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Enzalutamide: A Review in Castration-Resistant Prostate Cancer

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Abstract

Oral enzalutamide (Xtandi®), a second generation androgen receptor inhibitor, is indicated for the treatment of castration-resistant prostate cancer (CRPC) in numerous countries worldwide, with specific indications in this patient population varying between individual countries. Based on extensive experience in the clinical trial and/or real-world settings, oral enzalutamide 160 mg once daily is an effective and generally well tolerated treatment in a broad spectrum of patients with CRPC, including in nonmetastatic and metastatic disease and in chemotherapy-naive and -experienced metastatic CRPC. Enzalutamide is an emerging option for the treatment of men with nonmetastatic CRPC who are at high-risk for developing metastatic disease, and remains an important first-line option in chemotherapy-naive or -experienced patients with metastatic CRPC.

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Acknowledgements

During the peer review process, the manufacturer of enzalutamide was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.

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    Lesley J. Scott

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Lesley Scott is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.

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The manuscript was reviewed by: M. Chovanec, 2nd Department of Oncology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; U. Emmenegger, Sunnybrook Odette Cancer Centre, Division of Medical Oncology, University of Toronto, Toronto, ON, Canada.

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Scott, L.J. Enzalutamide: A Review in Castration-Resistant Prostate Cancer. Drugs 78, 1913–1924 (2018). https://doi.org/10.1007/s40265-018-1029-9

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