TIA, Nohr EA (2018) Breastfeeding and later maternal risk of hypertension and cardiovascular disease – the role of overall and abdominal obesity. Prev Med 114:140–148
Klein E, Schlembach D, Ramoni A, Langer E, Bahlmann F, Grill S, Schaffenrath H, Van der Does R, Messinger D, Verhagen-Kamerbeek WD, Reim M, Hund M, Stepan H (2016) Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia. PLoS One 11(5):e0156013
Knight M, UKOSS (2007) Eclampsia in the United Kingdom 2005. BJOG 114(9):1072–1078
Knight M, Nelson-Piercy C, Kurinczuk JJ, Spark P, Brocklehurst P, System UKOS (2008) A prospective national study of acute fatty liver of pregnancy in the UK. Gut 57(7):951–956
Knight M, Bunch K, Tuffnell D, Patel R, Shakespeare J, Kotnis R, Kenyon S, Kurinczuk JJ (Hrsg) on behalf of MBRRACE-UK (2021) Saving Lives, Improving Mothers’ Care – Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2017–19. National Perinatal Epidemiology Unit, University of Oxford, Oxford
Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ, Van den Berg PP, De Boer K, Burggraaff JM, Bloemenkamp KW, Drogtrop AP, Franx A, De Groot CJ, Huisjes AJ, Kwee A, Van Loon AJ, Lub A, Papatsonis DN, Van der Post JA, Roumen FJ, Scheepers HC, Willekes C, Mol BW, Van Pampus MG, Group, H. S (2009) Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial. Lancet 374(9694):979–988
Ku E, Lee BJ, Wei J, Weir MR (2019) Hypertension in CKD: core curriculum 2019. Am J Kidney Dis 74(1):120–131
Kuc S, Wortelboer EJ, Van Rijn BB, Franx A, Visser GH, Schielen PC (2011) Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv 66(4):225–239
Kuklina EV, Ayala C, Callaghan WM (2009) Hypertensive disorders and severe obstetric morbidity in the United States. Obstet Gynecol 113(6):1299–1306
Kumar NR, Eucalitto PF, Trawick E, Lancki N, Yee LM (2022) Examining changes in clinical management and postpartum readmissions for hypertensive disorders of pregnancy over time. Pregnancy Hypertens 30:82–86
Lachmann R, Schlembach D (2013) Präeklampsiescreening. Frauenarzt 54(4):326–331
Lai J, Syngelaki A, Nicolaides KH, Von Dadelszen P, Magee LA (2021) Impact of new definitions of preeclampsia at term on identification of adverse maternal and perinatal outcomes. Am J Obstet Gynecol 224(5):518.e511
Lammert F, Marschall HU, Matern S (2003) Intrahepatic cholestasis of pregnancy. Curr Treat Options Gastroenterol 6(2):123–132
Langesaeter E, Gibbs M, Dyer RA (2015) The role of cardiac output monitoring in obstetric anesthesia. Curr Opin Anaesthesiol 28(3):247–253
Leeners B, Rath W, Kuse S, Neises M, Neumaier-Wagner P (2006) Satisfaction with medical information in women with hypertensive disorders in pregnancy. J Psychosom Res 60(1):39–44
Leeners B, Neumaier-Wagner P, Kuse S, Stiller R, Rath W (2007) Emotional stress and the risk to develop hypertensive diseases in pregnancy. Hypertens Pregnancy 26(2):211–226
Leeners B, Neumaier-Wagner PM, Kuse S, Mutze S, Rudnik-Schoneborn S, Zerres K, Rath W (2011) Recurrence risks of hypertensive diseases in pregnancy after HELLP syndrome. J Perinat Med 39(6):673–678
Lees C, Ferrazzi E (2017) Relevance of haemodynamics in treating pre-eclampsia. Curr Hypertens Rep 19(9):76
Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, Dersimonian R, Esterlitz JR, Raymond EG, Bild DE, Clemens JD, Cutler JA (1997) Trial of calcium to prevent preeclampsia. N Engl J Med 337(2):69–76
Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350(7):672–683
Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA, Group CS (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355(10):992–1005
Li H, Lyu M, Zhao R, Zang Y, Huang P, Li J, Yan Y, Wang Y, Li Z, Han C, Xue F (2022) The maternal-neonatal outcomes of twin pregnancies with preeclampsia and their association with assisted reproductive technology: a retrospective study. Diagnostics (Basel) 12(6):1334
Lia M, Stepan H (2022) Prävention und Prophylaxe der Präeklampsie. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 113–126
Lindheimer MD, Kanter D (2010) Interpreting abnormal proteinuria in pregnancy: the need for a more pathophysiological approach. Obstet Gynecol 115(2 Pt 1):365–375
Lisonkova S, Razaz N, Sabr Y, Muraca GM, Boutin A, Mayer C, Joseph KS, Kramer MS (2020) Maternal risk factors and adverse birth outcomes associated with HELLP syndrome: a population-based study. BJOG 127(10):1189–1198
Liu S, Joseph KS, Liston RM, Bartholomew S, Walker M, Leon JA, Kirby RS, Sauve R, Kramer MS, Maternal Health Study Group of Canadian Perinatal Surveillance, S (2011) Incidence, risk factors, and associated complications of eclampsia. Obstet Gynecol 118(5):987–994
Livergood CM, Hauck J, Mahlum L, Tallmadge M, Russell R, Kulinski J, Palatnik A (2022) Risk of unplanned healthcare utilization in postpartum period for patients with hypertensive disorders of pregnancy. Pregnancy Hypertens 27:189–192
Lowe SA, Bowyer L, Lust K, McMahon LP, Morton MR, North RA, Paech MJ, Said JM, Society of Obstetric Medicine of, A, New, Z (2015) The SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynaecol 55(1):11–16
Madazli R, Yuksel MA, Imamoglu M, Tuten A, Oncul M, Aydin B, Demirayak G (2014) Comparison of clinical and perinatal outcomes in early- and late-onset preeclampsia. Arch Gynecol Obstet 290(1):53–57
Magee LA, Duley L (2003) Oral beta-blockers for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 2012(3):CD002863
Magee LA, Von Dadelszen P, Bohun CM, Rey E, El-Zibdeh M, Stalker S, Ross S, Hewson S, Logan AG, Ohlsson A, Naeem T, Thornton JG, Abdalla M, Walkinshaw S, Brown M, Davis G, Hannah ME (2003) Serious perinatal complications of non-proteinuric hypertension: an international, multicentre, retrospective cohort study. J Obstet Gynaecol Can 25(5):372–382
Magee LA, Miremadi S, Li J, Cheng C, Ensom MH, Carleton B, Cote AM, Von Dadelszen P (2005) Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol 193(1):153–163
Magee LA, Pels A, Helewa M, Rey E, Von Dadelszen P, Group*, C. H. D. O. P. W (2014) Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can 36(5):416–441
Magee LA, Dadelszen PV, Rey E, Ross S, Asztalos E, Murphy KE, Menzies J, Sanchez J, Singer J, Gafni A, Gruslin A, Helewa M, Hutton E, Lee SK, Logan AG, Ganzevoort W, Welch R, Thornton JG, Moutquin J-M (2015a) [59-or]. Pregnancy Hypertens. Int J Womens Cardiovasc Health 5(1):30–31
Magee LA, Pels A, Helewa M, Rey E, Von Dadelszen P, Canadian Hypertensive Disorders of Pregnancy Working, G, Canadian Hypertensive Disorders of Pregnancy, H. D. P. W. G (2015b) The hypertensive disorders of pregnancy (29.3). Best Pract Res Clin Obstet Gynaecol 29(5):643–657
Magee LA, Von Dadelszen P, Rey E, Ross S, Asztalos E, Murphy KE, Menzies J, Sanchez J, Singer J, Gafni A, Gruslin A, Helewa M, Hutton E, Lee SK, Lee T, Logan AG, Ganzevoort W, Welch R, Thornton JG, Moutquin JM (2015c) Less-tight versus tight control of hypertension in pregnancy. N Engl J Med 372(5):407–417
Magee LA, Von Dadelszen P, Singer J, Lee T, Rey E, Ross S, Asztalos E, Murphy KE, Menzies J, Sanchez J, Gafni A, Helewa M, Hutton E, Koren G, Lee SK, Logan AG, Ganzevoort W, Welch R, Thornton JG, Moutquin JM, Group*, C. S (2016) The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study): is severe hypertension just an elevated blood pressure? Hypertension 68(5):1153–1159
Magee LA, Singer J, Lee T, Rey E, Asztalos E, Hutton E, Helewa M, Logan AG, Ganzevoort W, Welch R, Thornton JG, Woo Kinshella ML, Green M, Tsigas E, Von Dadelszen P, Group CS (2021) The impact of pre-eclampsia definitions on the identification of adverse outcome risk in hypertensive pregnancy – analyses from the CHIPS trial (Control of Hypertension in Pregnancy Study). BJOG 128(8):1373–1382
Magee LA, Brown MA, Hall DR, Gupte S, Hennessy A, Karumanchi SA, Kenny LC, McCarthy F, Myers J, Poon LC, Rana S, Saito S, Staff AC, Tsigas E, Von Dadelszen P (2022) The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens 27:148–169
Magpie Trial Follow-Up Study Collaborative, G (2007a) The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months. BJOG 114(3):289–299
Magpie Trial Follow-Up Study Collaborative, G (2007b) The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years. BJOG 114(3):300–309
Makrides M, Crosby DD, Bain E, Crowther CA (2014) Magnesium supplementation in pregnancy. Cochrane Database Syst Rev 4:CD000937
Malin G, Bell SC, Waugh JJ (2007) Random albumin/creatinine ratio for quantification of proteinuria in manifest pre-eclampsia. BJOG 114(1):118–119; author reply 119
Mao M, Chen C (2015) Corticosteroid therapy for management of Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome: a meta-analysis. Med Sci Monit 21:3777–3783
Marchand A, Galen RS, Van Lente F (1980) The predictive value of serum haptoglobin in hemolytic disease. JAMA 243(19):1909–1911
Martin JN Jr, Blake PG, Perry KG Jr, Mccaul JF, Hess LW, Martin RW (1991) The natural history of HELLP syndrome: patterns of disease progression and regression. Am J Obstet Gynecol 164(6 Pt 1):1500–1509; discussion 1509–1513
Martin JN Jr, May WL, Magann EF, Terrone DA, Rinehart BK, Blake PG (1999a) Early risk assessment of severe preeclampsia: admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity. Am J Obstet Gynecol 180(6 Pt 1):1407–1414
Martin JN Jr, Rinehart BK, May WL, Magann EF, Terrone DA, Blake PG (1999b) The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. Am J Obstet Gynecol 180(6 Pt 1):1373–1384
Martin JN Jr, Thigpen BD, Moore RC, Rose CH, Cushman J, May W (2005) Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure. Obstet Gynecol 105(2):246–254
Martin JN Jr (2013) Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia). Int J Gynaecol Obstet 121(3):202–207
Martinelli I, Ruggenenti P, Cetin I, Pardi G, Perna A, Vergani P, Acaia B, Facchinetti F, La Sala GB, Bozzo M, Rampello S, Marozio L, Diadei O, Gherardi G, Carminati S, Remuzzi G, Mannucci PM, Group HS (2012) Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. Blood 119(14):3269–3275
Mattar F, Sibai BM (2000) Eclampsia. VIII. Risk factors for maternal morbidity. Am J Obstet Gynecol 182(2):307–312
Mayama M, Uno K, Tano S, Yoshihara M, Ukai M, Kishigami Y, Ito Y, Oguchi H (2016) Incidence of posterior reversible encephalopathy syndrome in eclamptic and patients with preeclampsia with neurologic symptoms. Am J Obstet Gynecol 215(2):239. e231–235
Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111(5):649–658
McCarthy FP, Gill C, Seed PT, Bramham K, Chappell LC, Shennan AH (2019) Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study. Ultrasound Obstet Gynecol 53(1):62–67
McDermott M, Miller EC, Rundek T, Hurn PD, Bushnell CD (2018) Preeclampsia: association with posterior reversible encephalopathy syndrome and stroke. Stroke 49(3):524–530
McLaughlin K, Hobson SR, Chandran AR, Agrawal S, Windrim RC, Parks WT, Bowman AW, Sovio U, Smith GC, Kingdom JC (2022) Circulating maternal placental growth factor responses to low-molecular-weight heparin in pregnant patients at risk of placental dysfunction. Am J Obstet Gynecol 226(2S):S1145–S1156. e1141
Meads CA, Cnossen JS, Meher S, Juarez-Garcia A, Ter Riet G, Duley L, Roberts TE, Mol BW, Van der Post JA, Leeflang MM, Barton PM, Hyde CJ, Gupta JK, Khan KS (2008) Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess 12(6):iii–iv, 1–270
Mebazaa A, Yilmaz MB, Levy P, Ponikowski P, Peacock WF, Laribi S, Ristic AD, Lambrinou E, Masip J, Riley JP, Mcdonagh T, Mueller C, Defilippi C, Harjola VP, Thiele H, Piepoli MF, Metra M, Maggioni A, McMurray J, Dickstein K, Damman K, Seferovic PM, Ruschitzka F, Leite-Moreira AF, Bellou A, Anker SD, Filippatos G (2015) Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine. Eur J Heart Fail 17(6):544–558
Meher S, Duley L (2006a) Garlic for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 3:CD006065
Meher S, Duley L (2006b) Progesterone for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 4:CD006175
Meher S, Duley L, Hunter K, Askie L (2017) Antiplatelet therapy before or after 16 weeks’ gestation for preventing preeclampsia: an individual participant data meta-analysis. Am J Obstet Gynecol 216(2):121–128 e122
Melchiorre K, Sutherland G, Sharma R, Nanni M, Thilaganathan B (2013) Mid-gestational maternal cardiovascular profile in preterm and term pre-eclampsia: a prospective study. BJOG 120(4):496–504
Millman AL, Payne B, Qu Z, Joanne Douglas M, Hutcheon JA, Lee T, Magee LA, Walley KR, Von Dadelszen P, Group, P. S (2011) Oxygen saturation as a predictor of adverse maternal outcomes in women with preeclampsia. J Obstet Gynaecol Can 33(7):705–714
Moatti Z, Gupta M, Yadava R, Thamban S (2014) A review of stroke and pregnancy: incidence, management and prevention. Eur J Obstet Gynecol Reprod Biol 181:20–27
Moe K, Sugulle M, Dechend R, Staff AC (2020) Risk prediction of maternal cardiovascular disease one year after hypertensive pregnancy complications or gestational diabetes mellitus. Eur J Prev Cardiol 27(12):1273–1283
Mohta M, Lakshmi R, Chilkoti GT, Agarwal R, Malhotra RK (2021) A randomised double-blind comparison of phenylephrine and norepinephrine for the management of postspinal hypotension in pre-eclamptic patients undergoing caesarean section. Eur J Anaesthesiol 38(10):1077–1084
Molvarec A, Prohaszka Z, Nagy B, Kalabay L, Szalay J, Fust G, Karadi I, Rigo J Jr (2007) Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J Reprod Immunol 73(2):172–179
Monden C, Pison G, Smits J (2021) Twin Peaks: more twinning in humans than ever before. Hum Reprod 36(6):1666–1673
Moran P, Lindheimer MD, Davison JM (2004) The renal response to preeclampsia. Semin Nephrol 24(6):588–595
Morgan JL, Nelson DB, Roberts SW, Wells CE, McIntire DD, Cunningham FG (2016) Blood pressure profiles across pregnancy in women with chronic hypertension. Am J Perinatol 33(12):1128–1132
Moroz LA, Simpson LL, Rochelson B (2016) Management of severe hypertension in pregnancy. Semin Perinatol 40(2):112–118
Morris RK, Riley RD, Doug M, Deeks JJ, Kilby MD (2012) Diagnostic accuracy of spot urinary protein and albumin to creatinine ratios for detection of significant proteinuria or adverse pregnancy outcome in patients with suspected pre-eclampsia: systematic review and meta-analysis. BMJ 345:e4342
Mostello D, Kallogjeri D, Tungsiripat R, Leet T (2008) Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol 199(1):55. e51–57
Moussa HN, Leon MG, Marti A, Chediak A, Pedroza C, Blackwell SC, Sibai BM (2017) Pregnancy outcomes in women with preeclampsia superimposed on chronic hypertension with and without severe features. Am J Perinatol 34(4):403–408
Mulcahy C, McAuliffe FM (2022) Routine Doppler ultrasound in twin pregnancy. Best Pract Res Clin Obstet Gynaecol 84:43–54
Münch J, Lindner TH (2022) Ätiologie und Pathogenese: Genetik. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 61–82
Myatt L, Roberts JM (2015) Preeclampsia: syndrome or disease? Curr Hypertens Rep 17(11):83
Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Iams JD, Sciscione A, Harper M, Tolosa JE, Saade G, Sorokin Y, Anderson GD, Eunice Kennedy Shriver National Institute of Child, H, Human Development Maternal-Fetal Medicine Units, N (2012) First-trimester prediction of preeclampsia in nulliparous women at low risk. Obstet Gynecol 119(6):1234–1242
Nagai Y, Arai H, Washizawa Y, Ger Y, Tanaka M, Maeda M, Kawamura S (1991) FSGS-like lesions in pre-eclampsia. Clin Nephrol 36(3):134–140
Nasab SH, Moussa HN, Alrais MA, Sibai BM, Blackwell SC (2018) Postpartum readmissions: what we can learn from numbers? [18K]. Obstet Gynecol 131(1):123S–123S
Nayak AS, Nachane HB (2018) Risk analysis of suicidal ideations and postpartum depression with antenatal alpha methyldopa use. Asian J Psychiatr 38:42–44
Nelson DB, Yost NP, Cunningham FG (2013) Acute fatty liver of pregnancy: clinical outcomes and expected duration of recovery. Am J Obstet Gynecol 209(5):456. e451–457
Neuhauser HK, Adler C, Rosario AS, Diederichs C, Ellert U (2015) Hypertension prevalence, awareness, treatment and control in Germany 1998 and 2008–11. J Hum Hypertens 29(4):247–253
Nice Multiple Obstetric Guidelines Update Committee (2019) Hypertension in pregnancy: diagnosis and management – NICE guideline [NG133]. National Institute for Health and Care Excellence, London
Nisell H, Lintu H, Lunell NO, Mollerstrom G, Pettersson E (1995) Blood pressure and renal function seven years after pregnancy complicated by hypertension. Br J Obstet Gynaecol 102(11):876–881
O’Brien E, Asmar R, Beilin L, Imai Y, Mancia G, Mengden T, Myers M, Padfield P, Palatini P, Parati G, Pickering T, Redon J, Staessen J, Stergiou G, Verdecchia P, European Society of Hypertension Working Group on Blood Pressure, M (2005) Practice guidelines of the European Society of Hypertension for clinic, ambulatory and self blood pressure measurement. J Hypertens 23(4):697–701
O’Gorman N, Nicolaides KH, Poon LC (2016a) The use of ultrasound and other markers for early detection of preeclampsia. Womens Health (Lond) 12(2):199–207
O’Gorman N, Wright D, Syngelaki A, Akolekar R, Wright A, Poon LC, Nicolaides KH (2016b) Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11–13 weeks gestation. Am J Obstet Gynecol 214(1):103 e101–103 e112
O’Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, de Alvarado M, Carbone IF, Dutemeyer V, Fiolna M, Frick A, Karagiotis N, Mastrodima S, De Paco Matallana C, Papaioannou G, Pazos A, Plasencia W, Nicolaides KH (2017a) Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol 49(6):756–760
O’Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, Wright A, Akolekar R, Cicero S, Janga D, Jani J, Molina FS, De Paco Matallana C, Papantoniou N, Persico N, Plasencia W, Singh M, Nicolaides KH (2017b) Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation. Ultrasound Obstet Gynecol 49(6):751–755
Ochsenbein-Kolble N, Roos M, Gasser T, Zimmermann R (2007) Cross-sectional study of weight gain and increase in BMI throughout pregnancy. Eur J Obstet Gynecol Reprod Biol 130(2):180–186
Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R (2000) Preeclampsia and fetal growth. Obstet Gynecol 96(6):950–955
Okby R, Harlev A, Sacks KN, Sergienko R, Sheiner E (2018) Preeclampsia acts differently in in vitro fertilization versus spontaneous twins. Arch Gynecol Obstet 297(3):653–658
Olde E, Van der Hart O, Kleber R, Van Son M (2006) Posttraumatic stress following childbirth: a review. Clin Psychol Rev 26(1):1–16
Opdahl S, Henningsen AA, Tiitinen A, Bergh C, Pinborg A, Romundstad PR, Wennerholm UB, Gissler M, Skjaerven R, Romundstad LB (2015) Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod 30(7):1724–1731
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Ilio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiu MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackiene J, Koster MPH, Kowalska-Kanka A, Kupcinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Yayla Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C (2019) Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet 393(10174):899–909
Palit S, Palit G, Vercauteren M, Jacquemyn Y (2009) Regional anaesthesia for primary caesarean section in patients with preterm HELLP syndrome: a review of 102 cases. Clin Exp Obstet Gynecol 36(4):230–234
Pant M, Fong R, Scavone B (2014) Prevention of peri-induction hypertension in preeclamptic patients: a focused review. Anesth Analg 119(6):1350–1356
Papageorghiou AT, Leslie K (2007) Uterine artery Doppler in the prediction of adverse pregnancy outcome. Curr Opin Obstet Gynecol 19(2):103–109
Papageorghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening, G (2001) Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18(5):441–449
Park S, Choi NK (2018) Breastfeeding and maternal hypertension. Am J Hypertens 31(5):615–621
Paternoster DM, Fantinato S, Stella A, Nanhorngue KN, Milani M, Plebani M, Nicolini U, Girolami A (2006) C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb Hemost 12(3):330–337
Paul RH, Koh KS, Bernstein SG (1978) Changes in fetal heart rate-uterine contraction patterns associated with eclampsia. Am J Obstet Gynecol 130(2):165–169
Pawelec M, Palczynski B, Karmowski A (2012) HELLP syndrome in pregnancies below 26th week. J Matern Fetal Neonatal Med 25(5):467–470
Payne BA, Hutcheon JA, Ansermino JM, Hall DR, Bhutta ZA, Bhutta SZ, Biryabarema C, Grobman WA, Groen H, Haniff F, Li J, Magee LA, Merialdi M, Nakimuli A, Qu Z, Sikandar R, Sass N, Sawchuck D, Steyn DW, Widmer M, Zhou J, Von Dadelszen P, Mini PSWG (2014) A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) multi-country prospective cohort study. PLoS Med 11(1):e1001589
Pecks U (2022a) Definition. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 3–22
Pecks U (2022b) Epidemiologie. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 23–36
Pecks U, Maass N, Neulen J (2011) Oocyte donation: a risk factor for pregnancy-induced hypertension: a meta-analysis and case series. Dtsch Arztebl Int 108(3):23–31
Perkins AV, Vanderlelie JJ (2016) Multiple micronutrient supplementation and birth outcomes: the potential importance of selenium. Placenta 48(Suppl 1):S61–S65
Pettit F, Brown MA (2012) The management of pre-eclampsia: what we think we know. Eur J Obstet Gynecol Reprod Biol 160(1):6–12
Phelan LK, Brown MA, Davis GK, Mangos G (2004) A prospective study of the impact of automated dipstick urinalysis on the diagnosis of preeclampsia. Hypertens Pregnancy 23(2):135–142
Poldre PA (1987) Haptoglobin helps diagnose the HELLP syndrome. Am J Obstet Gynecol 157(5):1267
Poniedzialek-Czajkowska E, Mierzynski R, Dluski D, Leszczynska-Gorzelak B (2021) Prevention of hypertensive disorders of pregnancy-is there a place for metformin? J Clin Med 10(13):2805
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, Van der Meer P (2016) 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Rev Esp Cardiol (Engl Ed) 69(12):1167
Poon LC, Galindo A, Surbek D, Chantraine F, Stepan H, Hyett J, Tan KH, Verlohren S (2020) From first-trimester screening to risk stratification of evolving pre-eclampsia in second and third trimesters of pregnancy: comprehensive approach. Ultrasound Obstet Gynecol 55(1):5–12
Poon LC, Magee LA, Verlohren S, Shennan A, Von Dadelszen P, Sheiner E, Hadar E, Visser G, Da Silva Costa F, Kapur A, McAuliffe F, Nazareth A, Tahlak M, Kihara AB, Divakar H, McIntyre HD, Berghella V, Yang H, Romero R, Nicolaides KH, Melamed N, Hod M (2021) A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre-eclampsia: compiled by the Pregnancy and Non-Communicable Diseases Committee of FIGO (the International Federation of Gynecology and Obstetrics). Int J Gynaecol Obstet 154(Suppl 1):3–31
Pourrat O, Pierre F (2010) [Medical assessment after a pre-eclampsia: why? for whom? when? how? for what purpose?]. Rev Med Interne 31(11):766–771
Pourrat O, Coudroy R, Pierre F (2015) Differentiation between severe HELLP syndrome and thrombotic microangiopathy, thrombotic thrombocytopenic purpura and other imitators. Eur J Obstet Gynecol Reprod Biol 189:68–72
Purde MT, Baumann M, Wiedemann U, Nydegger UE, Risch L, Surbek D, Risch M (2015) Incidence of preeclampsia in pregnant Swiss women. Swiss Med Wkly 145:w14175
Raio L, Baumann M, Schneider H (2015) Hypertensive Schwangerschaftserkrankungen. In: Schneider H, Husslein P-W, Schneider KTM (Hrsg) Die Geburtshilfe. Springer Berlin Heidelberg, Berlin/Heidelberg, S 1–71
Rameez RM, Sadana D, Kaur S, Ahmed T, Patel J, Khan MS, Misbah S, Simonson MT, Riaz H, Ahmed HM (2019) Association of maternal lactation with diabetes and hypertension: a systematic review and meta-analysis. JAMA Netw Open 2(10):e1913401
Rana S, Powe CE, Salahuddin S, Verlohren S, Perschel FH, Levine RJ, Lim KH, Wenger JB, Thadhani R, Karumanchi SA (2012) Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation 125(7):911–919
Rasmussen S, Irgens LM (2003) Fetal growth and body proportion in preeclampsia. Obstet Gynecol 101(3):575–583
Rath W (1998) Das HELLP-Syndrom – eine interdisziplinäre Herausforderung. Dtsch Arztebl 95(47):2997–3002
Rath W (2009) Hypertensive Schwangerschaftserkrankungen. In: Rath W, Friese K (Hrsg) Erkrankungen in der Schwangerschaft. Thieme, Stuttgart/New York, S 73–97
Rath W, Schlembach D (2020) Ambulante Betreuung hypertensiver Schwangerer, Empfehlungen aus Leitlinien. Frauenarzt 61(10):678–683
Rath W, Loos W, Graeff H, Kuhn W (1992) HELLP-Syndrom. Gynäkologe 25(6):430–440
Rath W, Faridi A, Dudenhausen JW (2000) HELLP syndrome. J Perinat Med 28(4):249–260
Rath W, Tsikouras P, Schlembach D (2020a) Ambulante und häusliche Blutdruckmessung bei hypertensiven Schwangeren. [Ambulatory and home blood pressure measurement in hypertensive pregnant women]. Z Geburtshilfe Neonatol 224(6):333–338
Rath W, Tsikouras P, Stelzl P (2020b) HELLP syndrome or acute fatty liver of pregnancy: a differential diagnostic challenge: common features and differences. Geburtshilfe Frauenheilkd 80(5):499–507
Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA (2005) Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet 366(9499):1797–1803
Reddy M, Fenn S, Rolnik DL, Mol BW, Da Silva Costa F, Wallace EM, Palmer KR (2021) The impact of the definition of preeclampsia on disease diagnosis and outcomes: a retrospective cohort study. Am J Obstet Gynecol 224(2):217.e211
Redman CW, Roberts JM (1993) Management of pre-eclampsia. Lancet 341(8858):1451–1454
Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308(5728):1592–1594
Reimer T, Rohrmann H, Stubert J, Pecks U, Glocker MO, Richter DU, Gerber B (2013) Angiogenic factors and acute-phase proteins in serum samples of preeclampsia and HELLP patients: a matched-pair analysis. J Matern Fetal Neonatal Med 26(3):263–269
Rich-Edwards JW, Stuart JJ, Skurnik G, Roche AT, Tsigas E, Fitzmaurice GM, Wilkins-Haug LE, Levkoff SE, Seely EW (2019) Randomized trial to reduce cardiovascular risk in women with recent preeclampsia. J Womens Health (Larchmt) 28(11):1493–1504
Ridder A, Giorgione V, Khalil A, Thilaganathan B (2019) Preeclampsia: the relationship between uterine artery blood flow and trophoblast function. Int J Mol Sci 20(13):3263
Rimoldi SF, Scherrer U, Messerli FH (2014) Secondary arterial hypertension: when, who, and how to screen? Eur Heart J 35(19):1245–1254
Rizzo G, Pietrolucci ME, Aiello E, Capponi A, Arduini D (2014) Uterine artery Doppler evaluation in twin pregnancies at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol 44(5):557–561
Roberge S, Villa P, Nicolaides K, Giguere Y, Vainio M, Bakthi A, Ebrashy A, Bujold E (2012) Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Fetal Diagn Ther 31(3):141–146
Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E (2017) The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol 216(2):110–120 e116
Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, McLeod A, Khandelwal M, Silver RM, Le Gal G, Greer IA, Keely E, Rosene-Montella K, Walker M, Wells PS (2014) Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 384(9955):1673–1683
Rodger MA, Gris JC, De Vries JIP, Martinelli I, Rey E, Schleussner E, Middeldorp S, Kaaja R, Langlois NJ, Ramsay T, Mallick R, Bates SM, Abheiden CNH, Perna A, Petroff D, De Jong P, Van Hoorn ME, Bezemer PD, Mayhew AD, Low-Molecular-Weight Heparin For Placenta-Mediated Pregnancy Complications Study, G (2016) Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials. Lancet 388(10060):2629–2641
Rodrigues A, Barata C, Marques I, Almeida MC (2018) Diagnosis of white coat hypertension and pregnancy outcomes. Pregnancy Hypertens 14:121–124
Rodriguez A, Tuuli MG, Odibo AO (2016) First-, second-, and third-trimester screening for preeclampsia and intrauterine growth restriction. Clin Lab Med 36(2):331–351
Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, De Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH (2017a) Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med 377(7):613–622
Rolnik DL, Wright D, Poon LCY, Syngelaki A, O’Gorman N, De Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Nicolaides KH (2017b) ASPRE trial: performance of screening for preterm pre-eclampsia. Ultrasound Obstet Gynecol 50(4):492–495
Roofthooft E, Joshi G, Rawal N, Van de Velde M, Prospect, W. G. O. T. E. S. O. R. A. A. P. T. A. S. B. T. O. A. A (2021) PROSPECT guideline for elective caesarean section: updated systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia 76(5):665–680
Ropponen A, Sund R, Riikonen S, Ylikorkala O, Aittomaki K (2006) Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. Hepatology 43(4):723–728
Rotchell YE, Cruickshank JK, Gay MP, Griffiths J, Stewart A, Farrell B, Ayers S, Hennis A, Grant A, Duley L, Collins R (1998) Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol 105(3):286–292
Runnard Heimel PJ van, Franx A, Schobben AF, Huisjes AJ, Derks JB, Bruinse HW (2005) Corticosteroids, pregnancy, and HELLP syndrome: a review. Obstet Gynecol Surv 60(1):57–70; quiz 73–54
Runnard Heimel PJ van, Kavelaars A, Heijnen CJ, Peters WH, Huisjes AJ, Franx A, Bruinse HW (2008) HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. Hypertens Pregnancy 27(3):253–265
Saccone G, Saccone I, Berghella V (2016) Omega-3 long-chain polyunsaturated fatty acids and fish oil supplementation during pregnancy: which evidence? J Matern Fetal Neonatal Med 29(15):2389–2397
Sanchez O, Llurba E, Marsal G, Dominguez C, Aulesa C, Sanchez-Duran MA, Goya MM, Alijotas-Reig J, Carreras E, Cabero L (2012) First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology. Hum Reprod 27(2):358–365
Sanchez-Aranguren LC, Prada CE, Riano-Medina CE, Lopez M (2014) Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol 5:372
Sanner B (2008) Richtig Blutdruck messen. Druckpunkt 3:14–17
Sarno L, Maruotti GM, Saccone G, Sirico A, Mazzarelli LL, Martinelli P (2015) Pregnancy outcome in proteinuria-onset and hypertension-onset preeclampsia. Hypertens Pregnancy 34(3):284–290
Saudan P, Brown MA, Buddle ML, Jones M (1998) Does gestational hypertension become pre-eclampsia? Br J Obstet Gynaecol 105(11):1177–1184
Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, Gulmezoglu AM, Temmerman M, Alkema L (2014) Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health 2(6):e323–e333
Scazzocchio E, Figueras F (2011) Contemporary prediction of preeclampsia. Curr Opin Obstet Gynecol 23(2):65–71
Schaefer C, Spielmann H, Vetter K, Weber-Schöndorfer C (2011) Arzneimittel in Schwangerschaft und Stillzeit, 8. Aufl. Urban & Fischer/Elsevier GmbH, London
Schikowski T, Wigmann C, Fuks KB, Schipf S, Heier M, Neuhauser H, Sarganas G, Ahrens W, Becher H, Berger K, Brenner H, Castell S, Damms-Machado A, Dorr M, Ebert N, Efremov L, Emmel C, Felix SB, Fischer B, Franzke CW, Gastell S, Gunther K, Haerting J, Ittermann T, Jaeschke L, Jagodzinski A, Jockel KH, Kaaks R, Kalinowski S, Keil T, Kemmling Y, Kluttig A, Krist L, Kuss O, Legath N, Leitzmann M, Lieb W, Loffler M, Meinke-Franze C, Michels KB, Mikolajczyk R, Moebus S, Nuding S, Peters A, Pischon T, Ruckert-Eheberg IM, Schottker B, Schmidt B, Schmidt CO, Schulze MB, Stang A, Thiele I, Thierry S, Thorand B, Volzke H, Waniek S, Werdan K, Wirkner K, Greiser KH (2020) [Blood pressure measurement in the NAKO German National Cohort (GNC) – differences in methods, distribution of blood pressure values, and awareness of hypertension compared to other population-based studies in Germany]. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 63(4):452–464
Schlembach D (2003) Preeclampsia – still a disease of theories. Fukushima J Med Sci 49(2):69–115
Schlembach D, Homuth V, Dechend R (2015) Treating hypertension in pregnancy. Curr Hypertens Rep 17(8):63
Schlembach D, Stepan H, Groten T, Maul H, Pecks U, Verlohren S, Wertaschnigg D, Binder J, Raio L, Lapaire O, Reitz D, Scharrel D, Treskatsch S, Gross M, Bercz E, Winkler K, Dechend R, Von der Wense A (2019) Hypertensive pregnancy disorders: diagnosis and therapy. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF-Registry No. 015/018, March 2019)
Schleussner E, Kamin G, Seliger G, Rogenhofer N, Ebner S, Toth B, Schenk M, Henes M, Bohlmann MK, Fischer T, Brosteanu O, Bauersachs R, Petroff D, Group, E. I (2015) Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme. Ann Intern Med 162(9):601–609
Schrey-Petersen S, Stepan H (2017) Anti-angiogenesis and preeclampsia in 2016. Curr Hypertens Rep 19(1):6
Schwartz ML, Lien JM (1997) Spontaneous liver hematoma in pregnancy not clearly associated with preeclampsia: a case presentation and literature review. Am J Obstet Gynecol 176(6):1328–1333
Sciscione AC, Ivester T, Largoza M, Manley J, Shlossman P, Colmorgen GH (2003) Acute pulmonary edema in pregnancy. Obstet Gynecol 101(3):511–515
Scott JS (1958) Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios. J Obstet Gynaecol Br Emp 65(5):689–701
Scully M (2016) Thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome microangiopathy in pregnancy. Semin Thromb Hemost 42(7):774–779
Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, McDonald V, Roy A, Evans G, Mcguckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O’Brien P, Collaborators of the, U. K. T. T. P. R (2014) Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes. Blood 124(2):211–219
Scully M, Cataland SR, Peyvandi F, Coppo P, Knobl P, Kremer Hovinga JA, Metjian A, De La Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK, Investigators H (2019) Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med 380(4):335–346
Seal SL, Ghosh D, Kamilya G, Mukherji J, Hazra A, Garain P (2012) Does route of delivery affect maternal and perinatal outcome in women with eclampsia? A randomized controlled pilot study. Am J Obstet Gynecol 206(6):484. e481–487
Seely EW, Ecker J (2011) Clinical practice. Chronic hypertension in pregnancy. N Engl J Med 365(5):439–446
Seely EW, Ecker J (2014) Chronic hypertension in pregnancy. Circulation 129(11):1254–1261
Shennan AH, Green M, Chappell LC (2017) Maternal deaths in the UK: pre-eclampsia deaths are avoidable. Lancet 389(10069):582–584
Shih T, Peneva D, Xu X, Sutton A, Triche E, Ehrenkranz RA, Paidas M, Stevens W (2016) The rising burden of preeclampsia in the United States impacts both maternal and child health. Am J Perinatol 33(4):329–338
Shinar S, Melamed N, Abdulaziz KE, Ray JG, Riddell C, Barrett J, Murray-Davis B, Mawjee K, McDonald SD, Geary M, Berger H, For Doh-Net SI (2021) Changes in rate of preterm birth and adverse pregnancy outcomes attributed to preeclampsia after introduction of a refined definition of preeclampsia: a population-based study. Acta Obstet Gynecol Scand 100(9):1627–1635
Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365(9461):785–799
Sibai BM (1996) Treatment of hypertension in pregnant women. N Engl J Med 335(4):257–265
Sibai BM (2002) Chronic hypertension in pregnancy. Obstet Gynecol 100(2):369–377
Sibai BM (2004) Magnesium sulfate prophylaxis in preeclampsia: lessons learned from recent trials. Am J Obstet Gynecol 190(6):1520–1526
Sibai BM (2005) Diagnosis, prevention, and management of eclampsia. Obstet Gynecol 105(2):402–410
Sibai BM (2022) HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets). https://www.uptodate.com/contents/hellp-syndrome-hemolysis-elevated-liver-enzymes-and-low-platelets?search=HELLP&source=search_result&selectedTitle=1~84&usage_type=default&display_rank=1. Zugegriffen am 13.07.2023
Sibai BM, Ramadan MK (1993) Acute renal failure in pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets. Am J Obstet Gynecol 168(6 Pt 1):1682–1687; discussion 1687–1690
Sibai BM, Lipshitz J, Anderson GD, Dilts PV Jr (1981) Reassessment of intravenous MgSO4 therapy in preeclampsia-eclampsia. Obstet Gynecol 57(2):199–202
Sibai BM, Mercer B, Sarinoglu C (1991) Severe preeclampsia in the second trimester: recurrence risk and long-term prognosis. Am J Obstet Gynecol 165(5 Pt 1):1408–1412
Sibai BM, Ramadan MK, Usta I, Salama M, Mercer BM, Friedman SA (1993) Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 169(4):1000–1006
Silberstein T, Levy A, Harlev A, Saphier O, Sheiner E (2014) Perinatal outcome of pregnancies following in vitro fertilization and ovulation induction. J Matern Fetal Neonatal Med 27(13):1316–1319
Simpson LL (2002) Maternal medical disease: risk of antepartum fetal death. Semin Perinatol 26(1):42–50
Simpson M, Schmied V, Dickson C, Dahlen HG (2018) Postnatal post-traumatic stress: an integrative review. Women Birth 31:367–379
Sites CK, Wilson D, Bernson D, Boulet S, Zhang Y (2020) Number of embryos transferred and diagnosis of preeclampsia. Reprod Biol Endocrinol 18(1):68
Skeith L, Rodger M (2017) Anticoagulants to prevent recurrent placenta-mediated pregnancy complications: is it time to put the needles away? Thromb Res 151:S38–S42
Skjaerven R, Wilcox AJ, Klungsoyr K, Irgens LM, Vikse BE, Vatten LJ, Lie RT (2012) Cardiovascular mortality after pre-eclampsia in one child mothers: prospective, population based cohort study. BMJ 345:e7677
Skliut M, Jamieson DG (2016) Imaging of headache in pregnancy. Curr Pain Headache Rep 20(10):56
Smith JM, Lowe RF, Fullerton J, Currie SM, Harris L, Felker-Kantor E (2013) An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management. BMC Pregnancy Childbirth 13:34
Society For Maternal-Fetal Medicine (2022) Society for Maternal-Fetal Medicine Statement: antihypertensive therapy for mild chronic hypertension in pregnancy: the CHAP trial. Am J Obstet Gynecol 227:B24–B27
Sohlberg S, Mulic-Lutvica A, Lindgren P, Ortiz-Nieto F, Wikstrom AK, Wikstrom J (2014) Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study. Placenta 35(3):202–206
Solomon CG, Greene MF (2015) Control of hypertension in pregnancy – if some is good, is more worse? N Engl J Med 372(5):475–476
Sotiriadis A, Hernandez-Andrade E, Da Silva Costa F, Ghi T, Glanc P, Khalil A, Martins WP, Odibo AO, Papageorghiou AT, Salomon LJ, Thilaganathan B, Force ICP-ET (2019) ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia. Ultrasound Obstet Gynecol 53(1):7–22
Sovio U, Gaccioli F, Cook E, Hund M, Charnock-Jones DS, Smith GC (2017) Prediction of preeclampsia using the soluble fms-like tyrosine kinase 1 to placental growth factor ratio: a prospective cohort study of unselected nulliparous women. Hypertension 69(4):731–738
Spaan JJ, Ekhart T, Spaanderman ME, Peeters LL (2012) Renal function after preeclampsia: a longitudinal pilot study. Nephron Clin Pract 120(3):c156–c161
Staykov D, Schwab S (2012) [Posterior reversible encephalopathy syndrome]. Nervenarzt 83(8):1013–1020
Steegers EA, Von Dadelszen P, Duvekot JJ, Pijnenborg R (2010) Pre-eclampsia. Lancet 376(9741):631–644
Stella CL, Dacus J, Guzman E, Dhillon P, Coppage K, How H, Sibai B (2009) The diagnostic dilemma of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the obstetric triage and emergency department: lessons from 4 tertiary hospitals. Am J Obstet Gynecol 200(4):381. e381–386
Stepan H, Galindo A, Hund M, Schlembach D, Sillman J, Surbek D, Vatish M (2023) Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction. Ultrasound Obstet Gynecol 61(2):168–180
Stuart JJ, Tanz LJ, Missmer SA, Rimm EB, Spiegelman D, James-Todd TM, Rich-Edwards JW (2018) Hypertensive disorders of pregnancy and maternal cardiovascular disease risk factor development: an observational cohort study. Ann Intern Med 169(4):224–232
Stubert J (2022) Entbindung bei Präeklampsie. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 215–238
Subtil D, Goeusse P, Puech F, Lequien P, Biausque S, Breart G, Uzan S, Marquis P, Parmentier D, Churlet A, Essai Regional Aspirine Mere-Enfant Collaborative, G (2003) Aspirin (100 mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 1). BJOG 110(5):475–484
Tan MY, Wright D, Syngelaki A, Akolekar R, Cicero S, Janga D, Singh M, Greco E, Wright A, Maclagan K, Poon LC, Nicolaides KH (2018) Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound Obstet Gynecol 51(6):743–750
Tay J, Foo L, Masini G, Bennett PR, Mceniery CM, Wilkinson IB, Lees CC (2018) Early and late preeclampsia are characterized by high cardiac output, but in the presence of fetal growth restriction, cardiac output is low: insights from a prospective study. Am J Obstet Gynecol 218(5):517.e511–517.e512
Thadhani R, Kisner T, Hagmann H, Bossung V, Noack S, Schaarschmidt W, Jank A, Kribs A, Cornely OA, Kreyssig C, Hemphill L, Rigby AC, Khedkar S, Lindner TH, Mallmann P, Stepan H, Karumanchi SA, Benzing T (2011) Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation 124(8):940–950
Thangaratinam S, Allotey J, Marlin N, Dodds J, Cheong-See F, Von Dadelszen P, Ganzevoort W, Akkermans J, Kerry S, Mol BW, Moons KG, Riley RD, Khan KS, Network PC (2017a) Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models. BMC Med 15(1):68
Thangaratinam S, Allotey J, Marlin N, Mol BW, Von Dadelszen P, Ganzevoort W, Akkermans J, Ahmed A, Daniels J, Deeks J, Ismail K, Barnard AM, Dodds J, Kerry S, Moons C, Riley RD, Khan KS (2017b) Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study. Health Technol Assess 21(18):1–100
The Eclampsia Trial Collaborative Group (1995) Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 345(8963):1455–1463
Theilen LH, Fraser A, Hollingshaus MS, Schliep KC, Varner MW, Smith KR, Esplin MS (2016) All-cause and cause-specific mortality after hypertensive disease of pregnancy. Obstet Gynecol 128(2):238–244
Thilaganathan B, Kalafat E (2019) Cardiovascular system in preeclampsia and beyond. Hypertension 73(3):522–531
Thilaganathan B, Wormald B, Zanardini C, Sheldon J, Ralph E, Papageorghiou AT (2010) Early-pregnancy multiple serum markers and second-trimester uterine artery Doppler in predicting preeclampsia. Obstet Gynecol 115(6):1233–1238
Thornton CE, Von Dadelszen P, Makris A, Tooher JM, Ogle RF, Hennessy A (2011) Acute pulmonary oedema as a complication of hypertension during pregnancy. Hypertens Pregnancy 30(2):169–179
Tita AT, Szychowski JM, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes BL, Bell J, Aagaard K, Edwards RK, Gibson K, Haas DM, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade GR, Hoppe KK, Foroutan J, Tuuli M, Owens MY, Simhan HN, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy UM, Kinzler W, Su E, Krishna I, Nguyen N, Norton ME, Skupski D, El-Sayed YY, Ogunyemi D, Galis ZS, Harper L, Ambalavanan N, Geller NL, Oparil S, Cutter GR, Andrews WW, Chronic H, Pregnancy Trial C (2022) Treatment for mild chronic hypertension during pregnancy. N Engl J Med 386(19):1781–1792
Tooher J, Thornton C, Makris A, Ogle R, Korda A, Hennessy A (2017) All hypertensive disorders of pregnancy increase the risk of future cardiovascular disease. Hypertension 70(4):798–803
Toprak V, Kafadar MT (2021) Intrahepatic cholestasis of pregnancy: is fetoplacental doppler ultrasound useful in the diagnosis and follow-up? Ann Clin Anal Med 12(01):87–91
Townsend R, O’Brien P, Khalil A (2016) Current best practice in the management of hypertensive disorders in pregnancy. Integr Blood Press Control 9:79–94
Trauner M, Fickert P, Pertl B (2004) Schwangerschaftsspezifische Lebererkrankungen. Dtsch Arztebl 101(50):A3416–A3425
Trogstad L, Skrondal A, Stoltenberg C, Magnus P, Nesheim BI, Eskild A (2004) Recurrence risk of preeclampsia in twin and singleton pregnancies. Am J Med Genet A 126A(1):41–45
Trottmann F, Baumann M, Amylidi-Mohr S, Surbek D, Risch L, Mosimann B, Raio L (2019) Angiogenic profiling in HELLP syndrome cases with or without hypertension and proteinuria. Eur J Obstet Gynecol Reprod Biol 243:93–96
Tsiakkas A, Saiid Y, Wright A, Wright D, Nicolaides KH (2016) Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 30–34 weeks’ gestation. Am J Obstet Gynecol 215(1):87 e81–87 e17
Tucker KL, Bankhead C, Hodgkinson J, Roberts N, Stevens R, Heneghan C, Rey E, Lo C, Chandiramani M, Taylor RS, North RA, Khalil A, Marko K, Waugh J, Brown M, Crawford C, Taylor KS, Mackillop L, McManus RJ (2018) How do home and clinic blood pressure readings compare in pregnancy? Hypertension 72(3):686–694
Tuffnell DJ, Jankowicz D, Lindow SW, Lyons G, Mason GC, Russell IF, Walker JJ, Yorkshire Obstetric Critical Care, G (2005) Outcomes of severe pre-eclampsia/eclampsia in Yorkshire 1999/2003. BJOG 112(7):875–880
Turunen K, Molsa A, Helander K, Sumanen M, Mattila KJ (2012) Health history after intrahepatic cholestasis of pregnancy. Acta Obstet Gynecol Scand 91(6):679–685
Ukah UV, Payne B, Hutcheon JA, Ansermino JM, Ganzevoort W, Thangaratinam S, Magee LA, Von Dadelszen P (2018) Assessment of the fullPIERS risk prediction model in women with early-onset preeclampsia. Hypertension 71(4):659–665
Ukah UV, Payne B, Karjalainen H, Kortelainen E, Seed PT, Conti-Ramsden FI, Cao V, Laivuori H, Hutcheon J, Chappell L, Mark Ansermino J, Vatish M, Redman C, Lee T, Li L, Magee LA, Von Dadelszen P, Full PG (2019) Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia. Pregnancy Hypertens 15:42–50
Valensise H, Vasapollo B, Gagliardi G, Novelli GP (2008) Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 52(5):873–880
Van Esch JJA, Van Heijst AF, De Haan AFJ, Van der Heijden OWH (2017) Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med 30(23):2789–2794
Van Oostwaard MF, Langenveld J, Schuit E, Papatsonis DN, Brown MA, Byaruhanga RN, Bhattacharya S, Campbell DM, Chappell LC, Chiaffarino F, Crippa I, Facchinetti F, Ferrazzani S, Ferrazzi E, Figueiro-Filho EA, Gaugler-Senden IP, Haavaldsen C, Lykke JA, Mbah AK, Oliveira VM, Poston L, Redman CW, Salim R, Thilaganathan B, Vergani P, Zhang J, Steegers EA, Mol BW, Ganzevoort W (2015) Recurrence of hypertensive disorders of pregnancy: an individual patient data metaanalysis. Am J Obstet Gynecol 212(5):624. e621–617
Van Oostwaard MF, Van Eerden L, De Laat MW, Duvekot JJ, Erwich J, Bloemenkamp K, Bolte AC, Bosma J, Koenen SV, Kornelisse RF, Rethans B, Van Runnard Heimel P, Scheepers H, Ganzevoort W, Mol B, De Groot CJ, Gaugler-Senden I (2017) Maternal and neonatal outcomes in women with severe early onset pre-eclampsia before 26 weeks of gestation, a case series. BJOG 124(9):1440–1447
Van Rijn BB, Hoeks LB, Bots ML, Franx A, Bruinse HW (2006) Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia. Am J Obstet Gynecol 195(3):723–728
Vasapollo B, Lo Presti D, Gagliardi G, Farsetti D, Tiralongo GM, Pisani I, Novelli GP, Valensise H (2018) Restricted physical activity in pregnancy reduces maternal vascular resistance and improves fetal growth. Ultrasound Obstet Gynecol 51(5):672–676
Vatten LJ, Skjaerven R (2004) Is pre-eclampsia more than one disease? BJOG 111(4):298–302
Vaught AJ, Kovell LC, Szymanski LM, Mayer SA, Seifert SM, Vaidya D, Murphy JD, Argani C, O’Kelly A, York S, Ouyang P, Mukherjee M, Zakaria S (2018) Acute cardiac effects of severe pre-eclampsia. J Am Coll Cardiol 72(1):1–11
Vela Vásquez RS, Peláez Romero R (2015) Aspirin and spinal haematoma after neuraxial anaesthesia: myth or reality? Br J Anaesth 115(5):688–698
Verlohren S (2022a) Ätiologie und Pathogenese: Angiogene Faktoren. In: Stepan H, Verlohren S (Hrsg) Präeklampsie. De Gruyter, Berlin/Boston, S 83–98
Verlohren S (2022b) Screening. In: Stepan H, Verlohren S (Hrsg) Präeklampsie – Diagnostik und Klinisches Management. De Gruyter, Berlin/Boston
Vest AR, Cho LS (2014) Hypertension in pregnancy. Curr Atheroscler Rep 16(3):395
Vigil-De Gracia P, Ortega-Paz L (2012) Pre-eclampsia/eclampsia and hepatic rupture. Int J Gynaecol Obstet 118(3):186–189
Vigil-Degracia P, Ludmir J, Ng J, Reyes-Tejada O, Nova C, Beltre A, Yuen-Chon V, Collantes J, Turcios E, Lewis R, Cabrera S (2018) Is there benefit to continue magnesium sulphate postpartum in women receiving magnesium sulphate before delivery? A randomised controlled study. BJOG 125(10):1304–1311
Vinayagam D, Leslie K, Khalil A, Thilaganathan B (2015) Preeclampsia – what is to blame? The placenta, maternal cardiovascular system or both? World J Obstet Gynecol 4(4):77–85
Vischer AS, Burkard T (2017) Principles of blood pressure measurement – current techniques, office vs ambulatory blood pressure measurement. Adv Exp Med Biol 956:85–96
Visser W, Wallenburg HC (1995) Temporising management of severe pre-eclampsia with and without the HELLP syndrome. Br J Obstet Gynaecol 102(2):111–117
Vlemmix F, Warendorf JK, Rosman AN, Kok M, Mol BW, Morris JM, Nassar N (2013) Decision aids to improve informed decision-making in pregnancy care: a systematic review. BJOG 120(3):257–266
Walters BN (2011) Preeclamptic angina – a pathognomonic symptom of preeclampsia. Hypertens Pregnancy 30(2):117–124
Wang HY, Jiang Q, Shi H, Xu YQ, Shi AC, Sun YL, Li J, Ning Q, Shen GX (2016) Effect of caesarean section on maternal and foetal outcomes in acute fatty liver of pregnancy: a systematic review and meta-analysis. Sci Rep 6:28826
Waugh JJ, Clark TJ, Divakaran TG, Khan KS, Kilby MD (2004) Accuracy of urinalysis dipstick techniques in predicting significant proteinuria in pregnancy. Obstet Gynecol 103(4):769–777
Weiner CP (1987) Thrombotic microangiopathy in pregnancy and the postpartum period. Semin Hematol 24(2):119–129
Weinstein L (1982) Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142(2):159–167
Wertaschnigg D, Reddy M, Mol BWJ, Rolnik DL, Da Silva Costa F (2019) Prenatal screening for pre-eclampsia: frequently asked questions. Aust N Z J Obstet Gynaecol 59(4):477–483
Wicinski M, Malinowski B, Puk O, Socha M, Slupski M (2020) Methyldopa as an inductor of postpartum depression and maternal blues: a review. Biomed Pharmacother 127:110196
Wilke G, Rath W, Schutz E, Armstrong VW, Kuhn W (1992) Haptoglobin as a sensitive marker of hemolysis in HELLP-syndrome. Int J Gynaecol Obstet 39(1):29–34
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, De Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I, Group, E. S. C. S. D (2018) 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 39(33):3021–3104
Wiwanitkit V (2010) Periodic urinary protein creatinine ratio for predicting significant proteinuria in preeclampsia in different alternatives: time effectiveness analysis. Arch Gynecol Obstet 281(3):571–573
Woudstra DM, Chandra S, Hofmeyr GJ, Dowswell T (2010) Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. Cochrane Database Syst Rev 9:CD008148
Wright A, Wright D, Syngelaki A, Georgantis A, Nicolaides KH (2019) Two-stage screening for preterm preeclampsia at 11–13 weeks’ gestation. Am J Obstet Gynecol 220(2):197 e191–197 e111
Wright D, Akolekar R, Syngelaki A, Poon LC, Nicolaides KH (2012) A competing risks model in early screening for preeclampsia. Fetal Diagn Ther 32(3):171–178
Wright D, Syngelaki A, Akolekar R, Poon LC, Nicolaides KH (2015) Competing risks model in screening for preeclampsia by maternal characteristics and medical history. Am J Obstet Gynecol 213(1):62 e61–62 e10
Wright D, Poon LC, Rolnik DL, Syngelaki A, Delgado JL, Vojtassakova D, De Alvarado M, Kapeti E, Rehal A, Pazos A, Carbone IF, Dutemeyer V, Plasencia W, Papantoniou N, Nicolaides KH (2017) Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia. Am J Obstet Gynecol 217(6):685 e681–685 e685
Wright WL (2017) Neurologic complications in critically ill pregnant patients. Handb Clin Neurol 141:657–674
Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Umazume T, Itakura A, Maeda M, Sagawa N, Ohno Y, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Nakai A, Minakami H (2016) Isolated gestational proteinuria preceding the diagnosis of preeclampsia – an observational study. Acta Obstet Gynecol Scand 95(9):1048–1054
Yamasmit W, Chaithongwongwatthana S, Charoenvidhya D, Uerpairojkit B, Tolosa J (2004) Random urinary protein-to-creatinine ratio for prediction of significant proteinuria in women with preeclampsia. J Matern Fetal Neonatal Med 16(5):275–279
Ying W, Catov JM, Ouyang P (2018) Hypertensive disorders of pregnancy and future maternal cardiovascular risk. J Am Heart Assoc 7(17):e009382
Yoder SR, Thornburg LL, Bisognano JD (2009) Hypertension in pregnancy and women of childbearing age. Am J Med 122(10):890–895
Yoo KY, Kang DH, Jeong H, Jeong CW, Choi YY, Lee J (2013) A dose-response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia. Int J Obstet Anesth 22(1):10–18
Yoselevsky E, Mcelrath T, Little S (2022) Readmission for postpartum eclampsia in the United States. J Matern Fetal Neonatal Med 35:10082–10085
Yu CK, Smith GC, Papageorghiou AT, Cacho AM, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening, G (2005) An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk women. Am J Obstet Gynecol 193(2):429–436
Yu CK, Khouri O, Onwudiwe N, Spiliopoulos Y, Nicolaides KH, Fetal Medicine Foundation Second-Trimester Screening, G (2008) Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age. Ultrasound Obstet Gynecol 31(3):310–313
Zeeman GG (2009) Neurologic complications of pre-eclampsia. Semin Perinatol 33(3):166–172
Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstrom M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S (2016) Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med 374(1):13–22
Zhang J, Klebanoff MA, Roberts JM (2001) Prediction of adverse outcomes by common definitions of hypertension in pregnancy. Obstet Gynecol 97(2):261–267
Zhang J, Meikle S, Trumble A (2003) Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States. Hypertens Pregnancy 22(2):203–212
Zini G, De Cristofaro R (2019) Diagnostic testing for differential diagnosis in thrombotic microangiopathies. Turk J Haematol 36(4):222–229
Zwart JJ, Richters A, Ory F, De Vries JI, Bloemenkamp KW, Van Roosmalen J (2008) Eclampsia in the Netherlands. Obstet Gynecol 112(4):820–827
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Schlembach, D., Baumann, M., Kehl, S., Klaritsch, P., Lobmaier, S. (2023). Abnormale Plazentation: Hypertensive Schwangerschaftserkrankungen. In: von Kaisenberg, C., Klaritsch, P., Hösli-Krais, I. (eds) Die Geburtshilfe. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44369-9_18-2
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DOI: https://doi.org/10.1007/978-3-662-44369-9_18-2
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Abnormale Plazentation: Hypertensive Schwangerschaftserkrankungen- Published:
- 13 December 2023
DOI: https://doi.org/10.1007/978-3-662-44369-9_18-2
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Fetale Wachstumsrestriktion (FGR)- Published:
- 14 March 2015
DOI: https://doi.org/10.1007/978-3-662-44369-9_18-1