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Am J Perinatol 1995; 12(6): 455-458
DOI: 10.1055/s-2007-994520
ORIGINAL ARTICLE

© 1995 by Thieme Medical Publishers, Inc.

In Utero Treatment of Fetal Goitrous Hypothyroidism Caused by Maternal Graves' Disease

Hamid A. Hadi, Diana Strickland
  • Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, East Carolina University School of Medicine, Greenville, North Carolina
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

We present two cases of maternal Graves' disease complicated by fetal goitrous hypothyroidism. Both patients had elevated maternal thyroid-stimulating immunoglobulin and thyrotropic-binding inhibitory immunoglobulin antibody titers. Diagnosis of fetal hypothyroidism was made by cordocentesis, and serial injections of thyroxine into the amniotic fluid resulted in return to normal of fetal thyroid size and function at birth. Significance of in utero management of fetal hypothyroidism is discussed.

Keywords

Graves' - disease - fetal goitrous hypothyroidism - thyroxine - cardocentesis

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