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Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers

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Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 63))

Abstract

Episodic memory research in schizophrenia has a long history already which has clearly established significant impairments and strong associations with brain measures and functional outcome. The purpose of this chapter is not to make an exhaustive review of the recent literature but to highlight some relatively recent developments in the cognitive neuroscience field of episodic memory and schizophrenia. Hence, we present a contemporary view focusing specifically of relational memory which represents a form of episodic memory that refers to associations or binding among items or elements presented together. We describe the major tasks used and illustrate how their combination with brain imaging has: (1) favored the use of experimental memory tasks to isolate specific processes with specific neural correlates, (2) led to a distributed view of the neural correlates of memory impairments in schizophrenia where multiple regions are contributing, and (3) made possible the identification of fMRI biomarkers specific to episodic memory. We then briefly propose what we see as the next steps for memory research in schizophrenia so that the impact of this work can be maximized.

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Authors and Affiliations

  1. Cognition, Health, and Society Laboratory (EA 6291), University of Reims Champagne-Ardenne, Reims, France

    Delphine Raucher-Chéné

  2. Academic Department of Psychiatry, University Hospital of Reims, EPSM Marne, Reims, France

    Delphine Raucher-Chéné

  3. Douglas Research Centre, Verdun, QC, Canada

    Katie M. Lavigne & Martin Lepage

  4. Department of Psychiatry, McGill University, Montréal, QC, Canada

    Katie M. Lavigne & Martin Lepage

  5. McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada

    Katie M. Lavigne

Authors
  1. Delphine Raucher-Chéné
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  2. Katie M. Lavigne
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  3. Martin Lepage
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Corresponding author

Correspondence to Martin Lepage .

Editor information

Editors and Affiliations

  1. Departments of Psychological and Brain Sciences, Psychiatry, and Radiology, Washington University, Saint Louis, MO, USA

    Deanna M. Barch

  2. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Jared W. Young

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© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Raucher-Chéné, D., Lavigne, K.M., Lepage, M. (2022). Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers. In: Barch, D.M., Young, J.W. (eds) Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework. Current Topics in Behavioral Neurosciences, vol 63. Springer, Cham. https://doi.org/10.1007/7854_2022_379

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