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The Association Between Systemic Sclerosis, Arginine and Asymmetric Dimethylarginine

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Abstract

Systemic sclerosis (SSc) is a kind of autoimmune disease characterized by inflammatory and endothelial dysfunction. Asymmetric dimethylarginine (ADMA), as an endogenous nitric oxide synthase inhibitor, can cause or contribute to the inflammatory syndrome and endothelial dysfunction. Recently, increased ADMA levels have been demonstrated in SSc, revealing that ADMA might play an important role for the associated manifestations of SSc. Besides, ADMA may play a significant role in the level of NO, which is produced by arginine. In the review, we discuss the role of arginine and ADMA in patients with SSc.

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Acknowledgments

This work was partly supported by grants from the Key Project of the Education Department of Anhui Province Natural Science Research (code: KJ2012A165, KJ2014A127) and Anhui Provincial Natural Science Foundation (code: 1308085MH169).

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Authors and Affiliations

  1. Medical Genetics Center, Anhui Medical College, Hefei, China

    Li Zhang & Ying-xin Wang

  2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81, Meishan Road, Hefei, Anhui, 230032, People’s Republic of China

    Ya-Nan Wan, Yu-Jie Wang, Jun-Wei Yan, Xiao-Lei Huang & Jing Wang

  3. West Anhui Health Vocational College, Lu’an, China

    Jiu-Hua Zhao

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  1. Li Zhang
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Correspondence to Jing Wang.

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Li Zhang and Ya-Nan Wan contributed equally to this work and acted as co-first authors.

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Zhang, L., Wan, YN., Zhao, JH. et al. The Association Between Systemic Sclerosis, Arginine and Asymmetric Dimethylarginine. Inflammation 38, 218–223 (2015). https://doi.org/10.1007/s10753-014-0025-9

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