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Omentum for Mammary Disorders: A 30-Year Systematic Review

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Although the safety of applying omentum to the female breast for total breast reconstruction is controversial, it has recently been used to treat certain mammary disorders as well. A systematic review was therefore conducted to analyze and establish the suitability and safety of applying omentum to the breast.

Methods

Covereing the interval from January 1984 to December 2013, we performed searches in MEDLINE, Embase, SciELO, and Google-Scholar for original articles describing the applicability of greater omentum to the breast and its clinical complications.

Results

Sixty observational articles with 985 women were chosen. The main clinical indications were total breast reconstruction after mastectomy due to breast cancer (45 studies), radiation damage (23 studies), and congenital Poland syndrome (4 studies). Altogether, 273 complications were identified among the 985 women treated. The most frequent was flap necrosis (26.74 %). The most serious was injury to the digestive system (1.10 %). There was a 35.48 % incidence of local breast cancer recurrence in eight observational studies on oncological risk. Seven of the eight included only women with advanced cancer. One of these studies reported the incidence and relapse time predominantly according to the primary tumor size.

Conclusions

Although the oncological risk remains unclear, there was a high volume of complications that affected the digestive system. These findings suggest that omentum has well established applicability, but only for total breast reconstruction of huge defects, where muscular/myocutaneous or perforator flaps may be unsuitable.

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References

  1. Kiricuta I. Lemploi du grand épiploon dans la chirurgie du sein cancéreux. Presse Med. 1963;71:1.

    Google Scholar 

  2. Cort DF, Collis JL. Omental transposition in the treatment of radionecrosis. Br J Surg. 1973;60(7):580–2.

    Article  CAS  PubMed  Google Scholar 

  3. Gue S. Omental transfer for the treatment of radionecrosis of the chest wall. Aust N Z J Surg. 1975;45(4):390–4.

    Article  CAS  PubMed  Google Scholar 

  4. Góes JCS. Aesthetic improvements in Poland’s syndrome treatment with omental flap. Aesthet Plast Surg. 2010;34(5):640–1.

    Article  Google Scholar 

  5. Zaha H, Onomura M, Nomura H, Umekawa K, Oki M, Asato H. Free omental flap for partial breast reconstruction after breast-conserving surgery. Plast Reconstr Surg. 2012;129(3):583–7.

    Article  CAS  PubMed  Google Scholar 

  6. Chalmers P, Newing R. Influence of omentum transposition on experimental tumors. J Surg Oncol. 1986;32(3):135–7.

    Article  CAS  PubMed  Google Scholar 

  7. ASPRS 1987. Report on autologous fat transplantation: ASPRS Ad-Hoc Committee on New Procedures. Plast Surg Nurs.7:140.

    Article  Google Scholar 

  8. Figueiredo JCA, Naufal RR, Claro Jr F, Arias V, Pereira PRB, Cirino LMI. Prefabricated flap composed by skin and terminal gastromental vessels: experimental study in rabbits. J Plast Reconstr Aesthet Surg. 2010;63(6):e525–8.

    Article  PubMed  Google Scholar 

  9. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006–12.

    Article  PubMed  Google Scholar 

  10. Claro Jr F, Sarian LOZ, Pinto-Neto AM. Current applicability of omentum for breast surgery. In: PROSPERO. York, UK: University of York Centre of Reviews and Dissemination; 2013. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42013005493.

  11. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. New york:Wiley Online Library; 2008.

    Book  Google Scholar 

  12. Atkins D, Eccles M, Flottorp S, et al. Systems for grading the quality of evidence and the strength of recommendations. I. Critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res. 2004;4(1):38.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  14. Van Garderen J, Wiggers T, Van Geel A. Complications of the pedicled omentoplasty. Neth J Surg. 1991;43(5):171–4.

    PubMed  Google Scholar 

  15. Góes JCS, Macedo ALV. Immediate reconstruction after mastectomy using a periareolar approach with an omental flap and mixed mesh support. Perspect Plast Surg. 1996;10(1):69–81.

    Google Scholar 

  16. Van Geel AN, Contant CM, Wiggers T. Full thickness resection of radiation‐induced ulcers of the chest wall: reconstruction with absorbable implants, pedicled omentoplasty, and split skin graft. Eur J Surg. 1998;164(4):305–7.

    Article  PubMed  Google Scholar 

  17. Góes J, Macedo A. Immediate reconstruction after skin-sparing mastectomy using omental flap and synthetic mesh. In: Spear S, ed. Surgery of the Breast: Principles and Art. Philadelphia: Lippincott; 2006:786–93.

    Google Scholar 

  18. Góes JCS, Macedo ALV. Omentum reconstruction of the breast. In: Neligan PC, ed. Plastic Surgery, vol 5. New York: Elsevier Science; 2013:472–81.

    Google Scholar 

  19. Pairolero PC, Arnold PG. Thoracic wall defects: surgical management of 205 consecutive patients. Mayo Clin Proc. 1986;61(7):557–63.

    Article  CAS  PubMed  Google Scholar 

  20. Bocchi A, Merelli S, Papadia F, Caleffi E, Papadia F. Radiodermatitis and radionecrosis: clinical problems and present therapeutic principles. Chirurgia (Bucur). 2000;13(4):201–6.

    Google Scholar 

  21. Ruihua L, Xiaowu C, Jianxiong L. The use of omentum in clinical surgery. Lingnan Mod Clin Surg. 2002;4:10.

    Google Scholar 

  22. Calderoli H, Keiling R. Covering of substantial loss of substance in breast cancer with local complications: apropos of 57 cases. Acta Chir Belg. 1985;85(1):1–8.

    CAS  PubMed  Google Scholar 

  23. Calderoli H, Rohr S, Bachellier C, et al Locoregional recurrence of breast cancer: long-term course of 49 cases treated by excision and omentoplasty. Chirurgie. 1989;115(10):767–71.

    CAS  PubMed  Google Scholar 

  24. Peiper M, Langwieler T, Thomssen C, Busch C, Izbicki J, Knoefel W. Omentoplasty and secondary split skin grafting for reconstruction of large chest wall defects after resection of locally advanced breast cancer. Chir Prax. 2002;58(1):57–62.

    Google Scholar 

  25. Zaha H, Inamine S, Naito T, Nomura H. Laparoscopically harvested omental flap for immediate breast reconstruction. Am J Surg. 2006;192(4):556–8.

    Article  PubMed  Google Scholar 

  26. Costa SS, Blotta RM, Mariano MB, Meurer L, Edelweiss MIA. Laparoscopic treatment of Poland’s syndrome using the omental flap technique. Clinic (Sao Paulo). 2010;65(4):401–6.

    Article  Google Scholar 

  27. Zaha H, Sunagawa H, Kawakami K, Touyama T, Yonaha T, Ohshiro N. Partial breast reconstruction for an inferomedial breast carcinoma using an omental flap. World J Surg. 2010;34(8):1782–7.

    Article  PubMed  Google Scholar 

  28. Villa MT, Chang DW. Muscle and omental flaps for chest wall reconstruction. Thorac Surg Clin. 2010;20(4):543-50.

    Article  PubMed  Google Scholar 

  29. Al-Kattan KM, Breach NM, Kaplan DK, Goldstraw P. Soft-tissue reconstruction in thoracic surgery. Ann Thorac Surg. 1995;60(5):1372–5.

    Article  CAS  PubMed  Google Scholar 

  30. Tjalma W, Van Schil P, Verbist AM, Buytaert P, van Dam P. Chest wall resection for local recurrence of breast cancer. Eur J Obstet Gynecol Reprod Biol 1999;84(1):89–92.

    Article  CAS  PubMed  Google Scholar 

  31. McKenna Jr RJ, McMurtrey MJ, Larson DL, Mountain CF. A perspective on chest wall resection in patients with breast cancer. Ann Thorac Surg. 1984;38(5):482–7.

    Article  PubMed  Google Scholar 

  32. Arnold PG, Pairolero PC. Chest wall reconstruction: experience with 100 consecutive patients. Ann Surg. 1984;199(6):725.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Calderoli H, Schoenahl C, Keiling R. Repair of substantial tissue losses in cases of cancer of the breast with local complications. Minerva Chir. 1985;40(15-16):1049–56.

    CAS  PubMed  Google Scholar 

  34. Hoch J, Durst J. Transposition of the greater omentum for reconstruction of the chest wall after palliative excision of carcinoma of the breast. Med Welt. 1985;36(48):1535–9.

    Google Scholar 

  35. Kuwabara Y, Niwa H, Hoshino T, et al. A case of full thickness chest wall resection reconstructed with Marlex polyethylene mesh, transposed omentum and a split-skin-graft in local recurrence breast cancer. Kyobu Geka. 1986;39(9):743.

    CAS  PubMed  Google Scholar 

  36. Nakao K, Miyata M, Ito T, et al. Omental transposition and skin graft in patients for advanced or recurrent breast cancer. Jpn J Surg. 1986;16(2):112–7.

    Article  CAS  PubMed  Google Scholar 

  37. Hollinger A, Metzger U, Largiadèr F. Surgical treatment of limited local recurrence in breast carcinoma. Schweiz Rundsch Med Prax. 1986;75(17):.491-4.

    CAS  PubMed  Google Scholar 

  38. Abbott W, White H. Omental transposition for recurrent breast carcinoma following limited surgical excision and radiation therapy. Eur J Surg Oncol. 1986;12(1):59–66.

    CAS  PubMed  Google Scholar 

  39. Rostom A, El-Sayed M. Fat necrosis of the breast: an unusual complication of lumpectomy and radiotherapy in breast cancer. Clin Radiol. 1987;38(1):31.

    Article  CAS  PubMed  Google Scholar 

  40. Petit JY, Zeckri A. Partial reconstruction of the breast after necrosis following conservative treatment. Eur J Plast Surg 1987;10(3):125–7.

    Article  Google Scholar 

  41. Zoetmulder F, Van Dongen J. Chest wall resection in the treatment of local recurrence of breast cancer. Eur J Surg Oncol. 1988;14(2):127–32.

    CAS  PubMed  Google Scholar 

  42. Pittam M, Lamont P, Meirion Thomas J. Omental viability and incisional herniation after omental transposition for the repair of chest wall defects. Br J Surg. 1988;75(1):72.

    Article  Google Scholar 

  43. Williams R, Fryatt I, Abbott W, White H. Omental transposition in the treatment of locally advanced and recurrent breast cancer. Br J Surg. 1989;76(6):559–63.

    Article  CAS  PubMed  Google Scholar 

  44. Milanov N, Bardyshev M, Shilov B, Trofimov E. Autotransplantation of the greater omentum in patients with radiation injuries of the integumentary tissues. Khirurgiia (Sofiia). 1989(5):84–7.

  45. Nagadowska M, Luboiński G. Use of the greater omentum in the treatment of post-radiation necrosis of the whole thickness of the chest wall. Pol Tyg Lek. 1988;44(2-3):53–4.

    Google Scholar 

  46. Erol OO, Spira M. Reconstructing the breast mound employing a secondary island omental skin flap. Plast Reconstr Surg. 1990;86(3):510–8.

    Article  CAS  PubMed  Google Scholar 

  47. Lee S, Cheah D, Krishnan M. Omental transposition flap and split skin graft for locally advanced breast carcinoma. Singap Med J. 1990;31(3):217–20.

    CAS  PubMed  Google Scholar 

  48. Lopez J, Bouchet Y, Dupre A. The Kiricuta procedure in reconstructive surgical treatment of the breast. Surg Gynecol Obstet. 1990;170(3):209–11.

    CAS  PubMed  Google Scholar 

  49. Abbes M, Mateu J, Giordano P, Bourgeon Y. Chest wall reconstruction after full thickness resection: an experience with 22 patients. Eur J Surg Oncol. 1991;17(4):342–9.

    CAS  PubMed  Google Scholar 

  50. Viiachki I, Viiachki D, Penkov N, Kirov R, Ivanov A. Omentoplasty in recurrent carcinoma of the chest wall following mammectomy. Khirurgiia (Sofiia). 1991;44(6)73–6.

  51. Calderoli H. Breast cancer: temporal evolution of loco-regional recurrence treated by omentoplasty: a study of 49 cases. Helv Chir Acta. 1991;58(1-2):89.

    CAS  PubMed  Google Scholar 

  52. Papadia F, Bocchi A, Caleffi E, Toschi S. Surgical treatment of radiation injures in post-mastectomy patients. Riv Ital Chir Plast. 1992;24(1):39–45.

  53. Samuels L, Granick MS, Ramasastry S, Solomon MP, Hurwitz D. Reconstruction of radiation-induced chest wall lesions. Ann Plast Surg. 1993;31(5):399–405.

    Article  CAS  PubMed  Google Scholar 

  54. Corral CJ, Prystowsky JB, Weidrich TA, Harris GD. Laparoscopic-assisted bipedicle omental flap mobilization for reconstruction of a chest wall defect. J Laparoendosc Surg 1994;4(5):343–6.

    Article  CAS  PubMed  Google Scholar 

  55. Zhang YW. Treatment of 5 cases of thoracic wall radiation ulcer by pedunculated greater omentum and skin graft. Chin J Clin Oncol. 1993;20(6):417–8.

    Google Scholar 

  56. Ribuffo D, Codner M, Nahai F. Breast reconstruction with microsurgical flaps. Riv Ital Chir Plasta. 1994;26:283–90.

    Google Scholar 

  57. Rouanet P, Fabre JM, Tica V, Anaf V, Jozwick M, Pujol H. Chest wall reconstruction for radionecrosis after breast carcinoma therapy. Ann Plast Surg. 1995;34(5):465–70.

    Article  CAS  PubMed  Google Scholar 

  58. Contant CM, van Geel AN, van der Holt B, Wiggers T. The pedicled omentoplasty and split skin graft (POSSG) for reconstruction of large chest wall defects: validity study of 34 patients. Eur J Surg Oncol. 1996;22(5):532–7.

    Article  CAS  PubMed  Google Scholar 

  59. Bufo AJ, Shah R, Lobe TE, Smoot CE. Laparoscopic transposition of the omentum for reconstructive surgery. Pediatr Endosurg Innov Tech. 1997;1(4):217–21.

    Article  Google Scholar 

  60. Cheung KL, Willsher PC, Robertson JF, Bailie FB, Daly JC, Blamey RW. Omental transposition flap for gross locally recurrent breast cancer. Aust N Z J Surg. 1997;67(4):185–6.

    Article  CAS  PubMed  Google Scholar 

  61. Nemsadze G, Gogoberidze Z, Katashvili D, Dzagnidze I, Sikharulidze G. Breast cancer: a new technique of reconstruction. Eur J Cancer. 1998;34:S27.

    Article  Google Scholar 

  62. Fui AC, Hong GS, Ng EH, Soo KC. Primary reconstruction after extensive chest wall resection. Aust N Z J Surg 1998;68(9):655–9.

    Article  CAS  PubMed  Google Scholar 

  63. Hultman CS, Culbertson JH, Jones GE, et al. Thoracic reconstruction with the omentum: indications, complications, and results. Ann Plast Surg. 2001;46(3):242–9.

    Article  CAS  PubMed  Google Scholar 

  64. Cothier-Savey I, Tamtawi B, Dohnt F, Raulo Y, Baruch J. Immediate breast reconstruction using a laparoscopically harvested omental flap. Plast Reconstr Surg. 2001;107(5):1156–63; discussion 1164–5.

  65. Henderson MA, Burt JD, Jenner D, Crookes P, Bennett RC. Radical surgery with omental flap for uncontrolled locally recurrent breast cancer. ANZ J Surg. 2001;71(11):675–9.

    Article  CAS  PubMed  Google Scholar 

  66. Peiper M, Langwieler T, Thomssen C, Busch C, Izbicki J, Knoefel W. Omentoplasty and secondary split skin grafting for reconstruction of large chest wall defects after resection of locally advanced breast cancer. Gynakol Praxis. 2002;26(2):287–92.

    Google Scholar 

  67. Ida K. Pedicle omental graft created by laparoscopic surgery for filling a radiation-induced ulcer in a woman with breast cancer. Nippon Rinsho Geka Gakkai Zasshi 2002;63(6):1366-9.

  68. Jimenez AG, St Germain P, Sirois M, Hatheway M, Lethbridge R. Free omental flap for skin-sparing breast reconstruction harvested laparoscopically. Plast Reconstr Surg. 2002;110(2):545–51.

    Article  PubMed  Google Scholar 

  69. Sato M, Tanaka F, Wada H. Treatment of necrotic infection on the anterior chest wall secondary to mastectomy and postoperative radiotherapy by the application of omentum and mesh skin grafting: report of a case. Surg Today. 2002;32(3):261–3.

    Article  PubMed  Google Scholar 

  70. Kamei Y, Torii S, Toriyama K. Breast reconstruction using omentum harvested by endoscopic surgery: a case report. Jpn J Plast Reconstr Surg. 2003;46(5):509–14.

    Google Scholar 

  71. Hogewind B, Boutkan H, de Jager-Nowak H, Merkus J. Angiosarcoma following breast-conserving therapy. Ned Tijdschr Geneeskd. 2004;148(20):995–7.

    CAS  PubMed  Google Scholar 

  72. Kulakowski A, Sluszniak J, Zielinski A, Gozdz S. The greater omentum in the surgical treatment of radionecrosis considering breast cancer patients. Pol Przegl Chir. 2005;77(4):323–34.

    Google Scholar 

  73. Novoa N, Benito P, Jimenez MF, de Juan A, Luis Aranda J, Varela G. Reconstruction of chest wall defects after resection of large neoplasms: ten-year experience. Interact Cardiovasc Thorac Surg. 2005;4(3):250–5.

    Article  PubMed  Google Scholar 

  74. Kolodziejski LS, Wysocki WM, Komorowski AL. Full-thickness chest wall resection for recurrence of breast malignancy. Breast J. 2005;11(4):273–7.

    Article  PubMed  Google Scholar 

  75. Ferron G, Garrido I, Martel P, et al. Combined laparoscopically harvested omental flap with meshed skin grafts and vacuum-assisted closure for reconstruction of complex chest wall defects. Ann Plast Surg. 2007;58(2):150–5.

    Article  CAS  PubMed  Google Scholar 

  76. Han MY, Qiu XD, Lian H, Liu H, Jin RT. Clinical application of breast reconstruction after mastectomy. Inner Mongolia Med J. 2008;9:15.

    Google Scholar 

  77. Aukema TS, Russell NS, Wesseling J, Rutgers EJ. Extensive soft tissue resection with autologous tissue closure for locally recurrent breast cancer: lasting local control and acceptable morbidity. Eur J Surg Oncol. 2009;35(5):469–74.

    Article  CAS  PubMed  Google Scholar 

  78. Lans TE, van der Pol C, Wouters MW, Schmitz PI, van Geel AN. Complications in wound healing after chest wall resection in cancer patients: a multivariate analysis of 220 patients. J Thorac Oncol. 2009;4(5):639–43.

    Article  PubMed  Google Scholar 

  79. Aquilina D, Darmanin FX, Briffa J, Gatt D. Chest wall reconstruction using an omental flap and Integra. J Plast Reconstr Aesthet Surg. 2009;62(7):e200–2.

    Article  CAS  PubMed  Google Scholar 

  80. Costa SS, Blotta R, Mariano M, Meurer L, Edelweiss M. Aesthetic improvements in Poland’s syndrome treatment with omental flap. Aesthet Plast Surg. 2010;34(5):634–9.

    Article  Google Scholar 

  81. Zaha H, Inamine S. Laparoscopically harvested omental flap: results for 96 patients. Surg Endosc. 2010;24(1):103–7.

    Article  PubMed  Google Scholar 

  82. Bosc R, Lepage C, Hamou C, et al. Management of chest wall reconstruction after resection for cancer: a retrospective study of 22 consecutive patients. Ann Plast Surg. 2011;67(3):263–8.

    Article  CAS  PubMed  Google Scholar 

  83. Song X, Guan D, Lin H, et al. Immediate breast reconstruction using laparoscopically harvested omental flap after breast-conserving surgery. Zhonghua Zheng Xing Wai Ke Za Zhi 2011;27(6):401–5.

    PubMed  Google Scholar 

  84. Costa SS, Blotta RM, Meurer L, Edelweiss MIA. Adipocyte morphometric evaluation and angiogenesis in the omentum transposed to the breast: a preliminary study. Clinics (Sao Paolo). 2011;66(2):307–12.

    Article  Google Scholar 

  85. Khater A. Evaluation of pedicled omental flap delivered through a minilaparotomy for immediate breast reconstruction in obese patients. Aesthet Plast Surg. 2013;37(6):1140–5.

    Article  Google Scholar 

  86. Romanini MV, Vidal C, Godoy J, Morovic CG. Laparoscopically harvested omental flap for breast reconstruction in Poland syndrome. J Plast Reconstr Aesthet Surg. 2013;66(11):e303–9.

    Article  CAS  PubMed  Google Scholar 

  87. Hartmann CE, Ko LW, Ion L, Jemec B. A difficult case: omental transposition flap reconstruction of a large radionecrotic axillary ulcer in a patient with extensive previous abdominal surgery. J Plast Reconstr Aesthet Surg. 2013;66(3):e66–8.

    Article  PubMed  Google Scholar 

  88. Dupont C, Menard Y. Transposition of the greater omentum for reconstruction of the chest wall. Plast Reconstr Surg. 1972;49(3):263–7.

    Article  CAS  PubMed  Google Scholar 

  89. Santi P, Berrino P, Galli A. Poland’s syndrome: correction of thoracic anomaly through minimal incisions. Plast Reconstr Surg. 1985;76(4):639–41.

    Article  CAS  PubMed  Google Scholar 

  90. Trabulsy PP, Anthony JP, Mathes SJ. Changing trends in postmastectomy breast reconstruction: a 13-year experience. Plast Reconstr Surg. 1994;93(7):1418–27.

    Article  CAS  PubMed  Google Scholar 

  91. Mehrara BJ, Santoro TD, Arcilla E, Watson JP, Shaw WW, Da Lio AL. Complications after microvascular breast reconstruction: experience with 1195 flaps. Plast Reconstr Surg. 2006;118(5):1100–9; discussion 1110–1.

  92. Kronowitz SJ, Robb GL. Radiation therapy and breast reconstruction: a critical review of the literature. Plast Reconstr Surg. 2009;124(2):395–408.

    Article  CAS  PubMed  Google Scholar 

  93. Claro Jr F, da Costa DV, Pinheiro AdS, Pinto-Neto AM. Complications in total breast reconstruction in patients treated for breast cancer: long-term comparative analysis of the influence of the technique, operative time, timing of reconstruction, and adjuvant treatment. Rev Bras Cir Plast. 2013;28(1):85–91.

  94. Claro Jr F, Figueiredo JCA, Zampar AG, Pinto-Neto AM. Applicability and safety of autologous fat for reconstruction of the breast. Br J Surg 2012;99(6):768–80.

    Article  PubMed  Google Scholar 

  95. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res. 1995;3(S2):187s–94s.

    Article  PubMed  Google Scholar 

  96. Manabe Y, Toda S, Miyazaki K, Sugihara H. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions. J Pathol. 2003;201(2):221–8.

    Article  PubMed  Google Scholar 

  97. Iyengar P, Combs TP, Shah SJ, et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 2003;22(41):6408–23.

    Article  CAS  PubMed  Google Scholar 

  98. Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer. 2007;14(2):189–206.

    Article  CAS  PubMed  Google Scholar 

  99. Vona‐Davis L, Howard‐McNatt M, Rose D. Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev. 2007;8(5):395–408.

    Article  CAS  PubMed  Google Scholar 

  100. Hou WK, Xu YX, Yu T, et al. Adipocytokines and breast cancer risk. Chin Med J (Engl). 2007;120(18):1592.

    CAS  PubMed  Google Scholar 

  101. Jurgens WJ, Oedayrajsingh-Varma MJ, Helder MN, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell Tissue Res. 2008;332(3):415–26.

    Article  PubMed Central  PubMed  Google Scholar 

  102. Yu JM, Jun ES, Bae YC, Jung JS. Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo. Stem Cells Dev. 2008;17(3):463–74.

    Article  CAS  PubMed  Google Scholar 

  103. Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Petit JY. Autologous fat transplantation in patients with breast cancer:“silencing” or “fueling” cancer recurrence? Breast. 2011;20(4):351–7.

    Article  PubMed  Google Scholar 

  104. Carter JC, Church FC. Mature breast adipocytes promote breast cancer cell motility. Exp Mol Pathol. 2012;92(3):312–7.

    Article  CAS  PubMed  Google Scholar 

  105. Slavin SA, Love SM, Goldwyn RM. Recurrent breast cancer following immediate reconstruction with myocutaneous flaps. Plast Reconstr Surg. 1994;93(6):1191–204; discussion 1205–7.

  106. Kroll SS, Schusterman MA, Tadjalli HE, Singletary SE, Ames FC. Risk of recurrence after treatment of early breast cancer with skin-sparing mastectomy. Ann Surg Oncol. 1997;4(3):193–7.

    Article  CAS  PubMed  Google Scholar 

  107. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227–32.

    Article  PubMed  Google Scholar 

  108. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–41.

    Article  PubMed  Google Scholar 

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Acknowledgment

This research was supported by the salary provided to Dr. Claro Jr. by “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES),” a Brazilian federal institution for postgraduate programs.

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The authors of this manuscript have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, School of Medical Sciences, State University of Campinas – UNICAMP, Rua Alexander Fleming, 101, Campinas, 13083-881, SP, Brazil

    Francisco Claro Jr. MD, Luís Otávio Zanatta Sarian MD, PhD & Aarão Mendes Pinto-Neto MD, PhD

  2. Santa Cruz Plastic Surgery Institute – ICPSC, São Paulo, SP, Brazil

    Francisco Claro Jr. MD

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  1. Francisco Claro Jr. MD
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  2. Luís Otávio Zanatta Sarian MD, PhD
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  3. Aarão Mendes Pinto-Neto MD, PhD
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Correspondence to Francisco Claro Jr. MD.

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Claro, F., Sarian, L.O.Z. & Pinto-Neto, A.M. Omentum for Mammary Disorders: A 30-Year Systematic Review. Ann Surg Oncol 22, 2540–2550 (2015). https://doi.org/10.1245/s10434-014-4328-8

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