Skip to main content
Log in

Insomnische Störungen

Herausforderungen und offene Fragen

Insomnia disorders

Challenges and open questions

  • Schwerpunkt
  • Published:
Somnologie - Schlafforschung und Schlafmedizin Aims and scope Submit manuscript

Zusammenfassung

Aktuell gebräuchliche diagnostische Systeme wie ICD-10 oder DSM-IV werden der Komplexität und Heterogenität insomnischer Störungen nicht gerecht. Mit dem ICSD-2 und den Research Diagnostic Criteria (RDC) wurden bereits Fortschritte erreicht. Im DSM-V wird eine neue übergreifende Kategorie „insomnia disorder“ etabliert werden. Hinsichtlich Ätiologie und Pathophysiologie dominiert aktuell das sog. Hyperarousal-Modell, das allerdings auch Schwachstellen aufweist, sodass weitergehende klinische Forschung zu seiner Bestätigung aussteht. Zudem ist die Etablierung valider Tiermodelle notwendig, um die grundlegenden Mechanismen gestörten Schlafs bei der Insomnie besser zu verstehen. Hinsichtlich der pharmakologischen Therapie muss ein Innovationsstau, zumindest in Europa konstatiert werden. Die kognitiv-verhaltenstherapeutische Behandlung der Insomnien (KVT-I), die durch viele Evidenzen sowohl kurz- als auch langfristig wirksam ist, sollte als „First-line“-Behandlung akzeptiert werden. Leider besteht jedoch nur für eine Minderheit von Betroffenen aufgrund mangelnder Ressourcen eine gute Zugangsmöglichkeit zu dieser Behandlungsform. Sog. Stepped-care-Modelle schlagen zur Lösung dieses Versorgungsproblems Selbsthilfeprogramme, internetbasierte Ansätze, gemeindezentrierte Aktivitäten und erst zuletzt Fachärzte und Schlafspezialisten als Behandlungsoptionen vor.

Abstract

Current diagnostic concepts, i.e. ICD-10 or DSM IV, do not fully encompass the complexity and heterogeneity of insomnia disorders. Advances have been made with ICSD-2 and the Research Diagnostic Criteria (RDC). Further progress will be made with the DSM V, which will encompass a main diagnostic category of “insomnia disorder”. Concerning etiological and pathophysiological assumptions, the hyperarousal model has gained wide-spread attention. Nevertheless, many of its tenets have only been confirmed by single studies, so further clinical research will be necessary to fully support the model. Additionally, animal models of insomnia are needed to advance the understanding of basic mechanisms involved in insomnia. With respect to treatment, there is a lack of new developments in the field of hypnotics for Europe. Concerning cognitive behavioral therapy of insomnia (CBT-I), much empirical evidence underlines that this type of treatment should be the first line treatment for insomnia. Unfortunately, only a minority of patients seem to have access to the benefits of this treatment due to a lack of resources. Stepped-care models for insomnia suggest self-help programs, internet-based approaches, community-centered activities (specially trained nurses) and as a last resort medical specialists and sleep experts to treat insomnia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. AASM (American Academy of Sleep Medicine) (2005) International classification of sleep disorders, 2. Aufl. AASM, Westchester

  2. Ohayon M (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6:97–111

    Article  PubMed  Google Scholar 

  3. Mallon L, Broman JE, Hetta J (2002) Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Intern Med 251:207–216

    Article  PubMed  CAS  Google Scholar 

  4. Hayashino Y, Fukuhara S, Suzukamo Y et al (2007) Relation between sleep quality and quantity, quality of life, and risk of developing diabetes in healthy workers in Japan: the high risk and population strategy for occupational health promotion. BMC Public Health 7:129–137

    Article  PubMed  Google Scholar 

  5. Daley M, Morin CM, LeBlanc M et al (2009) The economic burden of insomnia: direct and indirect costs for individuals with insomnia syndrome, insomnia symptoms, and good sleepers. Sleep 32:55–64

    PubMed  Google Scholar 

  6. Benca RM, Obermeyer WH, Thistedt RA, Gillin JC (1992) Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry 49:651–668

    Article  PubMed  CAS  Google Scholar 

  7. Riemann D, Berger M, Voderholzer U (2001) Sleep in depression: results from psychobiological studies. Biol Psychol 57:67–103

    Article  PubMed  CAS  Google Scholar 

  8. Riemann D, Voderholzer U (2003) Primary insomnia: a risk factor to develop depression? J Affect Disord 76:255–259

    Article  PubMed  Google Scholar 

  9. Baglioni C, Battagliese G, Feige B et al (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 135:10–19

    Article  PubMed  Google Scholar 

  10. Harvey AG, Murray G, Chandler RA et al (2011) Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms. Clin Psychol Rev 31:225–235

    Article  PubMed  Google Scholar 

  11. Wulff K, Gatti S, Wettstein JG, Foster RG (2010) Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci 11:1–11

    Article  Google Scholar 

  12. Ford DE, Kamerow DB (1989) Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA 262:1479–1484

    Article  PubMed  CAS  Google Scholar 

  13. Perlis ML, Giles DE, Mendelson WB et al (1997) Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J Sleep Res 6:179–188

    Article  PubMed  CAS  Google Scholar 

  14. Riemann D, Spiegelhalder K, Feige B et al (2010) The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev 14:19–31

    Article  PubMed  Google Scholar 

  15. Ellis J, Gehrman P, Espie C et al (2012) Acute insomnia: current conceptualizations and future directions. Sleep Med Rev 16:5–14

    Article  PubMed  Google Scholar 

  16. Baglioni C, Spiegelhalder K, Nissen C, Riemann D (Im Druck) Future directions in insomnia diagnosis and treatment: In: Kushida C (Hrsg) Encyclopedia of sleep

  17. Riemann D, Spiegelhalder K, Espie CA et al (2011) Chronic insomnia: clinical and research challenges – an agenda. Pharmacopsychiatry 44:1–14

    Article  PubMed  CAS  Google Scholar 

  18. ICD-10: Internationale Klassifikation psychischer Störungen (1999; 3. Auflage) WHO; Hans Huber, Bern

  19. American Psychiatric Association (APA) (1994) Diagnostic and statistical manual of mental disorders, 4. Aufl. Washington

  20. Edinger JD, Bonnet MH, Bootzin RR et al (2004) Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep 27:1567–1596

    PubMed  Google Scholar 

  21. Riemann D (2007) Insomnia and comorbid psychiatric disorders. Sleep Med 4:S15–S20

    Article  Google Scholar 

  22. Lichstein KL (2006) Secondary insomnia: a myth dismissed. Sleep Med Rev 10:3–5

    Article  PubMed  Google Scholar 

  23. Riemann D (2009) Does effective management of sleep disorders reduce depressive symptoms and the risk of depression? Drugs 69:43–64

    Article  PubMed  CAS  Google Scholar 

  24. NIH (2005) National Institutes of Health State of the Science Conference Statement. Manifestations and management of chronic insomnia in adults. Sleep 28:1049–1057

    Google Scholar 

  25. Reynolds CF, Redline S (2010) DSM-V sleep-wake disorders workgroup and advisors. The DSM-V sleep-wake disorders nosology: an update and an invitation to the sleep community. Sleep 33:10–11

    PubMed  Google Scholar 

  26. Riemann D, Morin C, Reynolds CF (2011) Das Kapitel Schlafstörungen im DSM-V: ein Zwischenbericht. Z Psychiatrie Psychol Psychother 4:275–280

    Google Scholar 

  27. Morin CM, LeBlanc M, Daley M et al (2006) Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med 7:123–130

    Article  PubMed  CAS  Google Scholar 

  28. Koffel E, Watson D (2009) The two-factor structure of sleep complaints and its relation to depression and anxiety. J Abnorm Psychol 118:183–194

    Article  PubMed  Google Scholar 

  29. Riemann D, Hajak G (2009) Insomnien: I. Ätiologie, Pathophysiologie und Diagnostik. Nervenarzt 9:1060–1069

    Article  Google Scholar 

  30. Mayer G, Fietze I, Fischer J et al (2009) S3-Leitlinie Nicht-erholsamer Schlaf/Schlafstörungen. Somnologie 13(Suppl 1):1–160

    Google Scholar 

  31. Buysse DJ, Ancoli-Israel S, Edinger JD et al (2006) Recommendations for a standard research assessment of insomnia. Sleep 29:1155–1173

    PubMed  Google Scholar 

  32. Carney CE, Buysse DJ, Ancoli-Israel S et al (2012) The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep 35:287–302

    PubMed  Google Scholar 

  33. Riemann D (2012) Insomnia research is coming of age. Sleep 35:175

    PubMed  Google Scholar 

  34. Feige B, Al-Shajlawi A, Nissen C et al (2008) Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients. J Sleep Res 17:180–190

    Article  PubMed  Google Scholar 

  35. Vgontzas A, Fernandez-Mendoza J, Bixler EO et al (2012) Persistent insomnia: the role of objective short sleep duration and mental health. Sleep 35:61–68

    PubMed  Google Scholar 

  36. Fernandez-Mendoza J, Vgontzas AN, Liao D et al (Im Druck) Insomnia with objective short sleep duration and incident hypertension: the Penn state cohort. Hypertension

  37. Bonnet M, Arand DL (2010) Hyperarousal and insomnia: state of the science. Sleep Med Rev 14:9–15

    Article  PubMed  Google Scholar 

  38. Nofzinger EA, Buysse DJ, Germain A et al (2004) Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry 161:2126–2129

    Article  PubMed  Google Scholar 

  39. Riemann D, Voderholzer U, Spiegelhalder K et al (2007) Chronic insomnia and MRI-measured hippocampal volumes: A pilot study. Sleep 30:955–958

    PubMed  Google Scholar 

  40. Winkelman JW, Benson KL, Buxton OM et al (2010) Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med 11:576–582

    Article  PubMed  Google Scholar 

  41. Altena E, Van der Werf Y, Sanz-Arigita EJ et al (2008) Prefrontal hypoactivation and recovery in insomnia. Sleep 31:1271–1276

    PubMed  Google Scholar 

  42. Riemann D, Spiegelhalder K, Nissen C et al (2012) REM sleep instability – a new pathway for insomnia? Pharmacopsychiatry 45:167–176

    PubMed  CAS  Google Scholar 

  43. Cano G, Mochizuki T, Saper CB (2008) Neural circuitry of stress-induced insomnia in rats. J Neurosci 28:10167–10184

    Article  PubMed  CAS  Google Scholar 

  44. Revel FG, Gottwowik J, Gatti S et al (2009) Rodent models of insomnia: a review of experimental procedures that induce sleep disturbances. Neurosci Biobehav Rev 33:874–899

    Article  PubMed  Google Scholar 

  45. Riemann D, Baglioni C, Spiegelhalder K (2011) Schlafmangel und Insomnie – Auswirkungen auf die körperliche und psychische Gesundheit. Bundesgesundheitsblatt 54:1296–1302

    Article  CAS  Google Scholar 

  46. Riemann D, Nissen C (2012) Sleep and psychotropic drugs In: Espie CA, Morin CM (Hrsg) Oxford handbook of sleep and sleep disorders. Oxford Press, Oxford, S 190–222

  47. Riemann D, Perlis ML (2009) The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies. Sleep Med Rev 13:205–214

    Article  PubMed  Google Scholar 

  48. Sullivan S (2012) Update on emerging drugs for insomnia. Drugs 17:295–298

    CAS  Google Scholar 

  49. Espie CA (2009) „Stepped care“: a health technology solution for delivering cognitive behavioral therapy as a first line insomnia treatment. Sleep 32:1549–1558

    PubMed  Google Scholar 

  50. Ritterband LM, Thorndike FP, Gonder-Frederick LA et al (2009) Efficacy of an internet-based behavioral intervention for adults with insomnia. Arch Gen Psychiatry 66:692–698

    Article  PubMed  Google Scholar 

  51. Espie C, Kyle SD, Williams C et al (2012) A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automatized media-rich web application. Sleep 35:769–781

    PubMed  Google Scholar 

  52. Manber R, Edinger JD, Gress JL et al (2008) Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia. Sleep 31:489–495

    PubMed  Google Scholar 

  53. Smith MT, Huang MI, Manber R (2005) Cognitive behaviour therapy for chronic insomnia occurring within the context of medical and psychiatric disorders. Clin Psychol Rev 25:559–592

    Article  PubMed  Google Scholar 

  54. Baglioni C, Spiegelhalder K, Lombardo C et al (2010) Sleep and emotions: a focus on insomnia. Sleep Med Rev 14:227–238

    Article  PubMed  Google Scholar 

  55. Azevedo MH, Bos SC, Soares MJ et al (2010) Longitudinal study on perfectionism and sleep disturbances. World J Biol Psychiatry 11:476–485

    Article  PubMed  Google Scholar 

  56. Schlarb A (2011) Kiss – Therapeutenmanual: Das Training für Kinder von 5 bis 10 Jahren mit Schlafsörungen. Kohlhammer, Stuttgart

  57. Harris J, Lack L, Wright H et al (2007) Intensive sleep retraining treatment for chronic primary insomnia: a preliminary investigation. J Sleep Res 16:276–284

    Article  PubMed  Google Scholar 

  58. Harris J, Lack L, Kemp K et al (2012) A ransdomized controlled trial of intensive sleep retraining (ISR): a brief conditioning treatment for chronic insomnia. Sleep 35:49–60

    PubMed  Google Scholar 

  59. Ludwig DS, Kabat-Zinn J (2008) Mindfulness in medicine. JAMA 300:1350–1352

    Article  PubMed  CAS  Google Scholar 

  60. Forman EM, Chapman JE, Herbert DJ et al (2012) Using session-by- session measurement to compare mechanisms of action for acceptance and committment therapy and cognitive therapy. Behav Ther 43:341–354

    Article  PubMed  Google Scholar 

  61. Baglioni C, Riemann D (2012) Is chronic insomnia a precursor to major depression? Epidemiological and biological findings? Curr Psychiat Rep 14:511–518

    Article  Google Scholar 

  62. Spiegelhalder K, Backhaus J, Riemann D (2011) Schlafstörungen – Fortschritte der Psychotherapie. Hogrefe, Göttingen

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to D. Riemann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baglioni, C., Spiegelhalder, K., Nissen, C. et al. Insomnische Störungen. Somnologie 17, 6–14 (2013). https://doi.org/10.1007/s11818-013-0602-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11818-013-0602-4

Schlüsselwörter

Keywords

Navigation