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Horm Metab Res 2013; 45(09): 655-659
DOI: 10.1055/s-0033-1345151
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Leptin Administration on Mammary Tumor Growth in Diabetic Mice

K. Bitton-Worms
1   Diabetes and Metabolism Clinical Research Center of Excellence, Clinical Research Institute at Rambam (CRIR) and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
,
R. Rostoker
1   Diabetes and Metabolism Clinical Research Center of Excellence, Clinical Research Institute at Rambam (CRIR) and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
,
S. Braun
1   Diabetes and Metabolism Clinical Research Center of Excellence, Clinical Research Institute at Rambam (CRIR) and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
,
Z. Shen-Orr
1   Diabetes and Metabolism Clinical Research Center of Excellence, Clinical Research Institute at Rambam (CRIR) and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
,
D. LeRoith
1   Diabetes and Metabolism Clinical Research Center of Excellence, Clinical Research Institute at Rambam (CRIR) and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
› Author Affiliations
Further Information

Publication History

received 06 February 2013

accepted 18 April 2013

Publication Date:
22 May 2013 (online)

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Abstract

Obesity is associated with hyperleptinemia and this has led to the suggestion that leptin maybe a factor in cancer progression. To study the effect of leptin on cancer progression we used a mouse model of diabetes that was shown to enhance tumor progression and thereby determine if leptin affects cancer progression despite improvements in metabolic status. Mammary tumors were allowed to develop in male and female mice following orthotopic injection of cells expressing oncogenes. After 2 weeks leptin was administered to the mice using Alzet pumps. In these mice leptin failed to stimulate tumor progression; indeed, in those studies where glucose tolerance improved tumor growth was actually inhibited. Thus, the possibility exists that the effect of leptin on tumor progression maybe opposed by improvements in metabolism.

Key words

cancer - leptin - metabolism
 

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