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A Possible Role of GLP-1 in the Pathophysiology of Early Dumping Syndrome

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Abstract

Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.

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Authors and Affiliations

  1. The Department of Surgery, Shiga University of Medical Science, Shiga, Japan

    Hiroshi Yamamoto PhD, MD, Tsuyoshi Mori MD, Hiroshi Tsuchihashi MD, Hiroya Akabori MD, Hiroyuki Naito PhD, MD & Tohru Tani PhD, MD

  2. Department of Surgery, Shiga University of Medical Science, Seta-tsukinowa-cho, Otsu, Shiga, Japan, 520-2192

    Hiroshi Yamamoto PhD, MD

Authors
  1. Hiroshi Yamamoto PhD, MD
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  2. Tsuyoshi Mori MD
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  3. Hiroshi Tsuchihashi MD
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  4. Hiroya Akabori MD
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  5. Hiroyuki Naito PhD, MD
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  6. Tohru Tani PhD, MD
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Correspondence to Hiroshi Yamamoto PhD, MD.

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Yamamoto, H., Mori, T., Tsuchihashi, H. et al. A Possible Role of GLP-1 in the Pathophysiology of Early Dumping Syndrome. Dig Dis Sci 50, 2263–2267 (2005). https://doi.org/10.1007/s10620-005-3046-2

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  • DOI: https://doi.org/10.1007/s10620-005-3046-2

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