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Aberrant Immunophenotypic Expression of CD5 in a Case of B Acute Lymphoblastic Leukemia: A Case Report

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Aberrant expression of CD5 has rarely been reported in B cell lineage acute lymphoblastic leukemia (B-ALL). We report the rare immunophenotypic expression of CD5 in a 20-year-old male who was diagnosed to have B-ALL on bone marrow examination. Cytogenetic analysis revealed a mosaic supernumerary marker chromosome. The patient died due to acute pancreatitis after admission. CD5 positive B-ALL may represent a distinct clinicopathologic subcategory of B-ALL with an aggressive clinical course.

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References

  1. Jevremovic D, Dronca RS, Morice WG, McPhail ED, Kurtin PJ, Zent CS et al (2010) CD5+ B-cell lymphoproliferative disorders: beyond chronic lymphocytic leukemia and mantle cell lymphoma. Leuk Res 34(9):1235–1238

    Article  PubMed  CAS  Google Scholar 

  2. Peterson MR, Noskoviak KJ, Newbury R (2007) CD5-positive B-cell acute lymphoblastic leukemia. Pediatr Dev Pathol 10(1):41–45

    Article  PubMed  Google Scholar 

  3. Subirá D, Roman A, Jiménez-Garófano C, Prieto E, Martínez-Delgado B, Aceituno E et al (1998) Brief report. CD19/CD5 acute lymphoblastic leukemia. Med Pediatr Oncol 31(6):551–552

    Article  PubMed  Google Scholar 

  4. Ahmed D, Ahmed TA, Ahmed S, Tipu HN, Wiqar MA (2008) CD5-positive acute lymphoblastic leukemia. J Coll Physicians Surg Pak 18(5):310–311

    PubMed  Google Scholar 

  5. Seegmiller AC, Kroft SH, Karandikar NJ, McKenna RW (2009) Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia. Am J Clin Pathol 132(6):940–949

    Article  PubMed  CAS  Google Scholar 

  6. Hussein S, Gill KZ, Sireci AN, Colovai AI, Small T, Emmons FN et al (2011) Aberrant T-cell antigen expression in B lymphoblastic leukaemia. Br J Haematol 155(4):449–456

    Article  PubMed  CAS  Google Scholar 

  7. Gary-Gouy H, Harriague J, Bismuth G, Platzer C, Schmitt C, Dalloul AH (2002) Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production. Blood 100(13):4537–4543

    Article  PubMed  CAS  Google Scholar 

  8. Reddy KS, Aradhya S, Meck J, Tiller G, Abboy S, Bass H (2013) A systematic analysis of small supernumerary marker chromosomes using array CGH exposes unexpected complexity. Genet Med 15(1):3–13

    Article  PubMed  CAS  Google Scholar 

  9. Ogden A, Rida PCG, Aneja R (2013) Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration. Cancer Metastasis Rev 32(1–2):269–287

    Article  PubMed  PubMed Central  Google Scholar 

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The author(s) declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Haematology, All India Institute of Medical Sciences, New Delhi, India

    Deepti Mutreja, Hara Prasad Pati, Divya Bansal, Rahul Kumar Sharma & Sonal Jain

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  1. Deepti Mutreja
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  2. Hara Prasad Pati
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  3. Divya Bansal
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  4. Rahul Kumar Sharma
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  5. Sonal Jain
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Correspondence to Deepti Mutreja.

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Mutreja, D., Pati, H.P., Bansal, D. et al. Aberrant Immunophenotypic Expression of CD5 in a Case of B Acute Lymphoblastic Leukemia: A Case Report. Indian J Hematol Blood Transfus 30 (Suppl 1), 212–214 (2014). https://doi.org/10.1007/s12288-014-0332-1

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  • DOI: https://doi.org/10.1007/s12288-014-0332-1

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