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Thromb Haemost 2002; 88(03): 387-388
DOI: 10.1055/s-0037-1613227
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Schattauer GmbH

Venous Thrombosis Following the Use of Intermediate Purity FVIII Concentrate to Treat Patients with Von Willebrand’s Disease

M. Makris
1   Sheffield Haemophilia and Thrombosis Cetre
,
B. Colvin
2   The Royal London Hospital Comprehensive Hamophilia Centre
,
V. Gupta
2   The Royal London Hospital Comprehensive Hamophilia Centre
,
M. L. Shields
3   Hull Royal Infirmary Haemophilia Centre
,
M. P. Smith
4   St Thomas’ Hospital Comprehensive Haemophilia Centre, London, U.K
› Author Affiliations
Further Information

Publication History

Received 20 April 2002

Accepted after revision 20 June 2002

Publication Date:
08 December 2017 (online)

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Summary

We describe four patients with von Willebrand’s disease (VWD) who experienced venous thrombosis after treatment with an intermediate purity factor VIII (FVIII) concentrate (Haemate P®) was used to cover invasive or surgical procedures. Most patients had additional risk factors for venous thromboembolism (VTE) and it is difficult to be certain of the contribution of the concentrate to the VTE. In view of the recognised association between high factor VIII activity (FVIII:C) levels and VTE there is a physiological basis for this complication and it is important to consider this when administering FVIII containing concentrates to VWD patients.

Keywords

Thrombosis - concentrate - VWD
 

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