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The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment

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Tumor Biology

Abstract

Despite recent progresses in tumor therapy and increased knowledge in tumor biology, tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a subset of cancer cells with a stem cell-like ability, which may drive tumor growth and recurrence and are resistant to many current anticancer treatments. Solid tumors are regarded as “organs” which are comprised of cancer cells and the tumor stroma. The tumor microenvironment makes up the stroma of the tumor, which occupies the majority of the tumor mass, including the extracellular matrix (ECM), mesenchymal stem cells (MSCs), endothelial cells, immune cells, and, what is more, networks of cytokines and growth factors. The microenvironment or niche surrounding CSCs largely governs their cellular fate. Recent work has revealed that the microenvironment supports CSC self-renewal and simultaneously serves as a physical barrier to drug delivery. The tumor microenvironment plays pivotal roles in each stage of tumor development. Knowledge about the interactions of CSCs with their microenvironment would seem to be of most importance for developing new treatment strategies.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (no. 91019005, no. 81272672) and Zhejiang Provincial Natural Science Foundation of China (no. Y2110034).

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Authors and Affiliations

  1. Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

    Jun Ye

  2. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009, China

    Jun Ye, Dang Wu, Pin Wu, Zhigang Chen & Jian Huang

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  2. Dang Wu
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Correspondence to Zhigang Chen or Jian Huang.

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Jun Ye, Dang Wu, and Pin Wu contributed equally to this work.

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Ye, J., Wu, D., Wu, P. et al. The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment. Tumor Biol. 35, 3945–3951 (2014). https://doi.org/10.1007/s13277-013-1561-x

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