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Schizophyllum commune: A New Organism in Eye Infection

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Abstract

Purpose

We report a case of mycotic keratitis caused by a rare fungus Schizophyllum commune.

Methods

Clinical examination, slit-lamp examination, and microbiological evaluation of the corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techniques, polymerase chain reaction and speciation by DNA sequencing.

Results

Corneal scraping showed the presence of fungal filaments. The fungus was identified as S. commune based on DNA sequence analysis of the internal transcribed spacer region. The organism was susceptible to amphotericin B and voriconazole and demonstrated resistance to anidulafungin, itraconazole, and fluconazole. Therapeutic keratoplasty was performed but there was recurrence of the infection in the graft, which was controlled with topical voriconazole and intracameral amphotericin B. At the end of 3 months, the affected eye had developed phthisis bulbi.

Conclusion

The best of our knowledge, this is the first reported case of keratitis caused by the rare fungus S. commune. Management of these cases is difficult, and surgical procedures may be needed.

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Authors and Affiliations

  1. Ocular Microbiology Services, Priyamvada Birla Aravind Eye Hospital, 10, Loudon Street, Kolkata, 700017, West Bengal, India

    Suman Saha

  2. Cornea Services, Priyamvada Birla Aravind Eye Hospital, Kolkata, India

    Jayangshu Sengupta & Archana Khetan

  3. Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal, India

    Debdulal Banerjee

  4. Central Research Facilities, Indian Institute of Technology, Kharagpur, West Bengal, India

    Santi Mohan Mandal

Authors
  1. Suman Saha
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  2. Jayangshu Sengupta
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  3. Debdulal Banerjee
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  4. Archana Khetan
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  5. Santi Mohan Mandal
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Corresponding author

Correspondence to Suman Saha.

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Saha, S., Sengupta, J., Banerjee, D. et al. Schizophyllum commune: A New Organism in Eye Infection. Mycopathologia 175, 357–360 (2013). https://doi.org/10.1007/s11046-013-9625-4

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  • DOI: https://doi.org/10.1007/s11046-013-9625-4

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