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Seeing Stem Cells at Work In Vivo

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Abstract

Stem cell based-therapies are novel therapeutic strategies that hold key for developing new treatments for diseases conditions with very few or no cures. Although there has been an increase in the number of clinical trials involving stem cell-based therapies in the last few years, the long-term risks and benefits of these therapies are still unknown. Detailed in vivo studies are needed to monitor the fate of transplanted cells, including their distribution, differentiation, and longevity over time. Advancements in non-invasive cellular imaging techniques to track engrafted cells in real-time present a powerful tool for determining the efficacy of stem cell-based therapies. In this review, we describe the latest approaches to stem cell labeling and tracking using different imaging modalities.

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  1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205-1832, USA

    Amit K. Srivastava & Jeff W. M. Bulte

  2. Cellular Imaging Section, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205-1832, USA

    Amit K. Srivastava & Jeff W. M. Bulte

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Srivastava, A.K., Bulte, J.W.M. Seeing Stem Cells at Work In Vivo. Stem Cell Rev and Rep 10, 127–144 (2014). https://doi.org/10.1007/s12015-013-9468-x

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