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Exp Clin Endocrinol Diabetes 2012; 120(08): 466-468
DOI: 10.1055/s-0032-1306298
Short Communication
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population

I. Kalnina
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
,
K. Geldnere
2   Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia
,
L. Tarasova
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
,
L. Nikitina-Zake
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
,
R. Peculis
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
,
D. Fridmanis
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
,
V. Pirags   *
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
2   Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia
3   Faculty of Medicine, University of Latvia, Riga, Latvia
,
J. Klovins   *
1   Latvian Biomedical Research and Study Centre, Riga, Latvia
› Author Affiliations
Further Information

Publication History

received 10 January 2012
first decision 14 February 2012

accepted 17 February 2012

Publication Date:
22 March 2012 (online)

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Abstract

Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for type 2 diabetes (T2D) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. We genotyped 4 single nucleotide polymorphisms (SNP) rs7901695, rs7903146, rs11196205 and rs12255372 in 1 093 controls and 1 043 diabetic subjects. Association with T2D was found for 3 SNPs rs7901695, rs7903146 and rs12255372 in the whole sample (under an additive genetic model, the adjusted odds ratios (OR) were 1.26, 95% CI [1.08–1.48], P=0.003; OR=1.32, 95% CI [1.12–1.55], P=0.001 and OR=1.35, 95% CI [1.15–1.60], P=0.0004 respectively). In addition observed effects on T2D susceptibility for analysed SNPs were higher among subjects with BMI under 30 kg/m2. The impact of TCF7L2 variation on T2D risk in Latvian population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.

Key words

association study - polymorphism - T2D
*

* Both authors contributed equally.


 

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