Stressful life events can change the clinical expression of rheumatoid arthritis (RA). Stress increases the proinflammatory load in healthy individuals and patients with RA. A new study demonstrates that short-term experimental stress transiently increases serum IL-1β and IL-2 levels in patients with RA, but how does stress affect chronic inflammation?
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References
de Brouwer, S. J. et al. Immune responses to stress in rheumatoid arthritis and psoriasis. Rheumatology (Oxford) http://dx.doi.org/10.1093/rheumatology/keu221.
Straub, R. H. & Kalden, J. R. Stress of different types increases the proinflammatory load in rheumatoid arthritis. Arthritis Res. Ther. 11, 114 (2009).
Steptoe, A., Hamer, M. & Chida, Y. The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav. Immun. 21, 901–912 (2007).
Bierhaus, A. et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc. Natl Acad. Sci. USA 100, 1920–1925 (2003).
Straub, R. H., Cutolo, M., Buttgereit, F. & Pongratz, G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J. Intern. Med. 267, 543–560 (2010).
Glaser, R. & Kiecolt–Glaser, J. K. Stress-induced immune dysfunction: implications for health. Nat. Rev. Immunol. 5, 243–251 (2005).
Okada Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376–381 (2014).
Vereecke, L., Beyaert, R. & van Loo, G. The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol. 30, 383–391 (2009).
Straub, R. H. et al. Anti-inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro. FASEB J. 16, 993–1000 (2002).
Eraly, S. A. et al. Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry 71, 423–431 (2014).
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Straub, R. Stress in RA: a trigger of proinflammatory pathways?. Nat Rev Rheumatol 10, 516–518 (2014). https://doi.org/10.1038/nrrheum.2014.110
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DOI: https://doi.org/10.1038/nrrheum.2014.110
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