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Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis

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Abstract

Introduction: The aim of our study was toevaluate tumor angiogenesis as a prognosticmarker of transitional cell carcinoma of thebladder and to asses its relationship toestablished variables for survival and responseto therapy.Patients and method: Microvessel density(MVD), a measure of tumor angiogenesis, wereevaluated in 77 primary bladder cancers.Forty-three superficial carcinomas and 34invasive carcinomas were analysed. Tumorspecimens of all patients were obtained bytransurethral resection (TUR) and all thetumors were transitional cell carcinomas.Twenty-two patients with invasive bladdercancer have undergone M-VEC chemotheraphy. Thecorrelation between MVD and histopathologicalgrade, tumor stage and prognosis was evaluated.MVD was identified by immunostaining ofendothelial cells using anti-CD34 antibody. Forstatistical analysis Kruskal-Vallis,Mann-Whitney U and Fisher’s exact tests were used.Results: MVD was correlated with tumorgrade, stage and prognosis. Significantlyhigher MVD was determined in invasive tumorsthan superficial tumors (p < 0.05). MVDincreased with tumor grade and stage(p < 0.05). High MVD was correlated with therisk of clinical progression in bothsuperficial and invasive bladder carcinomas(p < 0.05, p < 0.001 respectively). Invasivetumors with remission after M-VEC chemotheraphyhad lower MVD than tumors with progressionafter M-VEC.Conclusion: These data demonstrate thatMVD in bladder carcinoma correlates with grade,stage and malignant potential of the tumor.Quantification of tumor angiogenesis may allowselection of the type of treatment for bladdercancer patients.

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References

  1. Rozanski TA, Grossman HB. Recent developments in the pathophysiology of bladder cancer. Am J Roentgenol 1994; 163: 789–792.

    Google Scholar 

  2. Fair WR, Fuks ZY, Scher HI. Cancer of the Bladder. Principles and Practice of Oncology, 4th edn. Philadelphia: Lippincott, 1993: 1052–1072.

    Google Scholar 

  3. Lutzeyer W, Rubben H, Dahm H. Prognostic parameters in superficial bladder cancer: an analysis of 315 patients. J Urol 1982; 127: 250–252.

    Google Scholar 

  4. Frazier HA, Robertson JE, Dodge RK, Paulson DF. The value of pathologic factors in predicting cancer-specific survival among patients treated with radical cystectomy for transitional cell carcinoma of the bladder and prostate. Cancer 1993; 71: 3993–4001.

    Google Scholar 

  5. Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol 1995; 13: 765–782.

    Google Scholar 

  6. Macchiarini P, Fontanini G, Hardin MJ et al. Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet 1992; 340: 145–146.

    Article  CAS  PubMed  Google Scholar 

  7. Pavlopoulos PM, Konstantinidou AE, Agapitos E et al. A morphometric study of neovascularization in colorectal carcinoma. Cancer 1998; 83: 2067–2075.

    Article  CAS  PubMed  Google Scholar 

  8. Weidner N. Intratumoral vascularity as a prognostic factor in cancers of the urogenital tract. Eur J Cancer 1996; 32A: 2506–2512.

    Google Scholar 

  9. Epstein JI, Amin MB, Reuter VR, Mostofi FK. The World Health Organisation/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Am J Surg Pathol 1998; 22: 1435–1448.

    Article  CAS  PubMed  Google Scholar 

  10. Abel PD. Prognostic indices in transitional cell carcinoma of the bladder. Br J Urol 1988; 62: 103–109.

    Google Scholar 

  11. Eure GR, Cundiff MR, Schellhammer PF. Bacillus-calmette-Guerin therapy for high risk stage T1 superficial bladder cancer. J Urol 1992; 147: 376–379.

    Google Scholar 

  12. Herr HW, Laudone VP, Badalament RA et al. Bacillus-Calmette-Guerin therapy alters the progression of superficial bladder cancer. J Clin Oncol 1988; 6: 1450–1455.

    Google Scholar 

  13. Sternberg CN. Adjuvant and neo-adjuvant chemotherapy of invasive bladder cancer. EAU Update Series 1995; 4(4): 26–34.

    Google Scholar 

  14. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Nat Cancer Inst 1990; 82: 4–6.

    Google Scholar 

  15. Dickinson AJ, Fox SB, Persad RA et al. Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas. Br J Urol 1994; 74: 762–766.

    CAS  PubMed  Google Scholar 

  16. Jaeger TM, Weidner N, Chew K et al. Tumor angiogenesis correlates with lymph node metastasis in invasive bladder cancer. J Urol 1995; 154: 69–71.

    CAS  PubMed  Google Scholar 

  17. Chaudhary R, Bromley M, Clarke NW et al. Prognostic relevance of microvessel density in cancer of the urinary bladder. Anticancer Res 1999; 19: 3479–3484.

    Google Scholar 

  18. Inoue K, Slaton JW, Karashima T et al. The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy. Clin Cancer Res 2000; 6: 4866–4873.

    Google Scholar 

  19. Bochner BH, Esrig D, Groshen S et al. relationship of tumor angiogenesis and nuclear p53 accumulation in invasive bladder cancer. Clin Cancer Res 1997; 3: 1615–1622.

    Google Scholar 

  20. Philp EA, Stephenson TJ, Reed MWR. Prognostic significance of angiogenesis in transitional cell carcinoma of the human urinary bladder. Br J Urol 1996; 77: 352–357.

    Google Scholar 

  21. Hawke CK, Delahunt B, Davidson PJT. Microvessel density as a prognostic marker for transitional cell carcinoma of the bladder. Br J Urol 1998; 81: 585–590.

    Google Scholar 

  22. Korkolopoulou P, Konstantinidou AE, Kavantzas N et al. Morphometric microvascular characteristics predict prognosis in superficial and invasive bladder cancer. Virc Arch 2001; 438: 603–611.

    Google Scholar 

  23. Dinney CPN, Babkowski RC, Antelo M et al. Relationship among cystectomy, microvessel density and prognosis in stage T1 transitional cell carcinoma of the bladder. J Urol 1998; 160: 1285–1290.

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology,School of Medicine, University of Ankara, Ankara, Turkey

    Ali Canoğlu, Çağatay Göğüş, Yaşar Bedük, Diclehan Orhan, Özden Tulunay & Sümer Baltacı

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  1. Ali Canoğlu
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  2. Çağatay Göğüş
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  3. Yaşar Bedük
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  4. Diclehan Orhan
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  5. Özden Tulunay
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  6. Sümer Baltacı
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Correspondence to Çağatay Göğüş.

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Canoğlu, A., Göğüş, Ç., Bedük, Y. et al. Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis. Int Urol Nephrol 36, 401–405 (2004). https://doi.org/10.1007/s11255-004-8869-9

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  • DOI: https://doi.org/10.1007/s11255-004-8869-9

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