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Surgery for Gastrointestinal Stromal Tumors of the Duodenum

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Duodenal gastrointestinal stromal tumors (GISTs) represent a unique dilemma with varied surgical treatment options. However, the impact of operative methods on disease recurrence has never been addressed.

Methods

We retrospectively reviewed the medical records of all patients with duodenal GISTs treated at our hospital from January 2001 to December 2008.

Results

Of the 25 patients included for analysis, 9 had pancreaticoduodenectomy (PD) and 16 had limited operation. Comparison of clinicopathological data between tumors treated by PD and by limited operation showed no significant differences in patient age, sex, symptoms, location of tumor, tumor grade, immunohistochemical staining pattern, or complications after surgery. However, patients with tumors >5 cm (P = 0.005) or not diagnosed as GISTs before surgery (P = 0.004) were significantly more frequently treated by PD. In multivariable analysis, the only significant predictor for disease recurrence was high-risk duodenal GISTs.

Conclusions

Based on the fact that type of operation was not correlated to operative risk and disease recurrence, limited operation rather than PD should be attempted for duodenal GIST without involvement of papilla of Vater to preserve more pancreas parenchyma, duodenum, and common bile duct.

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Authors and Affiliations

  1. Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC

    Yu-Wen Tien MD, Chih-Yuan Lee MD, Rey-Heng Hu MD & Po-Huang Lee MD

  2. Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC

    Chun-Chieh Huang MD

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  1. Yu-Wen Tien MD
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  2. Chih-Yuan Lee MD
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  3. Chun-Chieh Huang MD
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  4. Rey-Heng Hu MD
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  5. Po-Huang Lee MD
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Correspondence to Yu-Wen Tien MD.

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Tien, YW., Lee, CY., Huang, CC. et al. Surgery for Gastrointestinal Stromal Tumors of the Duodenum. Ann Surg Oncol 17, 109–114 (2010). https://doi.org/10.1245/s10434-009-0761-5

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  • DOI: https://doi.org/10.1245/s10434-009-0761-5

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