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Thromb Haemost 2011; 106(03): 561-562
DOI: 10.1160/TH11-04-0275
Letters to the Editor
Schattauer GmbH

Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells

Anke C. Rosenkranz
1   Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany
,
Karsten Schrör
1   Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany
,
Bernhard H. Rauch
2   Institut für Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald, Germany
› Author Affiliations
Further Information

Publication History

Received: 28 April 2011

Accepted after major revision: 15 June 2011

Publication Date:
24 November 2017 (online)

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  • References

  • 1 Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 2007; 27: 1687-1693.
    CrossrefPubMedGoogle Scholar
  • 2 Brummel KE, Paradis SG, Butenas S. et al. Thrombin functions during tissue factor-induced blood coagulation. Blood 2002; 100: 148-152.
    CrossrefPubMedGoogle Scholar
  • 3 Mutch NJ, Robbie LA, Booth NA. Human thrombi contain an abundance of active thrombin. Thromb Haemost 2001; 86: 1028-1034.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Schrör K, Bretschneider E, Fischer K. et al. Thrombin receptors in vascular smooth muscle cells – function and regulation by vasodilatory prostaglandins. Thromb Haemost 2010; 103: 884-890.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Bretschneider E, Braun M, Fischer A. et al. Factor Xa acts as a PDGF-independent mitogen in human vascular smooth muscle cells. Thromb Haemost 2000; 84: 499-505.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 McNamara CA, Sarembock IJ, Gimple LW. et al. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 1993; 91: 94-98.
    CrossrefPubMedGoogle Scholar
  • 7 Rauch BH, Millette E, Kenagy RD. et al. Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ Res 2004; 94: 340-345.
    CrossrefPubMedGoogle Scholar
  • 8 Koo BH, Chung KH, Hwang KC. et al. Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2. FEBS Lett 2002; 523: 85-89.
    CrossrefPubMedGoogle Scholar
  • 9 Hemker HC, Giesen P, Al Dieri R. et al. The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. Pathophysiol Haemost Thromb 2002; 32: 249-253.
    CrossrefPubMedGoogle Scholar
  • 10 Rosenkranz AC, Rauch BH, Freidel K. et al. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res 2009; 83: 778-784.
    CrossrefPubMedGoogle Scholar
  • 11 Rauch SJ, Rosenkranz AC, Böhm A. et al. Cholesterol induces apoptosis-associated loss of the activated leukocyte cell adhesion molecule (ALCAM) in human monocytes. Vascul Pharmacol 2011; 54: 93-99.
    CrossrefPubMedGoogle Scholar