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First- and Second-Generation Temporary Implantable Nitinol Devices As Minimally Invasive Treatments for BPH-Related LUTS: Systematic Review of the Literature

  • BENIGN PROSTATIC HYPERPLASIA (K MCVARY, SECTION EDITOR)
  • Published:
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Abstract

Introduction

In the last decade, there has been a growing interest in minimally invasive treatment for benign prostatic hyperplasia (BPH) associated with lower urinary tract symptoms (LUTS). In this field, one of the options currently available is the temporary implantable nitinol device (iTIND) (Medi-Tate®; Medi-Tate Ltd., Or Akiva, Israel).

Purpose of the Work

To review the recent data available in the literature regarding the role of the first-generation (TIND) and second-generation (iTIND) devices for the management of BPH with LUTS, especially focusing on follow-up of functional outcomes.

Evidence Acquisition

PubMed, Embase, and the Cochrane Central Register of Controlled Trials were screened for clinical trials on this topic.

Evidence Synthesis

Literature evidences regarding implantation of TIND and iTIND for PBH with LUTS are limited. There are only three studies available, one with a medium-term follow-up. The results of these studies suggested that both the TIND and iTIND implantations are safe, effective, and well-tolerated procedures, allowing spare ejaculation in sexually active patients.

Conclusions

Current evidences emphasize that the temporary implantable nitinol devices are promising alternatives to the standard minimally invasive surgical options for BPH-related LUTS. Further studies are needed to confirm the effectiveness over a long-term follow-up.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Authors and Affiliations

  1. Division of Urology, Department Of Oncology, School of Medicine, University of Turin, San Luigi Hospital, Regione Gonzole 10, Orbassano, 10043, Turin, Italy

    Daniele Amparore, Sabrina De Cillis, Gabriele Volpi, Enrico Checcucci, Matteo Manfredi, Ivano Morra, Michele Di Dio, Cristian Fiori & Francesco Porpiglia

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  1. Daniele Amparore
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  2. Sabrina De Cillis
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  3. Gabriele Volpi
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  4. Enrico Checcucci
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  7. Michele Di Dio
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  8. Cristian Fiori
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  9. Francesco Porpiglia
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Correspondence to Francesco Porpiglia.

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Conflict of Interest

Daniele Amparore, Sabrina De Cillis, Gabriele Volpi, Enrico Checcucci, Matteo Manfredi, Ivano Morra, Michele Di Dio, Cristian Fiori, and Francesco Porpiglia each declares no potential conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Benign Prostatic Hyperplasia

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Amparore, D., De Cillis, S., Volpi, G. et al. First- and Second-Generation Temporary Implantable Nitinol Devices As Minimally Invasive Treatments for BPH-Related LUTS: Systematic Review of the Literature. Curr Urol Rep 20, 47 (2019). https://doi.org/10.1007/s11934-019-0912-6

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  • DOI: https://doi.org/10.1007/s11934-019-0912-6

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