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Intravenous Immunoglobulin in Lupus Panniculitis

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Abstract

Systemic lupus erythematosus (SLE) is a disease of unknown cause that may involve one or many organ or systems. Skin involvement is a major feature in this disease, and a wide variety of skin conditions may be present. Lupus erythematosus panniculitis (LEP) constitutes a rare form of cutaneous lupus characterized by recurrent nodular or plaque lesions that can vary from a benign and mild course to a more disfiguring disease. Initial therapy includes corticosteroids, antimalarials, and azathioprine and, in refractory cases, two antimalarials in association, mycophenolate mofetil, or other immunomodulators. Intravenous immuglobulin (IVIG) is used in many autoimmune disorders, like in SLE, although clinical trials have not yet taken place. In this report, we review skin manifestations of SLE and their treatment, IVIG, and finally a case of LEP successfully treated with IVIG when other therapy modalities failed.

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  1. Departement of Medicine 1, Hospital Santa Maria, Lisbon, Portugal

    João Espírito Santo, M. F. Gomes, M. J. Gomes, L. Peixoto, S. C. Pereira, A. Acabado & G. Vinhas de Sousa

  2. Departement of Dermatology, Hospital Santa Maria, Lisbon, Portugal

    J. Freitas

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  1. João Espírito Santo
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  2. M. F. Gomes
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Correspondence to João Espírito Santo.

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Espírito Santo, J., Gomes, M.F., Gomes, M.J. et al. Intravenous Immunoglobulin in Lupus Panniculitis. Clinic Rev Allerg Immunol 38, 307–318 (2010). https://doi.org/10.1007/s12016-009-8162-x

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