Three Major Metabolites of Mulberroside A in Rat Intestinal Contents and Feces

 

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Abstract

Mulberroside A, a major stilbene constituent of Morus alba L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2-O-β-D-glucopyranoside (1), oxyresveratrol-3′-O-β-D-glucopyranoside (2), and oxyresveratrol (3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.

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1 These authors contributed equally to this work.

Prof. Feng Qiu

Department of Natural Products Chemistry
Shenyang Pharmaceutical University

103 Wenhua Road

Shenyang 110016

Liaoning

People's Republic of China

Phone: + 86 24 23 98 64 63

Fax: + 86 24 23 99 39 94

Email: fengqiu2000@tom.com

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