Pneumologie 2011; 65(1): 25-36
DOI: 10.1055/s-0030-1255783
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© Georg Thieme Verlag KG Stuttgart · New York

Sauerstoff in der Medizin

Oxygen in MedicineD.  Köhler1 , P.  Haidl1
  • 1Fachkrankenhaus Kloster Grafschaft GmbH, Schmallenberg
Further Information

Publication History

Publication Date:
17 January 2011 (online)

Lernziele

Kenntnisse über

die Nutzen und Gefahren einer Sauerstofftherapie bei akuter Hypoxämie, schwerer Hypoxämie auf der Intensivstation, chronischer Hypoxämie und Hypoxämie unter Belastung.

  • 1 Zander R. Der pulmonale Sauerstoff-Speicher – Physiologie und klinischer Nutzen.  Anästhesiol Intensivmed Notfallmed Schmerzther. 2002;  37 34-38
  • 2 Richmond K N, Burnite S, Lynch R M. Oxygen sensitivity of mitochondrial metabolic state in isolated skeletal and cardiac myocytes.  Am J Physiol. 1997;  273 C1613-C1622
  • 3 Timms R M, Tisi G M. The effect of short-term oxygen supplementation on oxygen hemoglobin affinity in patients with chronic obstructive pulmonary disease.  Am Rev Respir Dis. 1985;  131 69-72
  • 4 Howald H, Pette D, Simoneau J A et al. Effect of chronic hypoxia on muscle enzyme activities.  Int J Sports Med.. 1990;  11 Suppl 1 S10-S14
  • 5 Terrados N, Jansson E, Sylvén C et al. Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin?.  J Appl Physiol. 1990;  68 2369-2372
  • 6 Köhler D. Wieviel Hypoxämie verträgt der Mensch.  Dtsch Med Wochenschr. 2010;  135 474-477
  • 7 Köhler D. CaO2-Wert zur Beurteilung der Sauerstoff-Organversorgung: Klinische Bedeutung des Sauerstoffgehaltes.  Dtsch Ärzteblatt. 2005;  102 2026-2030
  • 8 Schönhofer B, Böhrer H, Köhler D. Blood transfusion facilitating difficult weaning from the ventilator.  Anaesthesia. 1998;  53 181-184
  • 9 Schönhofer B, Wenzel M, Geibel M et al. Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease.  Crit Care Med. 1998;  26 1824-1828
  • 10 Köhler D. Analogien zwischen Herz- und Atemmuskelinsuffizienz – Bedeutung in der Klinik.  Dtsch Med Wochenschr. 2009;  134 147-153
  • 11 Beattie W S, Karkouti K, Wijeysundera D N et al. Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study.  Anesthesiology.. 2009;  110 574-581
  • 12 De Santo L, Romano G, Della Corte A et al. Preoperative anemia in patients undergoing coronary artery bypass grafting predicts acute kidney injury.  J Thorac Cardiovasc Surg. 2009;  138 965-970
  • 13 Wu W C, Rathore S S, Wang Y et al. Blood transfusion in elderly patients with acute myocardial infarction.  N Engl J Med.. 2001;  345 1230-1236
  • 14 Schönhofer B, Köhler D. Hyperkapnie.  Intensivmedizin. 1997;  34 510-512
  • 15 S2-Leitlinie (AWMF): Prävention, Diagnose, Therapie und Nachsorge der Sepsis. www.uni-duesseldorf.de/AWMF/ll/079-001.htm Stand: 2005
  • 16 Wirtz H R, Dobbs L G. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells.  Science. 1990;  30; 250 1266-1269
  • 17 Hegeman M A, Hennus M P, Heijnen C J et al. Ventilator-induced endothelial activation and inflammation in the lung and distal organs.  Crit Care. 2009;  13 R182
  • 18 Zenri H, Rodriquez-Capote K, McCaig L et al. Hyperoxia exposure impairs surfactant function and metabolism.  Crit Care Med. 2004;  32 1155-1160
  • 19 Altemeier W A, Sinclair S E. Hyperoxia in the intensive care unit: why more is not always better.  Curr Opin Crit Care. 2007;  13 73-78
  • 20 Rothen H U, Sporre B, Engberg G et al. Prevention of atelectasis during general anaesthesia.  Lancet. 1995;  345 1387-1391
  • 21 Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party.  Lancet. 1981;  28 81-86
  • 22 Nocturnal Oxygen Therapy Trial Group . Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial.  Ann Intern Med. 1980;  93 391-398
  • 23 Magnussen H, Kirsten A M, Köhler D Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin e. V. et al.. Leitlinie Langzeit-Sauerstofftherapie.  Pneumologie. 2008;  62 748-756
  • 24 Ringbaek T J. Home oxygen therapy in COPD patients. Results from the Danish Oxygen Register 1994 – 2000.  Dan Med Bull. 2006;  53 310-325
  • 25 Chailleux E, Fauroux B, Binet F et al. Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation. A 10-year analysis of ANTADIR Observatory.  Chest. 1996;  109 741-749
  • 26 Aida A, Miyamoto K, Nishimura M et al. Prognostic value of hypercapnia in patients with chronic respiratory failure during long-term oxygen therapy.  Am J Respir Crit Care Med. 1998;  158 188-193
  • 27 Oswald-Mammosser M, Weitzenblum E, Quoix E et al. Prognostic factors in COPD patients receiving long-term oxygen therapy. Importance of pulmonary artery pressure.  Chest. 1995;  107 1193-1198
  • 28 Zieliński J, Tobiasz M, Hawryłkiewicz I et al. Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients: a 6-year prospective study.  Chest. 1998;  113 65-70
  • 29 Okubadejo A A, Paul E A, Jones P W et al. Does long-term oxygen therapy affect quality of life in patients with chronic obstructive pulmonary disease and severe hypoxaemia?.  Eur Respir J. 1996;  9 2335-2339
  • 30 Eaton T, Lewis C, Young P et al. Long-term oxygen therapy improves health-related quality of life.  Respir Med. 2004;  98 285-293
  • 31 Lacasse Y, Lecours R, Pelletier C et al. Randomised trial of ambulatory oxygen in oxygen-dependent COPD.  Eur Respir J. 2005;  25 1032-1038
  • 32 Nonoyama M L, Brooks D, Guyatt G H et al. Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia.  Am J Respir Crit Care Med. 2007;  176 343-349
  • 33 Górecka D, Gorzelak K, Sliwiński P et al. Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia.  Thorax. 1997;  52 674-679
  • 34 Haidl P, Clement C, Wiese C et al. Long-term oxygen therapy stops the natural decline of endurance in COPD patients with reversible hypercapnia.  Respiration. 2004;  71 342-347
  • 35 Garcia-Aymerich J, Serra I, Gómez F P. et al. Phenotype and Course of COPD Study Group . Physical activity and clinical and functional status in COPD.  Chest. 2009;  136 62-70
  • 36 Ringbaek T J, Viskum K, Lange P. Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease?.  Eur Respir J. 2002;  20 38-42
  • 37 Penaloza D, Arias-Stella J. The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness.  Circulation. 2007;  115 1132-1146
  • 38 Stolz D, Rasch H, Linka A et al. A randomised, controlled trial of bosentan in severe COPD.  Eur Respir J. 2008;  32 619-628
  • 39 Schönhofer B, Barchfeld T, Wenzel M et al. Long term effects of non-invasive mechanical ventilation on pulmonary haemodynamics in patients with chronic respiratory failure.  Thorax. 2001;  56 524-528
  • 40 Zielinski J, MacNee W, Wedzicha J et al. Causes of death in patients with COPD and chronic respiratory failure.  Monaldi Arch Chest Dis. 1997;  52 43-47
  • 41 Ekström M, Franklin K A, Ström K E. Increased relative mortality in women with severe oxygen-dependent COPD.  Chest. 2010;  137 31-36
  • 42 Leach R M, Davidson A C, Chinn S et al. Portable liquid oxygen and exercise ability in severe respiratory disability.  Thorax. 1992;  47 781-789
  • 43 Deneke S M, Fanburg B L. Normobaric oxygen toxicity of the lung.  N Engl J Med. 1980;  303 76-86
  • 44 Laudert S, Thibeault D W, Rezaiekhaligh M M et al. Comparative age-related acute and chronic pulmonary oxygen tolerance in rats.  J Appl Physiol. 1994;  77 2709-2719
  • 45 Garner W L, Downs J B, Reilley T E et al. The effects of hyperoxia during fulminant sepsis.  Surgery. 1989;  105 747-751
  • 46 Jackson R M. Pulmonary oxygen toxicity.  Chest. 1985;  88 900-905
  • 47 Altemeier W A, Sinclair S E. Hyperoxia in the intensive care unit: why more is not always better.  Curr Opin Crit Care. 2007;  13 73-78
  • 48 Köhler D, Vastag E. Bronchiale Clearance.  Pneumologie. 1991;  45 314-1032
  • 49 Tryka A F, Skornik W A, Godleski J J et al. Potentiation of bleomycin-induced lung injury by exposure to 70 % oxygen. Morphologic assessment.  Am Rev Respir Dis. 1982;  126 1074-1079
  • 50 Giri S N, Hyde D M. Increases in severity of lung damage and mortality by treatment with cyclo and lipoxygenase inhibitors in bleomycin and hyperoxia model of lung injury in hamsters.  Pathology. 1987;  19 150-158
  • 51 Spector J I, Zimbler H, Ross J S. Cyclophosphamide and interstitial pneumonitis.  JAMA. 1980;  21;243 1133
  • 52 Travis E L, De Luca A M. The effect of breathing 100 % oxygen on lung response to radiation in mice.  Radiother Oncol. 1985;  3 177-179
  • 53 Wood D L, Osborn M J, Rooke J et al. Amiodarone pulmonary toxicity: report of two cases associated with rapidly progressive fatal adult respiratory distress syndrome after pulmonary angiography.  Mayo Clin Proc. 1985;  60 601-603
  • 54 Sakamoto S, Homma S, Kawabata M et al. Fatal acute exacerbation of idiopathic pulmonary fibrosis/usual interstitial pneumonia initially in the right lung after surgery lobectomy for left lung cancer.  Nihon Kokyuki Gakkai Zasshi. 2004;  42 760-766
  • 55 Hyzy R, Huang S, Myers J et al. Acute exacerbation of idiopathic pulmonary fibrosis.  Chest. 2007;  132 1652-1658

Prof. Dr. med. Dieter Köhler

Fachkrankenhaus Kloster Grafschaft GmbH

Annostr. 1
57392 Schmallenberg

Email: d.koehler@fkkg.de

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