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Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review

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Abstract

The aim of this study was to systematically evaluate the relation between zinc and the thyroid hormones in humans. The search for articles was conducted using the Pubmed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and ScienceDirect databases on October 21 and 22, 2019, by two authors independently. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed in the conduct of this review. The Cochrane Collaboration tool was used to assess the risk of bias of the trials included in this review. After the screening of the articles, eight studies that assessed the effects of zinc supplementation on thyroid hormone concentrations and ten studies that assessed the relationship between blood zinc concentrations and thyroid hormones were included in this systematic review. Although cross-sectional and case-control studies have shown a relationship between zinc deficiency and thyroid, the data from this systematic review provides inconclusive evidence with respect to the effects of zinc supplementation on thyroid hormone concentrations due to the divergence of the research found by the authors that only reports findings in patients suffering from some kind of disease, which cannot be generalized to the average human population.

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Authors and Affiliations

  1. Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Teresina, Piauí, Brazil

    Jéssica Batista Beserra, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Kyria Jayanne Clímaco Cruz, Ana Raquel Soares de Oliveira & Dilina do Nascimento Marreiro

  2. Department of Nutrition, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Gilberto Simeone Henriques

  3. Departamento de Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Bairro Ininga, Teresina, Piauí, 64049550, Brazil

    Dilina do Nascimento Marreiro

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  1. Jéssica Batista Beserra
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Correspondence to Dilina do Nascimento Marreiro.

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The original version of this article unfortunately contained a mistake in Table 3. Table 3 is now updated

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Beserra, J.B., Morais, J.B.S., Severo, J.S. et al. Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review. Biol Trace Elem Res 199, 4092–4100 (2021). https://doi.org/10.1007/s12011-020-02562-5

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