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Klin Monbl Augenheilkd 2024; 241(04): 500-505
DOI: 10.1055/a-2237-2943
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Intra-arterial Chemotherapy for Retinoblastoma: 15-Year Experience

Intraarterielle Chemotherapie für Retinoblastom: 15 Jahre Erfahrung
Christina Stathopoulos
1   Ocular Oncology Department, Jules-Gonin Eye Hospital, Lausanne, Switzerland
,
Guillaume Saliou
2   Interventional Neuroradiology Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
,
Alexandre Moulin
3   Eye Pathology, Jules-Gonin Eye Hospital, Lausanne, Switzerland
,
Maja Beck-Popovic
4   Unit of Pediatric Hematology-Oncology, CHUV, Lausanne, Switzerland
,
Francis Munier
5   Ophthalmology, Jules-Gonin Eye Hospital, Lausanne, Switzerland
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Introduction

Since its introduction in 2008, intra-arterial chemotherapy (IAC) has significantly improved the conservative (eye preserving) management of retinoblastoma (rb), allowing not only the salvage of eyes that would otherwise face enucleation, but also, together with intravitreal chemotherapy, to eradicate the need for external beam irradiation [1]. The success of IAC lies in the achievement of high-dose concentrations of chemotherapy agents directly into the blood vessels that supply the eye, while reducing systemic exposure and complications of intravenous chemotherapy (IVC) such as hospitalizations, port placement, and frequent need for transfusions [2], [3].



Publication History

Received: 01 November 2023

Accepted: 18 December 2023

Article published online:
23 April 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 Abramson DH, Shields CL, Munier FL. et al. Treatment of Retinoblastoma in 2015: Agreement and Disagreement. JAMA Ophthalmol 2015; 133: 1341-1347
    CrossrefPubMedGoogle Scholar
  • 2 Wyse E, Handa JT, Friedman AD. et al. A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol 2016; 46: 1223-1233
    CrossrefPubMedGoogle Scholar
  • 3 Shields CL, Lally SE, Leahey AM. et al. Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy. Curr Opin Ophthalmol 2014; 25: 374-385
    CrossrefPubMedGoogle Scholar
  • 4 Kaneko A, Suzuki S. Eye-preservation treatment of retinoblastoma with vitreous seeding. Jpn J Clin Oncol 2003; 33: 601-607
    CrossrefPubMedGoogle Scholar
  • 5 Abramson DH, Dunkel IJ, Brodie SE. et al. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results. Ophthalmology 2008; 115: 1398-1404 1404.e1
    CrossrefPubMedGoogle Scholar
  • 6 Klufas MA, Gobin YP, Marr B. et al. Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. AJNR Am J Neuroradiol 2012; 33: 1608-1614
    CrossrefPubMedGoogle Scholar
  • 7 Akkari FG, Stathopoulos C, Puccinelli F. et al. Absorbable gelatin compressed sponge (Gelfoam) embolization of distal external carotid artery branches in intra-arterial chemotherapy for retinoblastoma. J Neurointerv Surg 2023; DOI: 10.1136/jnis-2023-020206.
    CrossrefPubMedGoogle Scholar
  • 8 Munier FL, Beck-Popovic M, Chantada GL. et al. Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”. Prog Retin Eye Res 2019; 73: 100764
    CrossrefPubMedGoogle Scholar
  • 9 Stathopoulos C, Bartolini B, Marie G. et al. Risk Factors for Acute Choroidal Ischemia after Intra-arterial Melphalan for Retinoblastoma: The Role of the Catheterization Approach. Ophthalmology 2021; 128: 754-764
    CrossrefPubMedGoogle Scholar
  • 10 Linn Murphree A. Intraocular retinoblastoma: the case for a new group classification. Ophthalmol Clin North Am 2005; 18: 41-53 viii
    CrossrefPubMedGoogle Scholar
  • 11 Abramson DH, Shields CL, Jabbour P. et al. Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide. Int J Retina Vitreous 2017; 3: 40
    CrossrefPubMedGoogle Scholar
  • 12 Chen Q, Zhang B, Dong Y. et al. Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis. BMC Cancer 2018; 18: 486
    CrossrefPubMedGoogle Scholar
  • 13 Munier FL, Mosimann P, Puccinelli F. et al. First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment. Br J Ophthalmol 2017; 101: 1086-1093
    CrossrefPubMedGoogle Scholar
  • 14 Gobin YP, Dunkel IJ, Marr BP. et al. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol 2011; 129: 732-737
    CrossrefPubMedGoogle Scholar
  • 15 Shields CL, Manjandavida FP, Lally SE. et al. Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma. Ophthalmology 2014; 121: 1453-1460
    CrossrefPubMedGoogle Scholar
  • 16 Abramson DH, Daniels AB, Marr BP. et al. Intra-Arterial Chemotherapy (Ophthalmic Artery Chemosurgery) for Group D Retinoblastoma. PLoS One 2016; 11: e0146582
    CrossrefPubMedGoogle Scholar
  • 17 Tuncer S, Sencer S, Kebudi R. et al. Superselective intra-arterial chemotherapy in the primary management of advanced intra-ocular retinoblastoma: first 4-year experience from a single institution in Turkey. Acta Ophthalmol 2016; 94: e644-e651
    CrossrefPubMedGoogle Scholar
  • 18 Munier FL, Moulin A, Gaillard MC. et al. Intracameral Chemotherapy for Globe Salvage in Retinoblastoma with Secondary Anterior Chamber Invasion. Ophthalmology 2018; 125: 615-617
    CrossrefPubMedGoogle Scholar
  • 19 Stathopoulos C, Gaillard MC, Puccinelli F. et al. Successful conservative treatment of massive choroidal relapse in 2 retinoblastoma patients monitored by ultrasound biomicroscopy and/or spectral domain optic coherence tomography. Ophthalmic Genet 2018; 39: 242-246
    CrossrefPubMedGoogle Scholar
  • 20 Feng ZX, Zhao J, Zhang N. et al. Adjuvant Chemotherapy Improves Survival for Children with Massive Choroidal Invasion of Retinoblastoma. Invest Ophthalmol Vis Sci 2023; 64: 27
    CrossrefPubMedGoogle Scholar
  • 21 Stathopoulos C, Lumbroso-Le Rouic L, Moll AC. et al. Current Indications of Secondary Enucleation in Retinoblastoma Management: A Position Paper on Behalf of the European Retinoblastoma Group (EURbG). Cancers (Basel) 2021; 13: 3392
    CrossrefPubMedGoogle Scholar
  • 22 Francis JH, Levin AM, Zabor EC. et al. Ten-year experience with ophthalmic artery chemosurgery: Ocular and recurrence-free survival. PLoS One 2018; 13: e0197081
    CrossrefPubMedGoogle Scholar
  • 23 Shields CL, Say EA, Pointdujour-Lim R. et al. Rescue intra-arterial chemotherapy following retinoblastoma recurrence after initial intra-arterial chemotherapy. J Fr Ophtalmol 2015; 38: 542-549
    CrossrefPubMedGoogle Scholar
  • 24 Francis JH, Abramson DH, Gobin YP. et al. Efficacy and toxicity of second-course ophthalmic artery chemosurgery for retinoblastoma. Ophthalmology 2015; 122: 1016-1022
    CrossrefPubMedGoogle Scholar
  • 25 De la Huerta I, Seider MI, Hetts SW. et al. Delayed Cerebral Infarction Following Intra-arterial Chemotherapy for Retinoblastoma. JAMA Ophthalmol 2016; 134: 712-714
    CrossrefPubMedGoogle Scholar
  • 26 Leal-Leal CA, Asencio-Lopez L, Higuera-Calleja J. et al. Globe Salvage With Intra-Arterial Topotecan-Melphalan Chemotherapy in Children With a Single Eye. Rev Invest Clin 2016; 68: 137-142
    PubMedGoogle Scholar
  • 27 Rojanaporn D, Chanthanaphak E, Boonyaopas R. et al. Intra-Arterial Chemotherapy for Retinoblastoma: 8-Year Experience from a Tertiary Referral Institute in Thailand. Asia Pac J Ophthalmol (Phila) 2019; 8: 211-217
    PubMedGoogle Scholar
  • 28 Ammanuel S, Alexander MD, Damato B. et al. Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma. Interv Neuroradiol 2018; 24: 345-350
    CrossrefPubMedGoogle Scholar
  • 29 Dalvin LA, Ancona-Lezama D, Lucio-Alvarez JA. et al. Ophthalmic Vascular Events after Primary Unilateral Intra-arterial Chemotherapy for Retinoblastoma in Early and Recent Eras. Ophthalmology 2018; 125: 1803-1811
    CrossrefPubMedGoogle Scholar
  • 30 Shields CL, Say EAT, Pefkianaki M. et al. Rhegmatogenous Retinal Detachment after Intraarterial Chemotherapy for Retinoblastoma: The 2016 Founders Award Lecture. Retina 2017; 37: 1441-1450
    CrossrefPubMedGoogle Scholar
  • 31 Stathopoulos C, Gaillard MC, Moulin A. et al. Intravitreal Anti-Vascular Endothelial Growth Factor for The Management of Neovascularization in Retinoblastoma after Intravenous and/or Intraarterial Chemotherapy: Long-Term Outcomes in a Series of 35 Eyes. Retina 2019; 39: 2273-2282
    CrossrefPubMedGoogle Scholar
  • 32 Busch MA, Haase A, Alefeld E. et al. Trefoil Family Factor Peptide 1-A New Biomarker in Liquid Biopsies of Retinoblastoma under Therapy. Cancers (Basel) 2023; 15: 4828
    CrossrefPubMedGoogle Scholar