Abstract
Adenoid cystic carcinoma (ACC) is an uncommon malignant epithelial tumor occurring in head neck region, accounting for approximately 10% of all salivary gland neoplasms. Extra-salivary gland involvement of other head neck subsites by ACC may present in unusual modes creating clinical dilemma. Here we present some cases with extra-salivary gland ACC. In this series six cases with extra-salivary gland ACC were included. Three patients presented with external auditory canal and temporo-mastoid region involvement of whom two cases also had intracranial extension. In one case tongue was the site of involvement where it was confused with benign neurogenic tumour. Palatal erosion with formation of oro-nasal fistula was the the manifestation of ACC involving palate. On the other hand sinonasal bleeding mass which came out as ACC on histopathological examination did not cause any palatal erosion and was removed successfully via lateral rhiniotomy. In all these cases patients were treated with post-operative radiotherapy and were closely followed up for early detection of any distant metastasis. The experience about the various unusual manifestations of ACC and the therapeutic challenge poised by the cases is discussed here.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Maciejewski A, Szymczyk C, Wierzgoń J (2002) Outcome of surgery for adenoid cystic carcinoma of head and neck region. J Craniomaxillofac Surg 30(1):59–61
Bradley PJ (2004) Adenoid cystic carcinoma of the head and neck: a review. Curr Opin Otolaryngol Head Neck Surg 12:127–132
Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Koufogiannis D (2006) Management of adenoid cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg 64(7):1114–1120
Stell PM (1986) Adenoid cystic carcinoma. Clin Otolaryngol 11:267–291
Spies JW (1930) Adenoid cystic carcinoma. Arch Surg 21:365–404
Foote FW, Frazell EL (1953) Tumours of the major salivary glands. Cancer 6:1065–1133
Conley J, Dingman DL (1974) Adenoid cystic carcinoma in the head and neck (cylindroma). Arch Otolaryngol 100:81–90
Matsuba HM, Spector GJ, Thawley SE et al (1986) Adenoid cystic salivary gland carcinoma: a histologic review of treatment failure patterns. Cancer 57:519–524
Westra WH (1999) The surgical pathology of salivary gland neoplasms. Otolaryngol Clin North Am 39:919–943
Szanto PA, Luna MA, Tortoledo ME et al (1984) Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 54:1062–1069
Matsuba HM, Simpson JR, Mauney M et al (1986) Adenoid cystic salivary gland carcinoma: a clinico-pathologic correlation. Head Neck Surg 8:200–204
Eveson JW, Cawson RA (1985) Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 14(6):500–509
Perzin KH, Gullane P, Conley J (1982) Adenoid cystic carcinoma involving the external auditory canal. A clinicopathologic study of 16 cases. Cancer 50(12):2873–2883
Abe T, Kondo A, Suga M, Sunami N, Yamamoto Y (2004) Adenoid cystic carcinoma with striking intracranial extension: a case report (Article in Japanese). No Shinkei Geka 32(8):851–856
Luna-Ortiz K, Carmona-Luna T, Cano-Valdez AM, Mosqueda-Taylor A, Herrera-Gómez A, Villavicencio-Valencia V (2009) Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis. Head Neck Oncol 1:15
Khafif A, Anavi Y, Aviv J, Fienmesser R, Calderon S, Marshak G (2005) Adenoid cystic carcinoma of the salivary glands: a 20-year review with long term follow-up. Ear Nose Throat J 84:662–667
Spiro RH, Huvos AG, Strong EW (1974) Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. Am J Surg 128:512–520
Auclair PL, Ellis GL, Gnepp DR, Wenig BM, Janney CG (2008) AFIP (Armed Force Institute of Pathology): Salivary gland neoplasms. General considerations Chapter 9:135-64
Soares EC, Carreiro Filho FP, Costa FW, Vieira AC, Alves AP (2008) Adenoid cystic carcinoma of the tongue: case report and literature review. Med Oral Patol Oral Cir Bucal 13(8):E475–E478
Namazie A, Alavi S, Abemayor E, Calcaterra TC, Blackwell KE (2001) Adenoid cystic carcinoma of the base of the tongue. Ann Otol Rhinol Laryngol 110(3):248–253
Carrasco Ortiz D, Aldape Barrios B (2006) Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal 11:E417–E420
Spiro RH, Huvos AG, Strong EW (1974) Adenoid cystic carcinoma of salivary origin: A clinicopathologic study of 242 cases. Am J Surg 128(4):512–520
McMonagle BA, Gleeson M (2008) Nasal cavity and paranasal sinus malignancy. In: Gleeson M, Browning GG, Burton MJ, Clarke R, Hibbert J, Jones NS et al. (eds). Scott-Brown’s Otorhinolaryngology, Head and Neck surgery, 7th edn, vol 2. Hodder Arnold, London, pp 2415–35
Moles MA, Avila IR, Archilla AR (1999) Dedifferentiation occurring in adenoid cystic carcinoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88(2):177–180
Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Martins AS, Altemani AM et al (2006) Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J 124(1):26–30
Carrasco Ortiz D, Aldape Barrios B (2006) Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal 11(5):E417–E420
Maciel Santos MES, Ibrahim D, Neto JC, Da Silva JC, Da Silva UH, Sobral APV (2005) Carcinoma adenóide cístico: relato de caso. Rev Cir Traumatol Buco-Maxilo-Fac 5:49–54
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Biswas, K.D., Saha, J., Sen, I. et al. Unusual Presentations of Adenoid Cystic Carcinoma in Extra-Salivary Gland Subsites in Head and Neck Region: A Case Series. Indian J Otolaryngol Head Neck Surg 66 (Suppl 1), 286–290 (2014). https://doi.org/10.1007/s12070-012-0490-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-012-0490-0