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Trends in estimated kidney function: the FINRISK surveys

  • Renal Diseases
  • Published:
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Abstract

We evaluated the temporary trend in estimated glomerular filtration rate (eGFR) of subjects aged from 25 to 74 years between two cross-sectional population surveys in 2002 and in 2007. The mean eGFR across age-groups, the prevalences of eGFR categories, and the prevalence of chronic kidney disease (CKD) stage 3–5 defined by eGFR < 60 mL/min/1.73 m2 were defined in sex- and age-specific groups using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Study equation. The eGFR decreased from year 2002 to 2007 across the age-groups in both genders. The prevalence of CKD stage 3–5 (eGFR < 60 mL/min/1.73) increased in women from 1.8 to 3.1% (P = 0.017), but not in men. In the combined analysis of both genders, CKD stage 3–5 was markedly more common in 2007 compared to 2002, with odds ratio (OR) 1.59 (95% confidence interval (CI) 1.22–2.08) remaining significant after adjusting the model for age, gender, study area, hypertension, obesity, prior cardiovascular disease, and diabetes mellitus, and being at lowest when only age, gender and waist circumference were included in the model (OR 1.34; 95% CI 1.02–1.76). To conclude, the mean eGFR decreased significantly during 2002–2007 in both sexes, and CKD stage 3–5 increased in women. This trend was concurrent with increases in mean waist circumference and in the prevalence of diabetes mellitus.

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Abbreviations

BMI:

Body mass index

CVD:

Cardiovascular disease

CI:

Confidence interval

CKD:

Chronic kidney disease

CKD-EPI:

Chronic Kidney Disease Epidemiology Collaboration Study

eGFR:

Estimated glomerular filtration rate

GFR:

Glomerular filtration rate

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Conflicts of interest

None of the authors report any potential conflicts of interest.

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Authors and Affiliations

  1. Institute of Clinical Medicine/Internal Medicine, University of Eastern Finland, P.O.B. 1777, 70211, Kuopio, Finland

    Auni Juutilainen

  2. Department of Medicine, Kuopio University Hospital, Kuopio, Finland

    Auni Juutilainen

  3. Institute of Clinical Medicine/Internal Medicine, University of Oulu, Oulu, Finland

    Helena Kastarinen, Riitta Antikainen & Mika Kastarinen

  4. Finnish Medicines Agency, Kuopio, Finland

    Helena Kastarinen & Mika Kastarinen

  5. Oulu City Hospital, Oulu, Finland

    Riitta Antikainen

  6. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    Markku Peltonen, Veikko Salomaa, Jaakko Tuomilehto, Pekka Jousilahti, Jouko Sundvall & Tiina Laatikainen

  7. South Ostrobothnia Central Hospital, Seinäjoki, Finland

    Jaakko Tuomilehto

  8. Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain

    Jaakko Tuomilehto

  9. Centre for Vascular Prevention, Danube-University Krems, Krems, Austria

    Jaakko Tuomilehto

  10. Department of Public Health, University of Helsinki, Helsinki, Finland

    Jaakko Tuomilehto

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  1. Auni Juutilainen
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  2. Helena Kastarinen
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Correspondence to Auni Juutilainen.

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Juutilainen, A., Kastarinen, H., Antikainen, R. et al. Trends in estimated kidney function: the FINRISK surveys. Eur J Epidemiol 27, 305–313 (2012). https://doi.org/10.1007/s10654-012-9652-3

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  • DOI: https://doi.org/10.1007/s10654-012-9652-3

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