Skip to main content
Log in

Boundary Lubrication in Natural Articular Joints

  • Review Paper
  • Published:
Tribology Letters Aims and scope Submit manuscript

Abstract

This review concentrates on studies into the behaviour of natural articular cartilage under boundary lubrication. This includes investigations into the chemical composition at the surface of cartilage, carried out as a means of identifying the boundary lubricant. Studies on the friction of cartilage sliding against cartilage and cartilage sliding steel or glass under conditions expected to be in the boundary regime are described. Additionally, model studies on the possible mechanisms of boundary lubrication using well-defined artificial surfaces are also discussed. Although there appears to be some contradiction between the results of friction measurements, an explanation can, at least in part, be given in terms of the layer of cartilage that is being measured. The different chemical nature and lubricating behaviour of the layers found at or near the surface are discussed in relation to the various results given in the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Dowson, D., Jin, Z.-M.: Micro-elastohydrodynamic lubrication of synovial joints. Eng. Med. 15(2), 63–65 (1986). doi:10.1243/EMED_JOUR_1986_015_019_02

    Article  PubMed  CAS  Google Scholar 

  2. Murakami, T.: The Lubrication in Natural Synovial Joints and Joint Prostheses. JSME Int. J. Ser. III Vibrat. Control Eng. Eng. Ind. 33(4), 465–474 (1990)

    Google Scholar 

  3. Jin, Z.M., Dowson, D.: Elastohydrodynamic Lubrication in Biological Systems. Proc. Inst. Mech. Eng. J. J. Eng. Tribol. 219(J5), 367–380 (2005). doi:10.1243/135065005X33982

    Article  Google Scholar 

  4. Murakami, T., Higaki, H., Sawae, Y., Ohtsuki, N., Moriyama, S., Nakanishi, Y.: Adaptive multimode lubrication in natural synovial joints and artificial joints. Proc. Inst. Mech. Eng. H J. Eng. Med. 212(H1), 23–35 (1998). doi:10.1243/0954411981533791

    Article  CAS  Google Scholar 

  5. Graindorge, S., Ferrandez, W., Jin, Z.M., Ingham, E., Fisher, J.: The natural synovial joint: a finite element investigation of biphasic surface amorphous layer lubrication under dynamic loading conditions. Proc. Inst. Mech. Eng. J. J. Eng. Tribol. 220(J8), 671–681 (2006). doi:10.1243/13506501JET95

    Article  Google Scholar 

  6. Ateshian, G.A., Hung, C.T.: The natural synovial joint: properties of cartilage. Proc. Inst. Mech. Eng. J. J. Eng. Tribol. 220(J8), 657–670 (2006). doi:10.1243/13506501JET86

    Article  Google Scholar 

  7. Neville, A., Morina, A., Liskiewicz, T., Yan, Y.: Synovial joint lubrication—does nature teach more effective engineering lubrication strategies? Proc. Inst. Mech. Eng. C J. Eng. Mech. Eng. Sci. 221(10), 1223–1230 (2007)

    Google Scholar 

  8. Dumbleton, J.H.: Tribology of Natural and Artificial Joints. Elsevier, Amsterdam (1981)

    Google Scholar 

  9. Oconnor, P., Orford, C.R., Gardner, D.L.: Role of proteoglycan and collagen in the mechanical-behavior of articular-cartilage. Br. J. Rheumatol. 24(2), 200 (1985)

    Google Scholar 

  10. Hills, B.A.: Boundary lubrication in vivo. Proc. Inst. Mech. Eng. H J. Eng. Med. 214(H1), 83–94 (2000). doi:10.1243/0954411001535264

    Article  CAS  Google Scholar 

  11. Crockett, R., Roos, S., Rossbach, P., Dora, C., Born, W., Troxler, H.: Imaging of the surface of human and bovine articular cartilage with ESEM and AFM. Tribol. Lett. 19(4), 311–317 (2005). doi:10.1007/s11249-005-7448-2

    Article  CAS  Google Scholar 

  12. Maniwa, S., Nishikori, T., Furukawa, S., Kajitani, K., Ochi, M.: Alteration of collagen network and negative charge of articular cartilage surface in the early stage of experimental osteoarthritis. Arch. Orthop. Trauma Surg. 121(4), 181–185 (2001). doi:10.1007/s004020000203

    Article  PubMed  CAS  Google Scholar 

  13. Kawai, N., Tanaka, E., Takata, T., Miyauchi, M., Tanaka, M., Todoh, M., van Eijden, T., Tanne, K.: Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint. J. Biomed. Mater. Res. A 70A(1), 149–153 (2004). doi:10.1002/jbm.a.30078

    Article  CAS  Google Scholar 

  14. Graindorge, S., Ferrandez, W., Ingham, E., Jin, Z., Twigg, P., Fisher, J.: The role of the surface amorphous layer of articular cartilage in joint lubrication. Proc. Inst. Mech. Eng. H J. Eng. Med. 220(H5), 597–607 (2006). doi:10.1243/09544119JEIM122

    Article  CAS  Google Scholar 

  15. Kirk, T.B., Wilson, A.S., Stachowiak, G.W.: The effects of dehydration on the surface-morphology of articular-cartilage. J. Orthop. Rheumatol. 6(2–3), 75–80 (1993)

    Google Scholar 

  16. Kirk, T.B., Wilson, A.S., Stachowiak, G.W.: The morphology and composition of the superficial zone of mammalian articular-cartilage. J. Orthop. Rheumatol. 6(1), 21–28 (1993)

    Google Scholar 

  17. Bloebaum, R.D., Wilson, A.S.: The structure of the surface of articular-cartilage. J. Anat. 132(Mar), 295 (1981)

    Google Scholar 

  18. Bloebaum, R.D., Wilson, A.S.: The morphology of the surface of articular-cartilage in adult-rats. J. Anat. 131(Sep), 333–346 (1980)

    PubMed  CAS  Google Scholar 

  19. Kumar, P., Oka, M., Toguchida, J., Kobayashi, M., Uchida, E., Nakamura, T., Tanaka, K.: Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints. J. Anat. 199, 241–250 (2001). doi:10.1046/j.1469-7580.2001.19930241.x

    Article  PubMed  CAS  Google Scholar 

  20. Jurvelin, J.S., Muller, D.J., Wong, M., Studer, D., Engel, A., Hunziker, E.B.: Surface and subsurface morphology of bovine humeral articular cartilage as assessed by atomic force and transmission electron microscopy. J. Struct. Biol. 117(1), 45–54 (1996). doi:10.1006/jsbi.1996.0068

    Article  PubMed  CAS  Google Scholar 

  21. Sawae, Y., Murakami, T., Matsumoto, K., Horimoto, M.: Study on morphology and lubrication of articular cartilage surface with atomic force microscopy. J. Jpn. Soc. Tribol. 45(2), 150–157 (2000)

    Google Scholar 

  22. Orford, C.R., Gardner, D.L.: Ultrastructural histochemistry of the surface lamina of normal articular-cartilage. Histochem. J. 17(2), 223–233 (1985). doi:10.1007/BF01003221

    Article  PubMed  CAS  Google Scholar 

  23. Hills, B.A., Crawford, R.W.: Normal and prosthetic synovial joints are lubricated by surface-active phospholipid—a hypothesis. J. Arthroplasty 18(4), 499–505 (2003). doi:10.1016/S0883-5403(03)00072-X

    Article  PubMed  CAS  Google Scholar 

  24. Hills, B.A., Monds, M.K.: Enzymatic identification of the load-bearing boundary lubricant in the joint. Br. J. Rheumatol. 37(2), 137–142 (1998). doi:10.1093/rheumatology/37.2.143

    Article  PubMed  CAS  Google Scholar 

  25. Sarma, A.V., Powell, G.L., LaBerge, M.: Phospholipid composition of articular cartilage boundary lubricant. J. Orthop. Res. 19(4), 671–676 (2001). doi:10.1016/S0736-0266(00)00064-4

    Article  PubMed  CAS  Google Scholar 

  26. Ogston, A.G., Stanier, J.E.: On the state of hyaluronic acid in synovial fluid. Biochem. J. 46(3), 364–376 (1950)

    PubMed  CAS  Google Scholar 

  27. Ogston, A.G., Stanier, J.E.: The dimensions of the particle of hyaluronic acid complex in synovial fluid. Biochem. J. 49(5), 585–590 (1951)

    PubMed  CAS  Google Scholar 

  28. Ogston, A.G., Stanier, J.E.: The physiological function of hyaluronic acid in synovial fluid—viscous, elastic and lubricant properties. J. Physiol. 119(2–3), 244–252 (1953)

    PubMed  CAS  Google Scholar 

  29. Crockett, R., Grubelnik, A., Roos, S., Dora, C., Born, W., Troxler, H.: Biochemical composition of the superficial layer of articular cartilage. J. Biomed. Mater. Res. A 82A(4), 958–964 (2007). doi:10.1002/jbm.a.31248

    Article  CAS  Google Scholar 

  30. Crescenzi, V., Taglienti, A., Pasquali-Ronchetti, I.: Supramolecular structures prevailing in aqueous hyaluronic acid and phospholipid vesicles mixtures: an electron microscopy and rheometric study. Colloids Surf. A Physicochem. Eng. Asp. 245(1–3), 133–135 (2004). doi:10.1016/j.colsurfa.2004.06.030

    Article  CAS  Google Scholar 

  31. Jay, G.D., Lane, B.P., Sokoloff, L.: Characterization of a bovine synovial-fluid lubricating factor. 3. The Interaction with hyaluronic-acid. Connect. Tissue Res. 28(4), 245–255 (1992). doi:10.3109/03008209209016818

    Article  PubMed  CAS  Google Scholar 

  32. Swann, D.A., Silver, F.H., Slayter, H.S., Stafford, W., Shore, E.: The molecular-structure and lubricating activity of lubricin isolated from bovine and human synovial-fluids. Biochem. J. 225(1), 195–201 (1985)

    PubMed  CAS  Google Scholar 

  33. Jay, G.D., Tantravahi, U., Britt, D.E., Barrach, H.J., Cha, C.J.: Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J. Orthop. Res. 19(4), 677–687 (2001). doi:10.1016/S0736-0266(00)00040-1

    Article  PubMed  CAS  Google Scholar 

  34. Jay, G.D., Britt, D.E., Cha, C.J.: Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J. Rheumatol. 27(3), 594–600 (2000)

    PubMed  CAS  Google Scholar 

  35. Swann, D.A., Hendren, R.B., Radin, E.L., Sotman, S.L., Duda, E.A.: The lubricating activity of synovial-fluid glycoproteins. Arthritis Rheum. 24(1), 22–30 (1981). doi:10.1002/art.1780240104

    Article  PubMed  CAS  Google Scholar 

  36. Jay, G.D., Harris, D.A., Cha, C.J.: Boundary lubrication by lubricin is mediated by O-linked beta(1–3)Gal-GalNAc oligosaccharides. Glycoconj. J. 18(10), 807–815 (2001). doi:10.1023/A:1021159619373

    Article  PubMed  CAS  Google Scholar 

  37. Jay, G.D., Torres, J.R., Rhee, D.K., Helminen, H.J., Hytinnen, M.M., Cha, C.J., Elsaid, K., Kim, K.S., Cui, Y.J., Warman, M.L.: Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum. 56(11), 3662–3669 (2007). doi:10.1002/art.22974

    Article  PubMed  CAS  Google Scholar 

  38. Jones, A.R.C., Gleghorn, J.P., Hughes, C.E., Fitz, L.J., Zollner, R., Wainwright, S.D., Caterson, B., Morris, E.A., Bonassar, L.J., Flannery, C.R.: Binding and localization of recombinant lubricin to articular cartilage surfaces. J. Orthop. Res. 25(3), 283–292 (2007). doi:10.1002/jor.20325

    Article  PubMed  CAS  Google Scholar 

  39. Nugent-Derfus, G.E., Chan, A.H., Schumacher, B.L., Sah, R.L.: PRG4 exchange between the articular cartilage surface and synovial fluid. J. Orthop. Res. 25(10), 1269–1276 (2007). doi:10.1002/jor.20431

    Article  PubMed  CAS  Google Scholar 

  40. Zappone, B., Greene, G.W., Oroudjev, E., Jay, G.D., Israelachvili, J.N.: Molecular aspects of boundary lubrication by human lubricin: Effect of disulfide bonds and enzymatic digestion. Langmuir 24(4), 1495–1508 (2008). doi:10.1021/la702383n

    Article  PubMed  CAS  Google Scholar 

  41. Schaefer, D.B., Wendt, D., Moretti, M., Jakob, M., Jay, G.D., Heberer, M., Martin, I.: Lubricin reduces cartilage–cartilage integration. Biorheology 41(3–4), 503–508 (2004)

    PubMed  CAS  Google Scholar 

  42. Englert, C., McGowan, K.B., Klein, T.J., Giurea, A., Schumacher, B.L., Sah, R.L.: Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum. 52(4), 1091–1099 (2005). doi:10.1002/art.20986

    Article  PubMed  CAS  Google Scholar 

  43. Jay, G.D., Torres, J.R., Warman, M.L., Laderer, M.C., Breuer, K.S.: The role of lubricin in the mechanical behavior of synovial fluid. Proc. Natl. Acad. Sci. USA 104(15), 6194–6199 (2007). doi:10.1073/pnas.0608558104

    Article  PubMed  ADS  CAS  Google Scholar 

  44. Mabuchi, K., Tsukamoto, Y., Obara, T., Yamaguchi, T.: The effect of additive hyaluronic-acid on animal joints with experimentally reduced lubricating ability. J. Biomed. Mater. Res. 28(8), 865–870 (1994). doi:10.1002/jbm.820280805

    Article  PubMed  CAS  Google Scholar 

  45. Obara, T., Mabuchi, K., Iso, T., Yamaguchi, T.: Increased friction of animal joints by experimental degeneration and recovery by addition of hyaluronic acid. Clin. Biomech. (Bristol, Avon) 12(4), 246–252 (1997). doi:10.1016/S0268-0033(97)00004-1

    Article  Google Scholar 

  46. Schmidt, T.A., Sah, R.L.: Effect of synovial fluid on boundary lubrication of articular cartilage. Osteoarthr. Cartil. 15(1), 35–47 (2007). doi:10.1016/j.joca.2006.06.005

    Article  PubMed  CAS  Google Scholar 

  47. Schmidt, T.A., Gastelum, N.S., Nguyen, Q.T., Schumacher, B.L., Sah, R.L.: Boundary lubrication of articular cartilage—role of synovial fluid constituents. Arthritis Rheum. 56(3), 882–891 (2007). doi:10.1002/art.22446

    Article  PubMed  CAS  Google Scholar 

  48. Kawano, T., Miura, H., Mawatari, T., Moro-Oka, T., Nakanishi, Y., Higaki, H., Iwamoto, Y.: Mechanical effects of the intraarticular administration of high molecular weight phospholipid on synovial joint articular cartilage degeneration hyaluronic acid plus lubrication and prevention of in experimental osteoarthritis. Arthritis Rheum. 48(7), 1923–1929 (2003). doi:10.1002/art.11172

    Article  PubMed  CAS  Google Scholar 

  49. Mabuchi, K., Obara, T., Ikegami, K., Yamaguchi, T., Kanayama, T.: Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration. Clin. Biomech. (Bristol, Avon) 14(5), 352–356 (1999). doi:10.1016/S0268-0033(98)00084-9

    Article  CAS  Google Scholar 

  50. Forster, H., Fisher, J.: The influence of continuous sliding and subsequent surface wear on the friction of articular cartilage. Proc. Inst. Mech. Eng. H J. Eng. Med. 213(H4), 329–345 (1999). doi:10.1243/0954411991535167

    Article  CAS  Google Scholar 

  51. Gleghorn, J.P., Bonassar, L.J.: Lubrication mode analysis of articular cartilage using Stribeck surfaces. J. Biomech. 41(9), 1910–1918 (2008). doi:10.1016/j.jbiomech.2008.03.043

    Article  PubMed  Google Scholar 

  52. Krishnan, R., Caligaris, M., Mauck, R.L., Hung, C.T., Costa, K.D., Ateshian, G.A.: Removal of the superficial zone of bovine articular cartilage does not increase its frictional coefficient. Osteoarthritis Cartilage 12(12), 947–955 (2004). doi:10.1016/j.joca.2004.08.009

    Article  PubMed  CAS  Google Scholar 

  53. Naka, M.H., Hattori, K., Ikeuchi, K.: Evaluation of the superficial characteristics of articular cartilage using evanescent waves in the friction tests with intermittent sliding and loading. J. Biomech. 39(12), 2164–2170 (2006). doi:10.1016/j.jbiomech.2005.06.015

    Article  PubMed  Google Scholar 

  54. Naka, M.H., Hattori, K., Ohashi, T., Ikeuchi, K.: Evaluation of the effect of collagen network degradation on the frictional characteristics of articular cartilage using a simultaneous analysis of the contact condition. Clin. Biomech. (Bristol, Avon) 20(10), 1111–1118 (2005). doi:10.1016/j.clinbiomech.2005.06.009

    Article  Google Scholar 

  55. Naka, M.H., Morita, Y., Ikeuchi, K.: Influence of proteoglycan contents and of tissue hydration on the frictional characteristics of articular cartilage. Proc. Inst. Mech. Eng. H J. Eng. Med. 219(H3), 175–182 (2005). doi:10.1243/095441105X34220

    Article  CAS  Google Scholar 

  56. Ozturk, H.E., Stoffel, K.K., Jones, C.F., Stachowiak, G.W.: The effect of surface-active phospholipids on the lubrication of osteoarthritic sheep knee joints. Friction. Tribol. Lett. 16(4), 283–289 (2004). doi:10.1023/B:TRIL.0000015204.41674.d3

    Article  CAS  Google Scholar 

  57. Klein, J.: Molecular mechanisms of synovial joint lubrication. Proc. Inst. Mech. Eng. J J. Eng. Tribol. 220(J8), 691–710 (2006). doi:10.1243/13506501JET143

    Article  CAS  Google Scholar 

  58. Zappone, B., Ruths, M., Greene, G.W., Jay, G.D., Israelachvili, J.N.: Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein. Biophys. J. 92(5), 1693–1708 (2007). doi:10.1529/biophysj.106.088799

    Article  PubMed  ADS  CAS  Google Scholar 

  59. Tadmor, R., Chen, N.H., Israelachvili, J.: Normal and shear forces between mica and model membrane surfaces with adsorbed hyaluronan. Macromolecules 36(25), 9519–9526 (2003). doi:10.1021/ma030379k

    Article  ADS  CAS  Google Scholar 

  60. Tadmor, R., Chen, N.H., Ismelachvili, J.N.: Normal AND shear forces BETWEEN MODEL MEMBRANE SURFACES WITH weakly adsorbed hyaluronan. In: 47th Annual Meeting of the Biophysical Society, 2003 Mar 01–05, San Antonio, Texas, 2003. p. 510A–A

  61. Tadmor, R., Chen, N.H., Israelachvili, J.N.: Thin film rheology and lubricity of hyaluronic acid solutions at a normal physiological concentration. J. Biomed. Mater. Res. 61(4), 514–523 (2002). doi:10.1002/jbm.10215

    Article  PubMed  Google Scholar 

  62. Tadmor, R., Chen, N.H., Israelachvili, J.N.: Thin film rheology and lubricity of hyaluronan solutions. Biophys. J. 82(1), 799 (2002)

    Google Scholar 

  63. Chang, D.P., Abu-Lail, N.I., Guilak, F., Jay, G.D., Zauscher, S.: Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir 24(4), 1183–1193 (2008). doi:10.1021/la702366t

    Article  PubMed  CAS  Google Scholar 

  64. Elsaid, K.A., Jay, G.D., Warman, M.L., Rhee, D.K., Chichester, C.O.: Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum. 52(6), 1746–1755 (2005). doi:10.1002/art.21038

    Article  PubMed  CAS  Google Scholar 

  65. Jay, G.D., Cha, C.J.: The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid. J. Rheumatol. 26(11), 2454–2457 (1999)

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rowena Crockett.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crockett, R. Boundary Lubrication in Natural Articular Joints. Tribol Lett 35, 77–84 (2009). https://doi.org/10.1007/s11249-009-9430-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11249-009-9430-x

Keywords

Navigation