Treatment of Diabetic Foot Ulcers using Mepilex Lite Dressings: A Pilot Study

 

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Abstract

Background:

5–10% diabetes patients will develop diabetic foot ulceration at some time during the life. The purpose of this study was to compare the effectiveness of Mepilex Lite dressings and vaseline gauze care in the healing of foot ulcers in diabetic patients.

Methods:

This was a randomized controlled trial, and a sample of 50 diabetic patients who had developed foot ulcers was assessed. Comparisons were made regarding parameters related to wound healing, including healing time and wound pain, and also regarding the adverse events.

Results:

The results showed that foot ulcers in the study group (Mepilex Lite, 24 patients) healed in a median of 49.9 days, which was significantly different from the healing time in the control group (median, 65.5 days, 26 patients; P=0.038). No statistically significant differences were detected between the 2 groups with pain. However, Mepilex Lite dressings significantly reduced wound area (P<0.05).

Conclusions:

The researchers conclude that Mepilex Lite dressing provides a promising alternative to diabetic foot ulcers and is worthy of further research.

• References

• 1 Mason J, O’Keeffe C, Hutchinson A et al. A systematic review of foot ulcer in patients with type 2 diabetes mellitus. Ii: Treatment. Diabetic medicine 1999; 16: 889-909
  CrossrefPubMedGoogle Scholar
• 2 New J, McDowell D, Burns E et al. Problem of amputations in patients with newly diagnosed diabetes mellitus. Diabetic medicine 1998; 15: 760-764
  CrossrefPubMedGoogle Scholar
• 3 Boulton AJ, Vileikyte L, Ragnarson-Tennvall G et al. The global burden of diabetic foot disease. The Lancet 2005; 366: 1719-1724
  CrossrefPubMedGoogle Scholar
• 4 ONFERENCEREPORT C . Consensus development conference on diabetic foot wound care. Diabetes Care 1999; 22: 1355
  PubMedGoogle Scholar
• 5 Steed DL, Attinger C, Colaizzi T et al. Guidelines for the treatment of diabetic ulcers. Wound repair and regeneration 2006; 14: 680-692
  CrossrefPubMedGoogle Scholar
• 6 White R. Evidence for atraumatic soft silicone wound dressing use. Wounds uK 2005; 1: 104-109
  PubMedGoogle Scholar
• 7 Kennedy-Evans KL. An innovative solution for skin tears: A case study. Ostomy/wound management 2004; 50: 9
  PubMedGoogle Scholar
• 8 Lipsky BA, Berendt AR, Deery HG et al. Diagnosis and treatment of diabetic foot infections. Clinical Infectious Diseases 2004; 39: 885-910
  CrossrefPubMedGoogle Scholar
• 9 Carlsson AM. Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Pain 1983; 16: 87-101
  CrossrefPubMedGoogle Scholar
• 10 Melzack R. The short-form mcgill pain questionnaire. Pain 1987; 30: 191-197
  CrossrefPubMedGoogle Scholar
• 11 van Schie CM. A review of the biomechanics of the diabetic foot. The international journal of lower extremity wounds 2005; 4: 160-170
  CrossrefPubMedGoogle Scholar
• 12 Reiber GE, Vileikyte L, Boyko Ed et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999; 22: 157-162
  CrossrefPubMedGoogle Scholar
• 13 Armstrong DG, Athanasiou KA. The edge effect: How and why wounds grow in size and depth. Clinics in podiatric medicine and surgery 1998; 15: 105
  PubMedGoogle Scholar
• 14 Armstrong DG, Lavery LA. Diabetic foot ulcers: Prevention, diagnosis and classification. American family physician 1998; 57: 1325-1332 1337–1338
  PubMedGoogle Scholar
• 15 Armstrong DG, Lavery LA, Nixon BP et al. It’s not what you put on, but what you take off: Techniques for debriding and off-loading the diabetic foot wound. Clinical Infectious Diseases 2004; 39: S92-S99
  CrossrefPubMedGoogle Scholar
• 16 Armstrong DG, Lavery LA, Vazquez JR et al. How and why to surgically debride neuropathic diabetic foot wounds. Journal of the American Podiatric Medical Association 2002; 92: 402-404
  CrossrefPubMedGoogle Scholar
• 17 Abbott CA, Vileikyte L, Williamson S et al. Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration. Diabetes Care 1998; 21: 1071-1075
  CrossrefPubMedGoogle Scholar
• 18 Apelqvist J, Larsson J. What is the most effective way to reduce incidence of amputation in the diabetic foot?. Diabetes/metabolism research and reviews 2000; 16: S75-S83
  CrossrefPubMedGoogle Scholar
• 19 Seaman S. Dressing selection in chronic wound management. Journal of the American Podiatric Medical Association 2002; 92: 24-33
  CrossrefPubMedGoogle Scholar
• 20 Veves A, Falanga V, Armstrong DG et al. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers a prospective randomized multicenter clinical trial. Diabetes Care 2001; 24: 290-295
  CrossrefPubMedGoogle Scholar