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Nuklearmedizin 1994; 33(06): 239-243
DOI: 10.1055/s-0038-1629709
Original Article
Schattauer GmbH

Evaluation of Cerebral Vasoreactivity by SPECT and Transcranial Doppler Sonography using the Acetazolamide Test

L. Pàvics
1   From the Departments of Nuclear Medicine and Bonn, FRG
,
F. Grünwald
4   Department of Nuclear Medicine, University, Bonn, FRG
,
P. Barzó
2   Neurosurgery, Albert Szent-Györgyi Medical University, the Bonn, FRG
,
E. Ambrus
1   From the Departments of Nuclear Medicine and Bonn, FRG
,
C. Menzel
4   Department of Nuclear Medicine, University, Bonn, FRG
,
A. Schomburg
4   Department of Nuclear Medicine, University, Bonn, FRG
,
L. Borda
2   Neurosurgery, Albert Szent-Györgyi Medical University, the Bonn, FRG
,
E. Máté
3   László Kalmár Kibernetic Laboratory, Attila József University, Szeged, Hungary, and the Bonn, FRG
,
L. Bodosi
2   Neurosurgery, Albert Szent-Györgyi Medical University, the Bonn, FRG
,
L. Csernay
1   From the Departments of Nuclear Medicine and Bonn, FRG
,
H. J. Biersack
4   Department of Nuclear Medicine, University, Bonn, FRG
› Author Affiliations
Further Information

Publication History

Received: 20 June 1994

in revised form: 04 August 1994

Publication Date:
04 February 2018 (online)

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Zusammenfassung

Bei 29 Patienten (3 Kontrollpersonen, 26 Patienten mit zerebrovaskulärer Erkrankung) wurde prospektiv die Hirn-SPECT mit 99mTC-HMPAO und bei 20 Patienten (3 Kontrollpersonen, 17 Patienten mit ZVK) die transkranielle Dopplersonographie (TCD) vor und nach i. v. Gabe von Azetazolamid durchgeführt. Die Sensitivität der Hirn-SPECT erhöhte sich mit Azetazolamid von 62% auf 77%. Bei Patienten mit reversiblem neurologischem Defizit wurde eine Verbesserung von 50% auf 71 %, bei Patienten mit persistierendem Defizit von 75% auf 83% beobachtet. Die Ergebnisse der Hirn-SPECT und der TCD stimmten in der Beurteilung der zerebro-vaskulären Reservekapazität in 91% der Hemisphären überein. Die Korrelation zwischen den beiden Methoden war statistisch signifikant.

Summary

rCBF SPECT with 99mTc-HMPAO was performed prospectively in 29 patients (3 controls and 26 stroke patients) as well as TCD studies in 20 patients (3 controls and 17 stroke patients) before and after 1 g i. v. acetazolamide. The sensitivity of rCBF SPECT increased from 62% to 77% after acetazolamide provocation in stroke patients. In patients with a reversible neurological deficit, the sensitivity under resting conditions was 50% which increased to 71%, while in cases with a permanent deficit it increased from 75% to 83%. In the evaluation of the cerebrovascular reserve capacity the results of rCBF SPECT and TCD coincided in 91 % of the hemispheres. The correlation was statistically significant.

Schlüsselwörter

Azetazolamid - zerebrovaskuläre Erkrankungen - SPECT - Ultraschall

Key words

Acetazolamide - cerebrovascular disorders - SPECT - ultrasonics
 

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