Summary
Molecular diagnostic adjuncts could improve the specificity of cervical cancer screening. Since persistent infection with human papillomavirus (HPV) is found in virtually 100% of cervical cancer cases, testing for markers of HPV integration may have a role in identifying underlying high-grade lesions in patients with low-grade cytologic abnormalities. Several proteins associated with the cell cycle are known to be affected by HPV integration into the host's DNA. Immunocytochemical identification of these upregu-lated proteins can assist in the identification of small numbers of pre-neoplastic or neoplastic cells in routine cytologic sampling.
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Dehn, D., Taylor, A., Fischer, T.J., Malinowski, D.P., Shroyer, K.R. (2009). Screening for Molecular Markers of Cervical Papillomavirus Infection: Overview of Methods and Their Clinical Implications. In: Kozlov, S.V. (eds) Inflammation and Cancer. Methods in Molecular Biology™, vol 511. Humana Press. https://doi.org/10.1007/978-1-59745-447-6_12
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DOI: https://doi.org/10.1007/978-1-59745-447-6_12
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