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Osteoimmunology: Crosstalk Between the Immune and Bone Systems

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Abstract

Introduction

The interaction between the immune and skeletal systems has long been acknowledged, but investigation into rheumatoid arthritis (RA) as well as the various bone phenotypes found in immunocompromised gene-deficient mice has highlighted the importance of the dynamic interplay between the two systems. This has led to the recent emergence and subsequent rapid evolution of the field of osteoimmunology.

Bone Destruction with Arthritis as a RANKL Disease

In the bone destruction associated with RA, IL-17-producing helper T cells (TH17) play a major role by inducing receptor activator of nuclear factor-κB ligand (RANKL). RANKL stimulates osteoclastogenesis through nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which is well known as a crucial regulator of immunity.

New Players in Osteoimmunology

In addition to cellular interactions via cytokines, the immune and skeletal systems share various molecules, including transcription factors, signaling molecules, and membrane receptors.

Conclusion

The scope of osteoimmunology has grown to encompass a wide range of molecular and cellular interactions, the elucidation of which will provide a scientific basis for future therapeutic approaches to diseases of both the immune and skeletal systems.

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Acknowledgments

This work was supported in part by Grant-in-Aid for Yong Scientists (A) and Grant-in-Aid for Creative Scientific Research from the Japan Society for the Promotion of Science, Grants-in-Aid for Global Center of Excellence (GCOE) program and Genome Network Project from Ministry of Education, Culture, Sports, Science, and Technology of Japan. It was also supported by grants from the Japan Medical Association, the Ichiro Kanehara Foundation, Uehara Memorial Foundation, Nakatomi Foundation, Life Science Foundation of Japan, Nagao Memorial Foundation, Takeda Science Foundation, Kowa Life Science Foundation, Naito Foundation, Sumitomo Foundation, Suzuken Memorial Foundation, Kanae Foundation,Senri Life Science Foundation and Astellas Foundation for Research on Metabolic Disorders.

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  1. Department of Cell Signaling, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan

    Tomoki Nakashima & Hiroshi Takayanagi

  2. Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Tomoki Nakashima & Hiroshi Takayanagi

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  1. Tomoki Nakashima
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Correspondence to Hiroshi Takayanagi.

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Nakashima, T., Takayanagi, H. Osteoimmunology: Crosstalk Between the Immune and Bone Systems. J Clin Immunol 29, 555–567 (2009). https://doi.org/10.1007/s10875-009-9316-6

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